Protein: COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (3-demethylubiquinone 3-O-methyltransferase) (EC 2.1.1.-) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)

Gene: COQ3
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q9NZJ6

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix
GO:0006071 - glycerol metabolic process
GO:0006744 - ubiquinone biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1453378

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

3

5

High-throughput

0.664

High

1453373

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

8

High-throughput

0.618

High

282114

MPPB
Mitochondrial-processing peptidase subunit beta

2

5

High-throughput

0.601

High

1162598

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

Small-scale

0.584

High

275121

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

2

High-throughput

0.561

High

885186

TTPA
Alpha-tocopherol transfer protein

2

1

High-throughput

0.553

High

649906

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

1

High-throughput

0.536

High

1207170

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.536

High

60528

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

0

High-throughput

0.513

High

1138901

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

471291

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

519256

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

1058330

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1092675

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

3

High-throughput

0.479

High

1205154

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

4

High-throughput

0.479

High

1341335

COQ8A
Atypical kinase COQ8A, mitochondrial

1

3

High-throughput

0.479

High

1387074

COQ8B
Atypical kinase COQ8B, mitochondrial

1

3

High-throughput

0.479

High

1407384

COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial

1

2

High-throughput

0.479

High

1453379

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

2

High-throughput

0.479

High

1453380

NFS1
Cysteine desulfurase

1

1

High-throughput

0.479

High

1453381

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

273115

CLU
Clustered mitochondria protein homolog

1

1

High-throughput

0.445

High

1083783

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.445

High

1255860

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

849044

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

0

High-throughput

0.316

High

1111985

SNX1
Sorting nexin-1

2

0

High-throughput

0.316

High

1453376

NDRG4
Protein NDRG4

2

0

High-throughput

0.316

High

1453375

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.313

High

164830

UN13B
Protein unc-13 homolog B

1

0

High-throughput

0.279

Low

668734

APC
Adenomatous polyposis coli protein

1

0

High-throughput

0.279

Low

725557

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

0

High-throughput

0.279

Low

876651

NEST
Nestin

1

0

High-throughput

0.279

Low

1322268

FCSK
L-fucose kinase

1

0

High-throughput

0.279

Low

1324665

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

0

High-throughput

0.279

Low

1333086

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

0

High-throughput

0.279

Low

1372015

LPP
Lipoma-preferred partner

1

0

High-throughput

0.279

Low

1387872

IP3KC
Inositol-trisphosphate 3-kinase C

1

0

High-throughput

0.279

Low

1408549

AKAP9
A-kinase anchor protein 9

1

0

High-throughput

0.279

Low

1418747

YTHD1
YTH domain-containing family protein 1

1

0

High-throughput

0.279

Low

1419381

SETD2
Histone-lysine N-methyltransferase SETD2

1

0

High-throughput

0.279

Low

1452429

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.279

Low

1453374

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.279

Low

1453377

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.279

Low

942930

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

1218028

MYOME
Myomegalin

1

0

High-throughput

0.249

Low

1446574

NXT2
NTF2-related export protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025