Protein: LGMN
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1)

Gene: LGMN
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q99538

Gene Ontology (top 5):
GO:0003014 - renal system process
GO:0004197 - cysteine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1154341

CYTM
Cystatin-M

3

3

Small-scale

0.879

High

370042

CYTC
Cystatin-C

2

3

Small-scale

0.840

High

1405109

FBX6
F-box only protein 6

4

3

High-throughput

0.683

High

334230

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

3

0

High-throughput

0.638

High

1405104

LGMN
Legumain

1

1

Small-scale

0.625

High

370227

CYTN
Cystatin-SN

1

3

Small-scale

0.618

High

1127936

PDIA5
Protein disulfide-isomerase A5

3

1

High-throughput

0.609

High

1405111

TRAF6
TNF receptor-associated factor 6

2

0

Small-scale

0.607

High

948013

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

1405110

FBX2
F-box only protein 2

2

3

High-throughput

0.601

High

409046

G3P
Glyceraldehyde-3-phosphate dehydrogenase

2

1

High-throughput

0.584

High

530266

TAU
Microtubule-associated protein tau

2

0

Small-scale

0.577

High

317365

ACL6B
Actin-like protein 6B

2

0

High-throughput

0.576

High

370352

CYTA
Cystatin-A

1

1

Small-scale

0.575

High

402795

CYTB
Cystatin-B

1

1

Small-scale

0.575

High

1029364

SET
Protein SET

1

0

Small-scale

0.537

High

647400

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.536

High

699039

CALX
Calnexin

1

2

High-throughput

0.536

High

922281

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

273780

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

0

High-throughput

0.513

High

361339

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

416643

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.513

High

1049703

1433F
14-3-3 protein eta

1

0

High-throughput

0.513

High

1248574

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

1248788

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.513

High

1310336

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1247082

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

1

Small-scale

0.512

High

725446

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.493

High

1006648

SRPK2
SRSF protein kinase 2

1

0

Small-scale

0.480

High

425609

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

1255207

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1405106

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1405112

LAMC3
Laminin subunit gamma-3

1

0

High-throughput

0.460

High

766783

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

791653

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

1114096

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1405107

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1405108

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

328121

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

218670

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

1082529

U17LO
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

1

1

High-throughput

0.407

High

1405105

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.407

High

292929

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.279

Low

911948

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.279

Low

1380924

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.279

Low

883063

AMPH
Amphiphysin

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025