Protein: NUCB1
Nucleobindin-1 (CALNUC)

Gene: NUCB1
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q02818

Gene Ontology (top 5):
GO:0001965 - G-protein alpha-subunit binding
GO:0003677 - DNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005509 - calcium ion binding
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

469714

MMP3
Stromelysin-1

3

1

High-throughput

0.667

High

1038970

FGL1
Fibrinogen-like protein 1

3

1

High-throughput

0.667

High

1038989

PXL2B
Prostamide/prostaglandin F synthase

3

1

High-throughput

0.667

High

1009825

NUCB2
Nucleobindin-2

4

0

High-throughput

0.657

High

615177

PACA
Pituitary adenylate cyclase-activating polypeptide

3

0

High-throughput

0.638

High

1039008

DKKL1
Dickkopf-like protein 1

3

0

High-throughput

0.634

High

1039001

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.628

High

546967

FGF3
Fibroblast growth factor 3

2

0

High-throughput

0.602

High

1039000

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.602

High

640148

EPHA1
Ephrin type-A receptor 1

2

4

High-throughput

0.574

High

770762

PGH2
Prostaglandin G/H synthase 2

1

2

Small-scale

0.561

High

1039002

HINT3
Adenosine 5'-monophosphoramidase HINT3

2

1

High-throughput

0.549

High

1038986

FA20C
Extracellular serine/threonine protein kinase FAM20C

2

0

Small-scale

0.547

High

380281

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

2

High-throughput

0.536

High

480406

MMP10
Stromelysin-2

1

1

High-throughput

0.536

High

534955

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

731836

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.536

High

1039009

PA2GD
Group IID secretory phospholipase A2

1

1

High-throughput

0.536

High

1038988

CHSTD
Carbohydrate sulfotransferase 13

1

0

High-throughput

0.513

High

1038998

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.513

High

1038971

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.494

High

421958

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

627519

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

2

High-throughput

0.489

High

1038997

CSTL1
Cystatin-like 1

1

1

High-throughput

0.489

High

172720

XPO1
Exportin-1

1

1

High-throughput

0.481

High

418652

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

7

Small-scale

0.481

High

475953

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

7

High-throughput

0.481

High

989722

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

7

High-throughput

0.481

High

989832

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

7

High-throughput

0.481

High

1005351

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.480

High

218078

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

229696

CALU
Calumenin

1

2

High-throughput

0.479

High

566641

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.479

High

692934

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

951107

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

1038980

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1038985

DJC10
DnaJ homolog subfamily C member 10

1

5

High-throughput

0.479

High

1038991

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1038992

CALR3
Calreticulin-3

1

3

High-throughput

0.479

High

1038996

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

1

High-throughput

0.479

High

1039006

DNJ5B
DnaJ homolog subfamily C member 5B

1

2

High-throughput

0.479

High

371811

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.460

High

1029266

SET
Protein SET

1

0

High-throughput

0.460

High

408820

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

892549

DNLI3
DNA ligase 3

1

0

High-throughput

0.458

High

1038987

F184A
Protein FAM184A

1

0

High-throughput

0.458

High

380536

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

2

High-throughput

0.445

High

552945

PIP
Prolactin-inducible protein

1

1

High-throughput

0.445

High

1038977

NTCP5
Sodium/bile acid cotransporter 5

1

1

High-throughput

0.445

High

1038969

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.439

High

259820

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

298361

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.437

High

674141

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.437

High

948145

DJB13
DnaJ homolog subfamily B member 13

1

1

High-throughput

0.437

High

1038974

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.437

High

1038981

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1038993

SNX27
Sorting nexin-27

1

1

High-throughput

0.437

High

1038994

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.437

High

1038995

VRK1
Serine/threonine-protein kinase VRK1

1

3

High-throughput

0.437

High

1039003

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

1039005

DJC11
DnaJ homolog subfamily C member 11

1

1

High-throughput

0.437

High

1039007

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

529664

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

936984

CASP6
Caspase-6

1

5

Small-scale

0.407

High

1007668

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.407

High

1038973

CASP8
Caspase-8

1

5

Small-scale

0.407

High

1038976

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

1

High-throughput

0.407

High

1038990

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

0

High-throughput

0.305

High

885219

HXA1
Homeobox protein Hox-A1

1

0

High-throughput

0.282

High

416011

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.279

Low

416609

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.279

Low

1038979

CF015
Uncharacterized protein C6orf15

1

0

High-throughput

0.279

Low

1038983

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.279

Low

1038999

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.279

Low

1039004

TXLNG
Gamma-taxilin

1

0

High-throughput

0.279

Low

156029

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.269

Low

586275

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.251

Low

704945

RBL1
Retinoblastoma-like protein 1

1

0

High-throughput

0.251

Low

1038975

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

261156

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

593586

GDC
Solute carrier family 25 member 16

1

0

High-throughput

0.232

Low

653264

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

765415

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.232

Low

1038972

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.232

Low

1038978

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

1038982

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.232

Low

1038984

TRXR3
Thioredoxin reductase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025