Protein: MET18
DNA repair/transcription protein MET18/MMS19 (Methyl methanesulfonate-sensitivity protein 19)

Gene: MET18
Organism: Saccharomyces cerevisiae S288C
Interactions: 75
UniProt ID: P40469

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006281 - DNA repair
GO:0016226 - iron-sulfur cluster assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

805668

YHS2
MIP18 family protein YHR122W

11

3

Small-scale

0.755

High

825047

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

8

2

Small-scale

0.743

High

449349

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

5

4

Small-scale

0.718

High

545129

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.576

High

825030

MET18
DNA repair/transcription protein MET18/MMS19

1

1

Small-scale

0.575

High

394624

EF1A
Elongation factor 1-alpha

2

0

High-throughput

0.559

High

590644

HSP26
Heat shock protein 26

2

0

High-throughput

0.559

High

526866

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

752338

HSP78
Heat shock protein 78, mitochondrial

2

0

High-throughput

0.547

High

365637

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.536

High

367048

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.536

High

365069

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

454737

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

High-throughput

0.513

High

459104

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.513

High

486207

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.513

High

644631

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.513

High

738657

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.513

High

797964

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.513

High

814206

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.513

High

825046

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.513

High

405101

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.500

High

603489

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.489

High

736108

ARP2
Actin-related protein 2

1

1

High-throughput

0.489

High

825053

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.486

High

671647

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.479

High

825033

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.479

High

825039

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.479

High

825040

ACT
Actin

1

0

High-throughput

0.479

High

579521

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

707289

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

806112

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

1

High-throughput

0.479

High

825043

RLI1
Translation initiation factor RLI1

1

1

High-throughput

0.479

High

825048

NTH2
Endonuclease III homolog 2

1

2

High-throughput

0.479

High

825051

MLH3
DNA mismatch repair protein MLH3

1

3

High-throughput

0.479

High

383735

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

435139

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

454219

LEUC
3-isopropylmalate dehydratase

1

0

Small-scale

0.458

High

674664

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

753409

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

778364

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

795721

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

813552

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.458

High

825035

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

825041

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

825045

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

825049

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

825052

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

392844

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

524162

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

592294

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

659347

NAR1
Cytosolic Fe-S cluster assembly factor NAR1

1

2

Small-scale

0.445

High

739388

ZUO1
Zuotin

1

1

High-throughput

0.445

High

741710

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

811457

XDJ1
DnaJ protein homolog XDJ1

1

2

High-throughput

0.445

High

761119

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.438

High

825038

MDG1
Signal transduction protein MDG1

1

0

High-throughput

0.438

High

825042

CWC27
Peptidyl-prolyl isomerase CWC27

1

0

High-throughput

0.438

High

825050

YP191
Ubiquitin carboxyl-terminal hydrolase MIY1

1

0

High-throughput

0.438

High

386736

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

453633

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

471409

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.426

High

645614

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

734117

EF2
Elongation factor 2

1

0

High-throughput

0.426

High

804213

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

824450

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

825032

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

825034

YAE1
Protein YAE1

1

0

Small-scale

0.426

High

825036

MPA43
Protein MPA43

1

0

High-throughput

0.426

High

825037

LTO1
Protein LTO1

1

0

Small-scale

0.426

High

825044

YM44
Uncharacterized protein YMR178W

1

0

High-throughput

0.426

High

825031

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

2

High-throughput

0.407

High

479985

PRTB
Cerevisin

1

0

High-throughput

0.279

Low

795027

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

807813

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025