Protein: KS6A1
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)

Gene: KS6A1, RPS6KA1
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q15418

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004711 - ribosomal protein S6 kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658954

MK01
Mitogen-activated protein kinase 1

14

20

Small-scale

0.981

High

850655

KS6A3
Ribosomal protein S6 kinase alpha-3

6

15

High-throughput

0.949

High

931650

CSK2B
Casein kinase II subunit beta

5

7

High-throughput

0.925

High

1071640

KS6A2
Ribosomal protein S6 kinase alpha-2

5

16

High-throughput

0.925

High

1073425

CDC37
Hsp90 co-chaperone Cdc37

5

15

High-throughput

0.922

High

647587

MK03
Mitogen-activated protein kinase 3

4

20

Small-scale

0.887

High

431876

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

438193

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

639749

IKBA
NF-kappa-B inhibitor alpha

3

10

Small-scale

0.878

High

508016

FGFR1
Fibroblast growth factor receptor 1

3

20

Small-scale

0.867

High

412205

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.811

High

601517

FGFR2
Fibroblast growth factor receptor 2

2

20

High-throughput

0.789

High

804126

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.785

High

227531

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.754

High

350188

RASK
GTPase KRas

2

14

High-throughput

0.754

High

1033875

SNTB2
Beta-2-syntrophin

2

20

High-throughput

0.754

High

1073478

PDIP3
Polymerase delta-interacting protein 3

1

6

Small-scale

0.692

High

173895

MK13
Mitogen-activated protein kinase 13

1

20

High-throughput

0.691

High

272868

KS6A4
Ribosomal protein S6 kinase alpha-4

1

15

High-throughput

0.691

High

789116

FRK
Tyrosine-protein kinase FRK

1

20

High-throughput

0.691

High

845924

RB27A
Ras-related protein Rab-27A

1

2

High-throughput

0.691

High

1073426

AMHR2
Anti-Muellerian hormone type-2 receptor

1

4

High-throughput

0.691

High

1073427

PHKG1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

1

14

High-throughput

0.691

High

1073443

TLK2
Serine/threonine-protein kinase tousled-like 2

1

17

High-throughput

0.691

High

1073466

GWL
Serine/threonine-protein kinase greatwall

1

16

High-throughput

0.691

High

176191

PPM1G
Protein phosphatase 1G

1

5

High-throughput

0.656

High

708302

TTK
Dual specificity protein kinase TTK

1

19

High-throughput

0.656

High

1028664

SRSF5
Serine/arginine-rich splicing factor 5

1

11

High-throughput

0.656

High

380782

S100B
Protein S100-B

1

10

Small-scale

0.647

High

615217

S10A1
Protein S100-A1

1

10

Small-scale

0.647

High

618630

IF4B
Eukaryotic translation initiation factor 4B

1

6

Small-scale

0.647

High

835776

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.647

High

1073448

RPTOR
Regulatory-associated protein of mTOR

1

12

Small-scale

0.647

High

1073484

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

20

Small-scale

0.631

High

835063

TSC2
Tuberin

2

3

Small-scale

0.629

High

1024016

ACACA
Acetyl-CoA carboxylase 1

2

8

High-throughput

0.628

High

683368

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.624

High

591854

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.618

High

153131

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

17

High-throughput

0.618

High

338465

EGFR
Epidermal growth factor receptor

1

19

High-throughput

0.618

High

348674

RASN
GTPase NRas

1

14

High-throughput

0.618

High

349336

RASH
GTPase HRas

1

10

High-throughput

0.618

High

384892

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

488726

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.618

High

607975

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

681859

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

High-throughput

0.618

High

829449

PPM1F
Protein phosphatase 1F

1

4

High-throughput

0.618

High

1073422

KS6A1
Ribosomal protein S6 kinase alpha-1

1

15

High-throughput

0.618

High

1073440

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1073480

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.618

High

1073486

DJC11
DnaJ homolog subfamily C member 11

1

18

High-throughput

0.618

High

556872

CREB1
Cyclic AMP-responsive element-binding protein 1

2

6

Small-scale

0.595

High

1073498

CHSP1
Calcium-regulated heat-stable protein 1

1

5

Small-scale

0.586

High

296916

LTN1
E3 ubiquitin-protein ligase listerin

2

3

High-throughput

0.584

High

1073459

CBP
CREB-binding protein

2

13

Small-scale

0.584

High

962792

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.578

High

1049960

SCRIB
Protein scribble homolog

1

7

High-throughput

0.578

High

1073424

PKN2
Serine/threonine-protein kinase N2

1

18

Small-scale

0.575

High

1073431

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

1073436

IIGP5
Interferon-inducible GTPase 5

2

2

High-throughput

0.574

High

1073446

MISP
Mitotic interactor and substrate of PLK1

2

2

High-throughput

0.574

High

502133

BIP
Endoplasmic reticulum chaperone BiP

2

15

High-throughput

0.571

High

504119

HSP7C
Heat shock cognate 71 kDa protein

2

8

High-throughput

0.571

High

564080

HSP76
Heat shock 70 kDa protein 6

2

8

High-throughput

0.571

High

1073461

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

7

High-throughput

0.571

High

497071

TAU
Microtubule-associated protein tau

1

20

Small-scale

0.569

High

640249

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

9

Small-scale

0.563

High

1073470

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

2

15

Small-scale

0.563

High

840477

VASP
Vasodilator-stimulated phosphoprotein

1

7

Small-scale

0.561

High

931170

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.561

High

841387

TOB1
Protein Tob1

1

0

Small-scale

0.554

High

793321

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.553

High

127642

EF2K
Eukaryotic elongation factor 2 kinase

1

2

Small-scale

0.536

High

983430

MAD1
Max dimerization protein 1

1

5

Small-scale

0.536

High

1073502

CSDC2
Cold shock domain-containing protein C2

1

5

Small-scale

0.536

High

871909

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.536

High

946244

BASP1
Brain acid soluble protein 1

1

4

High-throughput

0.536

High

1052205

SRC8
Src substrate cortactin

1

8

High-throughput

0.536

High

1073499

TRRAP
Transformation/transcription domain-associated protein

1

20

High-throughput

0.536

High

863828

LIMK2
LIM domain kinase 2

1

7

Small-scale

0.527

High

1033837

SNTA1
Alpha-1-syntrophin

1

20

Small-scale

0.527

High

1046432

SNTB1
Beta-1-syntrophin

1

17

Small-scale

0.527

High

1073437

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

16

Small-scale

0.527

High

1073479

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

Small-scale

0.527

High

1073496

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

17

Small-scale

0.527

High

957402

IDD
Integral membrane protein DGCR2/IDD

2

3

High-throughput

0.521

High

660504

GRN
Progranulin

1

0

High-throughput

0.513

High

1073463

F136A
Protein FAM136A

1

0

High-throughput

0.513

High

1073475

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

1073477

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.513

High

326924

DDAH2
Putative hydrolase DDAH2

1

1

High-throughput

0.508

High

618090

COF1
Cofilin-1

1

2

High-throughput

0.508

High

690146

GBP2
Guanylate-binding protein 2

1

3

High-throughput

0.508

High

843210

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.508

High

868196

ATX3
Ataxin-3

1

2

High-throughput

0.508

High

874965

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.508

High

958811

EM55
55 kDa erythrocyte membrane protein

1

7

High-throughput

0.508

High

369662

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

386785

P53
Cellular tumor antigen p53

1

5

Small-scale

0.501

High

416623

S10A6
Protein S100-A6

1

10

Small-scale

0.501

High

638962

S100P
Protein S100-P

1

10

Small-scale

0.501

High

642947

S10A4
Protein S100-A4

1

10

Small-scale

0.501

High

776694

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.501

High

916603

RS6
Small ribosomal subunit protein eS6

1

10

Small-scale

0.501

High

1031532

ATM
Serine-protein kinase ATM

1

20

Small-scale

0.501

High

1073430

PDCD4
Programmed cell death protein 4

1

3

Small-scale

0.501

High

1073452

DPTOR
DEP domain-containing mTOR-interacting protein

1

3

Small-scale

0.501

High

1073460

BAD
Bcl2-associated agonist of cell death

1

6

Small-scale

0.501

High

1073469

RHG07
Rho GTPase-activating protein 7

1

5

Small-scale

0.501

High

1073485

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

4

Small-scale

0.501

High

1073465

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

1073482

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.486

High

215631

AKAP8
A-kinase anchor protein 8

1

5

Small-scale

0.479

High

224444

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

264204

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.479

High

302154

AP2A2
AP-2 complex subunit alpha-2

1

3

High-throughput

0.479

High

304177

UBR5
E3 ubiquitin-protein ligase UBR5

1

17

Small-scale

0.479

High

309703

KAT7
Histone acetyltransferase KAT7

1

1

High-throughput

0.479

High

487459

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

552801

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

643349

HMGB2
High mobility group protein B2

1

10

High-throughput

0.479

High

646913

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

651283

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

720538

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

882312

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.479

High

904590

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

982035

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1032421

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.479

High

1036408

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.479

High

1037241

TBB3
Tubulin beta-3 chain

1

17

High-throughput

0.479

High

1073429

WASC4
WASH complex subunit 4

1

2

High-throughput

0.479

High

1073445

CNDG2
Condensin-2 complex subunit G2

1

1

High-throughput

0.479

High

1073447

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.479

High

1073449

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.479

High

1073450

DOCK4
Dedicator of cytokinesis protein 4

1

6

High-throughput

0.479

High

1073451

ENAH
Protein enabled homolog

1

14

Small-scale

0.479

High

1073455

FRS2
Fibroblast growth factor receptor substrate 2

1

2

High-throughput

0.479

High

1073456

TSC1
Hamartin

1

16

Small-scale

0.479

High

1073458

HDAC2
Histone deacetylase 2

1

9

High-throughput

0.479

High

1073464

AP2M1
AP-2 complex subunit mu

1

6

High-throughput

0.479

High

1073468

SCLT1
Sodium channel and clathrin linker 1

1

15

High-throughput

0.479

High

1073473

DDX50
ATP-dependent RNA helicase DDX50

1

8

High-throughput

0.479

High

1073487

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.479

High

1073490

AKA7G
A-kinase anchor protein 7 isoform gamma

1

7

High-throughput

0.479

High

1073492

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1073500

DTNA
Dystrobrevin alpha

1

5

High-throughput

0.479

High

1073501

TELO2
Telomere length regulation protein TEL2 homolog

1

1

High-throughput

0.479

High

1073504

COPG1
Coatomer subunit gamma-1

1

5

High-throughput

0.479

High

1073505

AP4B1
AP-4 complex subunit beta-1

1

5

High-throughput

0.479

High

217262

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.458

High

352108

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

819413

GSH0
Glutamate--cysteine ligase regulatory subunit

1

0

High-throughput

0.458

High

866948

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.458

High

976720

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.458

High

1049424

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.458

High

1056503

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.458

High

661265

S10A2
Protein S100-A2

1

10

Small-scale

0.457

High

1052401

FLOT2
Flotillin-2

1

6

High-throughput

0.437

High

1073428

INF2
Inverted formin-2

1

3

High-throughput

0.437

High

1073439

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.437

High

1073441

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1073462

NCLN
BOS complex subunit NCLN

1

1

High-throughput

0.437

High

1073472

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.437

High

1073476

LMF2
Lipase maturation factor 2

1

1

High-throughput

0.437

High

1073493

GGA2
ADP-ribosylation factor-binding protein GGA2

1

4

Small-scale

0.437

High

1073497

AP3M1
AP-3 complex subunit mu-1

1

6

High-throughput

0.437

High

1073503

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

2

High-throughput

0.437

High

167086

ARHGB
Rho guanine nucleotide exchange factor 11

1

10

Small-scale

0.408

High

883917

SYJ2B
Synaptojanin-2-binding protein

1

15

Small-scale

0.408

High

942348

DLG4
Disks large homolog 4

1

11

Small-scale

0.408

High

1073434

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

14

Small-scale

0.408

High

1073442

GRASP
Protein TAMALIN

1

20

Small-scale

0.408

High

1073444

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

20

Small-scale

0.408

High

1073453

LNX1
E3 ubiquitin-protein ligase LNX

1

17

Small-scale

0.408

High

1073454

PAR3L
Partitioning defective 3 homolog B

1

14

Small-scale

0.408

High

1073467

SNX27
Sorting nexin-27

1

20

Small-scale

0.408

High

1073471

ERBIN
Erbin

1

4

Small-scale

0.408

High

1073481

PDZD7
PDZ domain-containing protein 7

1

16

Small-scale

0.408

High

1073488

SNTG2
Gamma-2-syntrophin

1

17

Small-scale

0.408

High

1073489

ARHGC
Rho guanine nucleotide exchange factor 12

1

9

Small-scale

0.408

High

1073491

WHRN
Whirlin

1

20

Small-scale

0.408

High

1073494

NEB1
Neurabin-1

1

19

Small-scale

0.408

High

1073495

PZRN3
E3 ubiquitin-protein ligase PDZRN3

1

17

Small-scale

0.408

High

1073457

HTRA1
Serine protease HTRA1

1

0

Small-scale

0.391

High

59889

GRD2I
Delphilin

1

3

Small-scale

0.373

High

1045392

SHRM2
Protein Shroom2

1

5

Small-scale

0.373

High

1073423

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

20

Small-scale

0.373

High

1073433

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

18

Small-scale

0.373

High

1073438

PZRN4
PDZ domain-containing RING finger protein 4

1

17

Small-scale

0.373

High

1073474

GORS1
Golgi reassembly-stacking protein 1

1

1

Small-scale

0.373

High

1073483

GORS2
Golgi reassembly-stacking protein 2

1

1

Small-scale

0.373

High

1073435

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

239267

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

1

0

High-throughput

0.249

Low

1073432

SGMR2
Sigma intracellular receptor 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024