Protein: PELI3
E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27)

Gene: PELI3
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q8N2H9

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0008592 - regulation of Toll signaling pathway
GO:0010804 - negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0045087 - innate immune response
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

905619

IRAK1
Interleukin-1 receptor-associated kinase 1

8

10

Small-scale

0.744

High

1324353

TRAF6
TNF receptor-associated factor 6

5

3

Small-scale

0.718

High

213964

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

5

Small-scale

0.650

High

930990

HSP72
Heat shock-related 70 kDa protein 2

2

3

High-throughput

0.621

High

1324344

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

0

High-throughput

0.607

High

214449

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

Small-scale

0.578

High

537505

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.536

High

600861

HSP76
Heat shock 70 kDa protein 6

1

3

High-throughput

0.536

High

821445

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.536

High

1007136

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.536

High

1259343

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.536

High

1324343

TCPW
T-complex protein 1 subunit zeta-2

1

2

High-throughput

0.536

High

457552

TBB5
Tubulin beta chain

1

0

High-throughput

0.513

High

1110377

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

0

High-throughput

0.513

High

1231845

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.513

High

1324347

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.513

High

1324352

RUVB1
RuvB-like 1

1

0

High-throughput

0.513

High

957788

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

4

Small-scale

0.501

High

1103914

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

5

Small-scale

0.501

High

650559

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

0

High-throughput

0.493

High

1324346

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

0

Small-scale

0.493

High

832083

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

0

High-throughput

0.493

High

884771

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

1324345

TRI63
E3 ubiquitin-protein ligase TRIM63

1

1

High-throughput

0.481

High

1324348

TRI55
Tripartite motif-containing protein 55

1

1

High-throughput

0.481

High

422562

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

210197

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

11

Small-scale

0.479

High

891673

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.479

High

1324349

IRAK4
Interleukin-1 receptor-associated kinase 4

1

2

Small-scale

0.479

High

282605

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

3

High-throughput

0.470

High

1159133

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

0

Small-scale

0.458

High

1324350

DNJB4
DnaJ homolog subfamily B member 4

1

0

High-throughput

0.458

High

1324351

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.458

High

516201

HS71B
Heat shock 70 kDa protein 1B

1

3

High-throughput

0.445

High

869190

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

Small-scale

0.437

High

1225003

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

1

High-throughput

0.437

High

159006

ZN195
Zinc finger protein 195

1

0

High-throughput

0.279

Low

720586

AA1R
Adenosine receptor A1

1

0

High-throughput

0.279

Low

1081546

Q0VDC6
peptidylprolyl isomerase

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025