Protein: SC11A
Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)

Gene: SC11A, SEC11A
Organism: Homo sapiens
Interactions: 110
UniProt ID: P67812

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0008233 - peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

956044

SPCS3
Signal peptidase complex subunit 3

2

3

High-throughput

0.776

High

994914

SPCS2
Signal peptidase complex subunit 2

2

3

High-throughput

0.776

High

664037

PRTN3
Myeloblastin

2

3

High-throughput

0.601

High

994970

SPCS1
Signal peptidase complex subunit 1

2

3

High-throughput

0.601

High

994961

FBX6
F-box only protein 6

3

2

High-throughput

0.593

High

994959

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.578

High

994904

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

2

4

High-throughput

0.558

High

879999

DNSL1
Deoxyribonuclease-1-like 1

2

1

High-throughput

0.549

High

994932

FXL14
F-box/LRR-repeat protein 14

2

1

High-throughput

0.549

High

994968

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

2

3

High-throughput

0.549

High

994921

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.536

High

994942

NCLN
BOS complex subunit NCLN

1

1

High-throughput

0.536

High

994943

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

994964

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.536

High

220491

RNF13
E3 ubiquitin-protein ligase RNF13

1

0

High-throughput

0.513

High

698570

CALX
Calnexin

1

0

High-throughput

0.513

High

994907

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.513

High

178242

NPC1
NPC intracellular cholesterol transporter 1

2

1

High-throughput

0.504

High

132587

UPK1A
Uroplakin-1a

1

1

High-throughput

0.489

High

332627

LYPD3
Ly6/PLAUR domain-containing protein 3

1

1

High-throughput

0.489

High

994915

AMHR2
Anti-Muellerian hormone type-2 receptor

1

2

High-throughput

0.489

High

994919

ZACN
Ligand-gated cation channel ZACN

1

6

High-throughput

0.489

High

994956

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.489

High

994967

FBX2
F-box only protein 2

1

2

High-throughput

0.489

High

994971

WNT6
Protein Wnt-6

1

1

High-throughput

0.489

High

955044

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.479

High

961938

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

994906

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

994937

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

994909

Q08AM2
ADAM33 protein

1

3

High-throughput

0.470

High

994920

MKS3
Meckelin

1

0

High-throughput

0.458

High

994926

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

994935

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

994944

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

994947

MIA2
Melanoma inhibitory activity protein 2

1

2

High-throughput

0.445

High

994933

S35F6
Solute carrier family 35 member F6

1

1

High-throughput

0.439

High

994954

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

3

High-throughput

0.439

High

126540

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.437

High

403967

GCR
Glucocorticoid receptor

1

1

High-throughput

0.437

High

994918

TECT1
Tectonic-1

1

3

High-throughput

0.437

High

994925

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

994939

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

994945

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

994953

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

994958

RHOF
Rho-related GTP-binding protein RhoF

1

4

High-throughput

0.437

High

994922

S35D3
Solute carrier family 35 member D3

1

0

High-throughput

0.426

High

994923

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

248860

GSDME
Gasdermin-E

1

1

High-throughput

0.407

High

851106

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

3

High-throughput

0.407

High

855313

5HT3A
5-hydroxytryptamine receptor 3A

1

5

High-throughput

0.407

High

994908

ACVR1
Activin receptor type-1

1

1

High-throughput

0.407

High

994966

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

1

High-throughput

0.407

High

762296

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

2

0

High-throughput

0.328

High

441419

CHLE
Cholinesterase

2

0

High-throughput

0.316

High

994938

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.313

High

247817

NUPR1
Nuclear protein 1

2

0

Small-scale

0.300

High

647342

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.279

Low

688695

NKG2D
NKG2-D type II integral membrane protein

1

0

High-throughput

0.279

Low

733325

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

904228

P2RX1
P2X purinoceptor 1

1

0

High-throughput

0.279

Low

967297

TSN5
Tetraspanin-5

1

0

High-throughput

0.279

Low

994905

ASIC1
Acid-sensing ion channel 1

1

0

High-throughput

0.279

Low

994910

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.279

Low

994924

PVRIG
Transmembrane protein PVRIG

1

0

High-throughput

0.279

Low

994928

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

994936

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

994949

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.279

Low

994951

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.279

Low

994955

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.279

Low

994916

H31T
Histone H3.1t

1

0

High-throughput

0.269

Low

994941

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.269

Low

994902

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.251

Low

125400

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

157220

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

218044

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

254592

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

379998

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

540396

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.249

Low

566625

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

640844

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.249

Low

642794

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

729736

1433B
14-3-3 protein beta/alpha

1

0

High-throughput

0.249

Low

887951

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

904573

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

919880

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.249

Low

947157

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

958930

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

970299

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

974972

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.249

Low

994903

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

994912

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

994913

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

994917

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

994927

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

994929

LBN
Limbin

1

0

High-throughput

0.249

Low

994930

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

994940

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.249

Low

994946

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

994948

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

994952

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low

994960

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

994962

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

994963

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

994965

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

994969

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.249

Low

994911

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.232

Low

994931

S22A9
Organic anion transporter 7

1

0

High-throughput

0.232

Low

994934

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

994950

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

High-throughput

0.232

Low

994957

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025