Protein: MAD1
Spindle assembly checkpoint component MAD1 (Mitotic arrest deficient protein 1)

Gene: MAD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: P40957

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0006913 - nucleocytoplasmic transport
GO:0007094 - mitotic spindle assembly checkpoint signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

829775

MAD2
Mitotic spindle checkpoint component MAD2

8

1

Small-scale

0.976

High

686915

BUB3
Spindle assembly checkpoint protein BUB3

4

19

Small-scale

0.697

High

829776

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

3

15

Small-scale

0.674

High

829774

MAD1
Spindle assembly checkpoint component MAD1

1

19

High-throughput

0.656

High

826564

DSN1
Kinetochore-associated protein DSN1

3

0

Small-scale

0.613

High

684625

CDC20
APC/C activator protein CDC20

2

19

Small-scale

0.590

High

829793

ATG17
Autophagy-related protein 17

2

0

High-throughput

0.570

High

829794

HDA2
HDA1 complex subunit 2

2

0

High-throughput

0.570

High

829791

NUP53
Nucleoporin NUP53

2

0

Small-scale

0.569

High

829787

CDC14
Tyrosine-protein phosphatase CDC14

1

13

Small-scale

0.561

High

524227

HSP71
Heat shock protein SSA1

2

11

High-throughput

0.552

High

745651

ORC2
Origin recognition complex subunit 2

1

3

Small-scale

0.541

High

545206

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.536

High

747735

SMC1
Structural maintenance of chromosomes protein 1

1

14

High-throughput

0.508

High

829786

MPS1
Serine/threonine-protein kinase MPS1

1

20

Small-scale

0.501

High

816995

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.486

High

438309

NOT3
General negative regulator of transcription subunit 3

1

1

High-throughput

0.481

High

597169

BIP
Endoplasmic reticulum chaperone BiP

1

15

High-throughput

0.481

High

750694

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.481

High

777062

BDF1
Bromodomain-containing factor 1

1

20

High-throughput

0.481

High

829778

GZF3
Protein GZF3

1

1

High-throughput

0.481

High

829788

PRS8
26S proteasome regulatory subunit 8 homolog

1

3

High-throughput

0.481

High

829789

SPP1
COMPASS component SPP1

1

5

High-throughput

0.481

High

829790

FCP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

5

High-throughput

0.481

High

829795

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

3

High-throughput

0.481

High

707348

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

735018

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

749681

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

829783

MPS2
Monopolar spindle protein 2

1

0

High-throughput

0.460

High

829796

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

781941

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

829782

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

Small-scale

0.458

High

829784

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.458

High

829792

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.458

High

392880

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.445

High

526921

HSP72
Heat shock protein SSA2

1

11

High-throughput

0.445

High

676076

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

727102

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

741759

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

804231

SSZ1
Ribosome-associated complex subunit SSZ1

1

10

High-throughput

0.445

High

811328

CAJ1
Protein CAJ1

1

5

High-throughput

0.445

High

724297

ZIP1
Synaptonemal complex protein ZIP1

1

17

High-throughput

0.439

High

735634

SMY1
Kinesin-related protein SMY1

1

18

High-throughput

0.439

High

736990

CDC3
Cell division control protein 3

1

7

High-throughput

0.439

High

753102

NIP80
Protein NIP100

1

20

High-throughput

0.439

High

758104

CASP
Protein CASP

1

19

High-throughput

0.439

High

779488

YKT6
Synaptobrevin homolog YKT6

1

3

High-throughput

0.439

High

779767

DYHC
Dynein heavy chain, cytoplasmic

1

11

High-throughput

0.439

High

804901

LAM4
Membrane-anchored lipid-binding protein LAM4

1

2

High-throughput

0.439

High

806296

KOG1
Target of rapamycin complex 1 subunit KOG1

1

15

High-throughput

0.439

High

817726

TSC11
Target of rapamycin complex 2 subunit TSC11

1

4

High-throughput

0.439

High

829779

GCN20
Protein GCN20

1

3

High-throughput

0.439

High

829781

MDV1
Mitochondrial division protein 1

1

19

High-throughput

0.439

High

829785

AP18B
Clathrin coat assembly protein AP180B

1

8

High-throughput

0.439

High

358246

ADH1
Alcohol dehydrogenase 1

1

1

High-throughput

0.407

High

600693

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.251

Low

796320

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

829780

STB2
Protein STB2

1

0

High-throughput

0.251

Low

829797

MPD2
Protein disulfide isomerase MPD2

1

0

High-throughput

0.251

Low

829798

HPH1
Protein HPH1

1

0

High-throughput

0.251

Low

829777

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025