Protein: NEST
Nestin

Gene: NEST, NES
Organism: Homo sapiens
Interactions: 149
UniProt ID: P48681

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0005737 - cytoplasm
GO:0005882 - intermediate filament
GO:0007417 - central nervous system development
GO:0007420 - brain development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

474543

VIME
Vimentin

7

20

High-throughput

0.967

High

451350

NFM
Neurofilament medium polypeptide

4

20

High-throughput

0.892

High

570376

GFAP
Glial fibrillary acidic protein

3

20

High-throughput

0.861

High

437122

K2C8
Keratin, type II cytoskeletal 8

2

20

High-throughput

0.776

High

833238

PERI
Peripherin

2

20

High-throughput

0.754

High

176334

SYNEM
Synemin

1

20

High-throughput

0.691

High

451129

NFL
Neurofilament light polypeptide

1

20

High-throughput

0.691

High

475748

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.691

High

606091

DESM
Desmin

1

20

High-throughput

0.691

High

876591

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.691

High

876593

AINX
Alpha-internexin

1

20

High-throughput

0.691

High

876640

K1C23
Keratin, type I cytoskeletal 23

1

20

High-throughput

0.691

High

876642

SYNCI
Syncoilin

1

20

High-throughput

0.691

High

575124

IDE
Insulin-degrading enzyme

3

13

Small-scale

0.670

High

876609

UBR1
E3 ubiquitin-protein ligase UBR1

2

6

High-throughput

0.628

High

876625

RSPRY
RING finger and SPRY domain-containing protein 1

2

17

High-throughput

0.628

High

876578

CDK5
Cyclin-dependent kinase 5

2

18

Small-scale

0.624

High

634346

LMNB1
Lamin-B1

1

20

High-throughput

0.618

High

436823

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

876627

F167A
Protein FAM167A

3

3

High-throughput

0.604

High

371448

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.585

High

658503

MYF6
Myogenic factor 6

2

7

High-throughput

0.574

High

581758

MYOG
Myogenin

2

6

High-throughput

0.558

High

220480

RNF13
E3 ubiquitin-protein ligase RNF13

1

17

High-throughput

0.536

High

244836

TRAK2
Trafficking kinesin-binding protein 2

1

20

High-throughput

0.536

High

325725

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.536

High

335438

SLU7
Pre-mRNA-splicing factor SLU7

1

2

High-throughput

0.536

High

336375

SVIL
Supervillin

1

11

High-throughput

0.536

High

457060

CAN1
Calpain-1 catalytic subunit

1

8

High-throughput

0.536

High

461263

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.536

High

612931

EGR1
Early growth response protein 1

1

14

High-throughput

0.536

High

774032

ADDA
Alpha-adducin

1

10

High-throughput

0.536

High

876572

ASCL1
Achaete-scute homolog 1

1

7

High-throughput

0.536

High

876581

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.536

High

876582

FLII
Protein flightless-1 homolog

1

11

High-throughput

0.536

High

876585

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.536

High

876592

STK11
Serine/threonine-protein kinase STK11

1

9

High-throughput

0.536

High

876594

HIF1A
Hypoxia-inducible factor 1-alpha

1

9

High-throughput

0.536

High

876597

GRDN
Girdin

1

20

High-throughput

0.536

High

876599

GRTP1
Growth hormone-regulated TBC protein 1

1

7

High-throughput

0.536

High

876610

UBR2
E3 ubiquitin-protein ligase UBR2

1

6

High-throughput

0.536

High

876633

PKP4
Plakophilin-4

1

16

High-throughput

0.536

High

876635

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.536

High

876638

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

17

High-throughput

0.536

High

876641

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

16

High-throughput

0.536

High

876647

XPP3
Xaa-Pro aminopeptidase 3

1

3

High-throughput

0.536

High

876652

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

High-throughput

0.536

High

876590

RBP1
RalA-binding protein 1

2

20

High-throughput

0.521

High

876608

ARHGJ
Rho guanine nucleotide exchange factor 19

2

20

High-throughput

0.521

High

876621

DEP1B
DEP domain-containing protein 1B

2

15

High-throughput

0.521

High

876643

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

2

High-throughput

0.515

High

552530

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.513

High

732262

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.513

High

834275

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.513

High

228691

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

15

High-throughput

0.489

High

248433

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

8

High-throughput

0.489

High

270628

ATP9A
Probable phospholipid-transporting ATPase IIA

1

1

High-throughput

0.489

High

334713

IPO7
Importin-7

1

8

High-throughput

0.489

High

447709

TPM3
Tropomyosin alpha-3 chain

1

8

High-throughput

0.489

High

482858

TPM1
Tropomyosin alpha-1 chain

1

10

High-throughput

0.489

High

483043

CLCA
Clathrin light chain A

1

4

High-throughput

0.489

High

483307

CLCB
Clathrin light chain B

1

4

High-throughput

0.489

High

587025

ITF2
Transcription factor 4

1

1

High-throughput

0.489

High

638594

ZNF10
Zinc finger protein 10

1

3

High-throughput

0.489

High

673760

LAMA1
Laminin subunit alpha-1

1

3

High-throughput

0.489

High

706085

S10A2
Protein S100-A2

1

20

High-throughput

0.489

High

841109

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.489

High

876576

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.489

High

876583

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

13

High-throughput

0.489

High

876595

T132A
Transmembrane protein 132A

1

1

High-throughput

0.489

High

876596

S35G1
Solute carrier family 35 member G1

1

3

High-throughput

0.489

High

876598

CE162
Centrosomal protein of 162 kDa

1

20

High-throughput

0.489

High

876603

FIGLA
Factor in the germline alpha

1

6

High-throughput

0.489

High

876607

CCD71
Coiled-coil domain-containing protein 71

1

1

High-throughput

0.489

High

876611

MILK2
MICAL-like protein 2

1

13

High-throughput

0.489

High

876612

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

14

High-throughput

0.489

High

876617

ZBT44
Zinc finger and BTB domain-containing protein 44

1

6

High-throughput

0.489

High

876619

CTCFL
Transcriptional repressor CTCFL

1

9

High-throughput

0.489

High

876623

NGN1
Neurogenin-1

1

8

High-throughput

0.489

High

876629

RN145
RING finger protein 145

1

11

High-throughput

0.489

High

876631

FER3L
Fer3-like protein

1

7

High-throughput

0.489

High

876637

SCRT1
Transcriptional repressor scratch 1

1

18

High-throughput

0.489

High

876645

GHC1
Mitochondrial glutamate carrier 1

1

4

High-throughput

0.489

High

876650

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.489

High

876653

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.489

High

157086

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

222818

PRC1
Protein regulator of cytokinesis 1

1

20

High-throughput

0.479

High

247254

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

20

High-throughput

0.479

High

247738

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

271979

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

330755

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

411561

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

413397

P53
Cellular tumor antigen p53

1

15

Small-scale

0.479

High

536730

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.479

High

629650

BTF3
Transcription factor BTF3

1

7

High-throughput

0.479

High

791174

SYUA
Alpha-synuclein

1

6

High-throughput

0.479

High

876573

MECP2
Methyl-CpG-binding protein 2

1

20

High-throughput

0.479

High

876574

PLK1
Serine/threonine-protein kinase PLK1

1

12

High-throughput

0.479

High

876577

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

11

High-throughput

0.479

High

876579

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

876580

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

876587

KEAP1
Kelch-like ECH-associated protein 1

1

10

Small-scale

0.479

High

876588

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

876589

CD5R1
Cyclin-dependent kinase 5 activator 1

1

1

Small-scale

0.479

High

876605

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

876615

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.479

High

876622

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

19

High-throughput

0.479

High

876644

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

876649

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

14

High-throughput

0.479

High

438028

CO5A2

1

1

High-throughput

0.470

High

876604

DYH12
Dynein axonemal heavy chain 12

1

12

High-throughput

0.470

High

876626

TNIP3
TNFAIP3-interacting protein 3

1

20

High-throughput

0.470

High

876586

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.458

High

708837

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

12

High-throughput

0.445

High

765241

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

876575

TERA
Transitional endoplasmic reticulum ATPase

1

15

High-throughput

0.445

High

876616

POC5
Centrosomal protein POC5

1

5

High-throughput

0.445

High

876620

CE192
Centrosomal protein of 192 kDa

1

2

High-throughput

0.445

High

876632

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.445

High

285824

SF3B1
Splicing factor 3B subunit 1

1

2

High-throughput

0.437

High

297512

PIAS1
E3 SUMO-protein ligase PIAS1

1

10

High-throughput

0.437

High

418006

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

693598

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.437

High

755853

MCM5
DNA replication licensing factor MCM5

1

19

High-throughput

0.437

High

876606

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.437

High

876613

SRRM1
Serine/arginine repetitive matrix protein 1

1

20

High-throughput

0.437

High

876618

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.437

High

876624

CHM4C
Charged multivesicular body protein 4c

1

10

High-throughput

0.437

High

876639

ACE2
Angiotensin-converting enzyme 2

1

13

High-throughput

0.437

High

876648

ANLN
Anillin

1

20

High-throughput

0.437

High

107401

F8W7C6
Ribosomal protein L10

1

2

High-throughput

0.407

High

107438

F8WC19
Splicing factor 3b subunit 1

1

1

High-throughput

0.407

High

254881

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.407

High

324102

CE152
Centrosomal protein of 152 kDa

1

18

High-throughput

0.407

High

876584

CTBP1
C-terminal-binding protein 1

1

9

High-throughput

0.407

High

876601

CP135
Centrosomal protein of 135 kDa

1

20

High-throughput

0.407

High

876630

CEP63
Centrosomal protein of 63 kDa

1

19

High-throughput

0.407

High

876634

ZBT18
Zinc finger and BTB domain-containing protein 18

1

10

High-throughput

0.407

High

96632

E9PAV9
G patch domain-containing protein 4

1

0

High-throughput

0.279

Low

134264

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.279

Low

260714

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

644477

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.279

Low

876600

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.279

Low

876602

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

876614

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.279

Low

876636

CMS1
Protein CMSS1

1

0

High-throughput

0.279

Low

876651

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

876628

FA81B
Protein FAM81B

1

0

High-throughput

0.269

Low

876646

COE2
Transcription factor COE2

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025