Protein: PGH2
Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)

Gene: PGH2, PTGS2
Organism: Homo sapiens
Interactions: 56
UniProt ID: P35354

Gene Ontology (top 5):
GO:0001516 - prostaglandin biosynthetic process
GO:0004601 - peroxidase activity
GO:0004666 - prostaglandin-endoperoxide synthase activity
GO:0005637 - nuclear inner membrane
GO:0005640 - nuclear outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

770754

PGH2
Prostaglandin G/H synthase 2

4

2

Small-scale

0.896

High

770763

CAV1
Caveolin-1

4

2

Small-scale

0.705

High

413305

P53
Cellular tumor antigen p53

6

0

Small-scale

0.703

High

770765

EP300
Histone acetyltransferase p300

3

1

Small-scale

0.640

High

770774

ELAV1
ELAV-like protein 1

3

1

Small-scale

0.640

High

654818

PGH1
Prostaglandin G/H synthase 1

1

2

Small-scale

0.618

High

770761

SUMO1
Small ubiquitin-related modifier 1

3

0

Small-scale

0.613

High

770787

LMA2L
VIP36-like protein

2

0

High-throughput

0.602

High

770756

CEBPD
CCAAT/enhancer-binding protein delta

3

4

Small-scale

0.585

High

429405

JUN
Transcription factor Jun

2

2

Small-scale

0.584

High

770764

TF65
Transcription factor p65

2

2

Small-scale

0.584

High

770785

DERL1
Derlin-1

2

1

Small-scale

0.584

High

770790

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

Small-scale

0.578

High

770762

NUCB1
Nucleobindin-1

1

2

Small-scale

0.561

High

770781

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.554

High

770788

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.537

High

168643

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.518

High

770770

CUL1
Cullin-1

1

3

Small-scale

0.515

High

770783

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

Small-scale

0.515

High

770789

CSN3
COP9 signalosome complex subunit 3

1

1

Small-scale

0.515

High

770775

PTGIS
Prostacyclin synthase

1

2

Small-scale

0.501

High

409287

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.493

High

370588

FOS
Protein c-Fos

1

1

Small-scale

0.479

High

371323

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

606330

CEBPB
CCAAT/enhancer-binding protein beta

1

3

Small-scale

0.479

High

626101

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

Small-scale

0.479

High

691648

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.479

High

720647

AGTR1
Type-1 angiotensin II receptor

1

1

Small-scale

0.479

High

770758

HDAC4
Histone deacetylase 4

1

1

Small-scale

0.479

High

770766

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

770767

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

Small-scale

0.479

High

770771

CUL4A
Cullin-4A

1

3

Small-scale

0.479

High

770772

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

Small-scale

0.479

High

770786

DERL2
Derlin-2

1

1

Small-scale

0.479

High

770778

Q86V38
Atrophin 1

1

1

High-throughput

0.470

High

184397

SURF4
Surfeit locus protein 4

1

0

Small-scale

0.458

High

279122

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

421602

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.458

High

593035

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

770755

PA24A
Cytosolic phospholipase A2

1

0

Small-scale

0.458

High

770757

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

770759

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.458

High

770760

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

770768

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

770769

HDAC1
Histone deacetylase 1

1

0

Small-scale

0.458

High

770777

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

770779

ELMO1
Engulfment and cell motility protein 1

1

0

Small-scale

0.458

High

770780

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.458

High

770782

FAF2
FAS-associated factor 2

1

0

High-throughput

0.458

High

770784

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

238412

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.457

High

563320

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

762192

PE2R1
Prostaglandin E2 receptor EP1 subtype

1

1

Small-scale

0.437

High

770773

CASP8
Caspase-8

1

0

High-throughput

0.426

High

770776

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025