Protein: UME1
Transcriptional regulatory protein UME1 (WD repeat-containing transcriptional modulator 3)

Gene: UME1
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: Q03010

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006334 - nucleosome assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739908

RPD3
Histone deacetylase RPD3

14

0

Small-scale

0.728

High

650011

SIN3
Transcriptional regulatory protein SIN3

12

0

Small-scale

0.723

High

1040446

RCO1
Transcriptional regulatory protein RCO1

9

0

Small-scale

0.720

High

1040454

CTI6
Histone deacetylase complex subunit CTI6

7

0

Small-scale

0.711

High

796754

RXT2
Transcriptional regulatory protein RXT2

7

0

Small-scale

0.709

High

726273

DEP1
Transcriptional regulatory protein DEP1

5

0

Small-scale

0.682

High

1040456

EAF3
Chromatin modification-related protein EAF3

5

0

Small-scale

0.682

High

799731

SAP30
Transcriptional regulatory protein SAP30

4

0

Small-scale

0.661

High

1040448

RXT3
Transcriptional regulatory protein RXT3

3

0

High-throughput

0.634

High

898944

PHO23
Transcriptional regulatory protein PHO23

3

0

Small-scale

0.628

High

963674

H3
Histone H3

3

0

Small-scale

0.619

High

758068

ASH1
Transcriptional regulatory protein ASH1

3

0

Small-scale

0.606

High

825605

SDS3
Transcriptional regulatory protein SDS3

2

0

High-throughput

0.585

High

752648

HSP78
Heat shock protein 78, mitochondrial

2

2

High-throughput

0.571

High

819603

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

825373

XBP1
Transcriptional repressor XBP1

2

0

Small-scale

0.547

High

1039016

IMA1
Importin subunit alpha

1

1

High-throughput

0.536

High

1040450

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.518

High

677050

GID7
GID complex subunit 7

1

0

High-throughput

0.513

High

1040441

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.513

High

602612

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

692425

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.480

High

815546

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.480

High

850963

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.480

High

1040442

SKY1
Serine/threonine-protein kinase SKY1

1

0

High-throughput

0.480

High

1040452

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.480

High

367801

ENO1
Enolase 1

1

0

High-throughput

0.479

High

707983

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

748019

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

1040440

UME1
Transcriptional regulatory protein UME1

1

3

Small-scale

0.479

High

1040443

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.479

High

1040447

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

1040449

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

1040455

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

1040459

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

149925

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

382301

H4
Histone H4

1

0

High-throughput

0.458

High

435312

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436134

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

514800

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

674799

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

680611

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

0

High-throughput

0.458

High

700069

FUN19
SWIRM domain-containing protein FUN19

1

0

High-throughput

0.458

High

734463

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.458

High

739740

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.458

High

741080

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

763983

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

792214

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

802351

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

808894

UME6
Transcriptional regulatory protein UME6

1

0

Small-scale

0.458

High

1033527

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1040444

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1040451

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1040458

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

524938

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

527508

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

546016

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

742250

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

849687

RGD2
Rho-GTPase-activating protein RGD2

1

0

High-throughput

0.438

High

381226

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

1040445

DHR1
Probable ATP-dependent RNA helicase DHR1

2

0

High-throughput

0.324

High

554444

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

0

High-throughput

0.282

High

1040457

OSH2
Oxysterol-binding protein homolog 2

1

0

High-throughput

0.282

High

405132

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

383863

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410307

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433817

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

442079

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

455232

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503208

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

513183

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

689629

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

753551

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

909761

YPT32
GTP-binding protein YPT32/YPT11

1

0

High-throughput

0.249

Low

1040453

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025