Protein: GSH0
Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)

Gene: GSH0, GCLM
Organism: Homo sapiens
Interactions: 55
UniProt ID: P48507

Gene Ontology (top 5):
GO:0004357 - glutamate-cysteine ligase activity
GO:0005829 - cytosol
GO:0006534 - cysteine metabolic process
GO:0006536 - glutamate metabolic process
GO:0006750 - glutathione biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

819391

GSH1
Glutamate--cysteine ligase catalytic subunit

4

5

Small-scale

0.704

High

499334

HEM4
Uroporphyrinogen-III synthase

3

0

High-throughput

0.638

High

566325

KPCA
Protein kinase C alpha type

2

1

High-throughput

0.628

High

819430

PAR12
Protein mono-ADP-ribosyltransferase PARP12

2

1

High-throughput

0.574

High

819426

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

528756

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

819421

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

819433

E41L5
Band 4.1-like protein 5

1

4

High-throughput

0.536

High

819419

STOX1
Storkhead-box protein 1

1

0

High-throughput

0.518

High

819424

IRF7
Interferon regulatory factor 7

1

0

High-throughput

0.518

High

819404

PCBP3
Poly(rC)-binding protein 3

1

1

High-throughput

0.515

High

819409

CUL3
Cullin-3

1

0

High-throughput

0.513

High

819437

RBX2
RING-box protein 2

1

0

High-throughput

0.513

High

819403

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

1

High-throughput

0.489

High

819429

SEM4C
Semaphorin-4C

1

3

High-throughput

0.489

High

373866

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

617472

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

819406

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

819412

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

819415

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.479

High

819425

OPTN
Optineurin

1

2

High-throughput

0.479

High

779000

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

819407

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

819413

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.458

High

819432

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

819438

TRM7
tRNA

1

0

High-throughput

0.458

High

787632

PI4KA
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.445

High

819417

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

401620

JUN
Transcription factor Jun

1

1

Small-scale

0.437

High

552195

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

650634

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

719936

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

819405

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

819414

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

819416

Q4LE69
1-phosphatidylinositol 4-kinase

1

4

High-throughput

0.437

High

819418

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

819420

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

819422

NIN
Ninein

1

1

High-throughput

0.437

High

819411

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

819408

UPAR
Urokinase plasminogen activator surface receptor

2

0

High-throughput

0.318

High

819435

TRPV5
Transient receptor potential cation channel subfamily V member 5

2

0

High-throughput

0.318

High

819439

OSGI1
Oxidative stress-induced growth inhibitor 1

2

0

High-throughput

0.316

High

819434

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.279

Low

819442

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

338112

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.249

Low

390765

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

819402

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

819410

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

819423

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

819427

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

819428

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.249

Low

819431

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

819436

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

819440

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

819441

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024