Protein: GBA1
Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Beta-glucosylceramidase 1) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.-) (D-glucosyl-N-acylsphingosine glucohydrolase) (Glucosylceramidase beta 1) (Imiglucerase) (Lysosomal cholesterol glycosyltransferase) (Lysosomal galactosylceramidase) (EC 3.2.1.46) (Lysosomal glycosylceramidase)

Gene: GBA1
Organism: Homo sapiens
Interactions: 145
UniProt ID: P04062

Gene Ontology (top 5):
GO:0000423 - mitophagy
GO:0004336 - galactosylceramidase activity
GO:0004348 - glucosylceramidase activity
GO:0005102 - signaling receptor binding
GO:0005124 - scavenger receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402366

SCRB2
Lysosome membrane protein 2

4

1

Small-scale

0.683

High

402333

CALX
Calnexin

3

1

Small-scale

0.667

High

125981

RB27B
Ras-related protein Rab-27B

3

1

High-throughput

0.662

High

402324

ENPL
Endoplasmin

2

1

Small-scale

0.611

High

402337

SYUA
Alpha-synuclein

2

0

Small-scale

0.603

High

402328

TCPA
T-complex protein 1 subunit alpha

2

1

Small-scale

0.601

High

402345

RB27A
Ras-related protein Rab-27A

2

1

High-throughput

0.601

High

402315

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.586

High

402317

HS90A
Heat shock protein HSP 90-alpha

2

1

Small-scale

0.584

High

402368

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

2

Small-scale

0.561

High

402316

NTRK1
High affinity nerve growth factor receptor

2

0

Small-scale

0.559

High

402343

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.536

High

402344

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.536

High

402353

1433G
14-3-3 protein gamma

1

1

High-throughput

0.536

High

402358

1433F
14-3-3 protein eta

1

1

High-throughput

0.536

High

402439

HYOU1
Hypoxia up-regulated protein 1

1

2

High-throughput

0.536

High

165508

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.513

High

387643

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.513

High

402319

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

402372

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.513

High

402385

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

0

High-throughput

0.513

High

402392

INADL
InaD-like protein

1

0

High-throughput

0.513

High

402397

MYDGF
Myeloid-derived growth factor

1

0

High-throughput

0.513

High

402400

ERP27
Endoplasmic reticulum resident protein 27

1

0

High-throughput

0.513

High

402416

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

402431

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.513

High

402437

CNPY2
Protein canopy homolog 2

1

0

High-throughput

0.513

High

402341

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.501

High

402331

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.493

High

402377

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

2

High-throughput

0.489

High

402421

BMP2K
BMP-2-inducible protein kinase

1

1

High-throughput

0.489

High

185338

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

402335

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

402355

TBB4B
Tubulin beta-4B chain

1

3

Small-scale

0.479

High

402362

TBB3
Tubulin beta-3 chain

1

3

Small-scale

0.479

High

402364

TBB2A
Tubulin beta-2A chain

1

3

Small-scale

0.479

High

402370

EEA1
Early endosome antigen 1

1

2

Small-scale

0.479

High

402374

TBB8
Tubulin beta-8 chain

1

3

Small-scale

0.479

High

402375

AGK
Acylglycerol kinase, mitochondrial

1

1

Small-scale

0.479

High

402376

VP13D
Intermembrane lipid transfer protein VPS13D

1

1

Small-scale

0.479

High

402383

POTEE
POTE ankyrin domain family member E

1

1

Small-scale

0.479

High

402386

VP13C
Intermembrane lipid transfer protein VPS13C

1

1

Small-scale

0.479

High

402401

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

402424

ARL8B
ADP-ribosylation factor-like protein 8B

1

1

High-throughput

0.479

High

402433

MYH13
Myosin-13

1

1

Small-scale

0.479

High

402434

RAB21
Ras-related protein Rab-21

1

1

High-throughput

0.479

High

133721

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

217695

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

240451

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.458

High

402322

3BHS1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

1

0

Small-scale

0.458

High

402325

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.458

High

402327

HSP76
Heat shock 70 kDa protein 6

1

0

Small-scale

0.458

High

402330

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.458

High

402347

CATC
Dipeptidyl peptidase 1

1

0

Small-scale

0.458

High

402348

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

402351

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

402352

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.458

High

402378

DEN4C
DENN domain-containing protein 4C

1

0

Small-scale

0.458

High

402388

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

402398

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

402409

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

402415

SG196
Protein O-mannose kinase

1

0

High-throughput

0.458

High

402422

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

170606

CLGN
Calmegin

1

1

High-throughput

0.445

High

402338

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.445

High

65921

POTEM
Putative POTE ankyrin domain family member M

1

2

Small-scale

0.437

High

72909

FHAD1
Forkhead-associated domain-containing protein 1

1

2

Small-scale

0.437

High

176925

CE290
Centrosomal protein of 290 kDa

1

1

Small-scale

0.437

High

402321

MYH8
Myosin-8

1

1

Small-scale

0.437

High

402354

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.437

High

402382

TBA3E
Tubulin alpha-3E chain

1

1

Small-scale

0.437

High

402393

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.437

High

402404

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.437

High

402414

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

402320

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.426

High

402334

GSTT1
Glutathione S-transferase theta-1

1

0

High-throughput

0.426

High

402361

TRDN
Triadin

1

0

High-throughput

0.426

High

402407

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.426

High

402410

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.426

High

402430

PI4KB
Phosphatidylinositol 4-kinase beta

1

0

Small-scale

0.426

High

402350

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

402379

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.407

High

402428

VGLU1
Vesicular glutamate transporter 1

1

1

High-throughput

0.407

High

402429

VGLU2
Vesicular glutamate transporter 2

1

1

High-throughput

0.407

High

66860

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

352283

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.279

Low

402329

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

402339

MTREX
Exosome RNA helicase MTR4

1

0

High-throughput

0.279

Low

402346

KS6A3
Ribosomal protein S6 kinase alpha-3

1

0

High-throughput

0.279

Low

402360

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.279

Low

402371

ZMY11
Zinc finger MYND domain-containing protein 11

1

0

High-throughput

0.279

Low

402380

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

0

High-throughput

0.279

Low

402381

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.279

Low

402402

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

0

High-throughput

0.279

Low

402417

JPH1
Junctophilin-1

1

0

High-throughput

0.279

Low

402423

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

High-throughput

0.279

Low

402435

GUC1B
Guanylyl cyclase-activating protein 2

1

0

High-throughput

0.279

Low

60761

MEIOC
Meiosis-specific coiled-coil domain-containing protein MEIOC

1

0

Small-scale

0.249

Low

245402

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.249

Low

293029

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

336314

SVIL
Supervillin

1

0

Small-scale

0.249

Low

402323

GFAP
Glial fibrillary acidic protein

1

0

Small-scale

0.249

Low

402326

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

402332

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

402336

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

402340

KI67
Proliferation marker protein Ki-67

1

0

Small-scale

0.249

Low

402349

UDB15
UDP-glucuronosyltransferase 2B15

1

0

Small-scale

0.249

Low

402356

RAE1L
mRNA export factor RAE1

1

0

Small-scale

0.249

Low

402357

IRX5
Iroquois-class homeodomain protein IRX-5

1

0

Small-scale

0.249

Low

402359

EF1A2
Elongation factor 1-alpha 2

1

0

Small-scale

0.249

Low

402363

DGKZ
Diacylglycerol kinase zeta

1

0

Small-scale

0.249

Low

402365

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.249

Low

402367

ZN273
Zinc finger protein 273

1

0

Small-scale

0.249

Low

402369

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

Small-scale

0.249

Low

402373

IAH1
Isoamyl acetate-hydrolyzing esterase 1 homolog

1

0

Small-scale

0.249

Low

402384

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

402387

GPBP1
Vasculin

1

0

Small-scale

0.249

Low

402390

FMR1N
FMR1 neighbor protein

1

0

Small-scale

0.249

Low

402391

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

402394

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.249

Low

402399

RHDF1
Inactive rhomboid protein 1

1

0

Small-scale

0.249

Low

402403

CFA44
Cilia- and flagella-associated protein 44

1

0

Small-scale

0.249

Low

402405

EYA1
Protein phosphatase EYA1

1

0

High-throughput

0.249

Low

402412

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

0

Small-scale

0.249

Low

402413

SNX25
Sorting nexin-25

1

0

Small-scale

0.249

Low

402419

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

402420

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.249

Low

402426

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

402427

JCAD
Junctional cadherin 5-associated protein

1

0

Small-scale

0.249

Low

402432

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.249

Low

402438

ZN175
Zinc finger protein 175

1

0

Small-scale

0.249

Low

402440

SPIN1
Spindlin-1

1

0

Small-scale

0.249

Low

402441

S12A7
Solute carrier family 12 member 7

1

0

Small-scale

0.249

Low

402318

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

0

High-throughput

0.232

Low

402342

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

0

High-throughput

0.232

Low

402389

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.232

Low

402395

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.232

Low

402396

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low

402406

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.232

Low

402408

S35A5
UDP-sugar transporter protein SLC35A5

1

0

High-throughput

0.232

Low

402411

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.232

Low

402418

S52A3
Solute carrier family 52, riboflavin transporter, member 3

1

0

High-throughput

0.232

Low

402425

ASF1B
Histone chaperone ASF1B

1

0

High-throughput

0.232

Low

402436

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025