Protein: NKG2D
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)

Gene: NKG2D, KLRK1
Organism: Homo sapiens
Interactions: 30
UniProt ID: P26718

Gene Ontology (top 5):
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002250 - adaptive immune response
GO:0005886 - plasma membrane
GO:0006809 - nitric oxide biosynthetic process
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688705

ULBP5
UL-16 binding protein 5

4

20

Small-scale

0.878

High

688707

RAE1E
Retinoic acid early transcript 1E

4

20

Small-scale

0.878

High

688710

ULBP3
UL16-binding protein 3

3

20

Small-scale

0.840

High

688703

ULBP6
UL16-binding protein 6

2

20

Small-scale

0.789

High

688699

MICA
MHC class I polypeptide-related sequence A

2

20

Small-scale

0.778

High

688711

ULBP2
UL16-binding protein 2

2

20

Small-scale

0.768

High

688692

NKG2D
NKG2-D type II integral membrane protein

1

17

Small-scale

0.647

High

688712

ULBP1
UL16-binding protein 1

1

20

Small-scale

0.647

High

688717

SE1L1
Protein sel-1 homolog 1

1

9

High-throughput

0.618

High

688716

HCST
Hematopoietic cell signal transducer

2

2

Small-scale

0.584

High

688693

CALX
Calnexin

1

20

High-throughput

0.536

High

688694

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

5

High-throughput

0.536

High

688697

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.536

High

688706

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

3

High-throughput

0.536

High

688708

PIGB
GPI alpha-1,2-mannosyltransferase 3

1

3

High-throughput

0.536

High

688714

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

6

High-throughput

0.536

High

229509

NRDC
Nardilysin

1

0

High-throughput

0.513

High

688700

SGMR2
Sigma intracellular receptor 2

1

0

High-throughput

0.513

High

688701

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

3

High-throughput

0.489

High

688702

DCA10
DDB1- and CUL4-associated factor 10

1

3

High-throughput

0.489

High

688704

DUS29
Dual specificity phosphatase 29

1

1

High-throughput

0.489

High

688709

RSPRY
RING finger and SPRY domain-containing protein 1

1

1

High-throughput

0.489

High

688713

REEP4
Receptor expression-enhancing protein 4

1

4

High-throughput

0.489

High

688698

PDE4C
3',5'-cyclic-AMP phosphodiesterase 4C

2

0

High-throughput

0.316

High

431387

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

0

High-throughput

0.279

Low

688695

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.279

Low

688715

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

688718

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

688696

RAE1L
mRNA export factor RAE1

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025