Protein: ESP1
Separin (EC 3.4.22.49) (Separase)

Gene: ESP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: Q03018

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

771545

SECU
Securin

12

0

Small-scale

0.930

High

974318

SLK19
Kinetochore protein SLK19

2

1

Small-scale

0.601

High

974322

SCC1
Sister chromatid cohesion protein 1

2

2

Small-scale

0.595

High

959815

2ABA
Protein phosphatase PP2A regulatory subunit B

2

0

Small-scale

0.576

High

861204

RAGCD
GTP-binding protein GTR2

2

0

High-throughput

0.563

High

693151

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

Small-scale

0.515

High

837555

ZDS1
Protein ZDS1

1

1

Small-scale

0.515

High

764121

RV167
Reduced viability upon starvation protein 167

1

1

Small-scale

0.508

High

618857

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

2

Small-scale

0.501

High

697707

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.493

High

339807

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.480

High

343144

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.479

High

343851

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

375489

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

389130

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

411248

LEU1
2-isopropylmalate synthase

1

1

High-throughput

0.479

High

416064

DED1
ATP-dependent RNA helicase DED1

1

1

High-throughput

0.479

High

501406

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.479

High

520641

YPK1
Serine/threonine-protein kinase YPK1

1

1

High-throughput

0.479

High

546208

SYKC
Lysine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

560776

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

593688

DBP4
ATP-dependent RNA helicase HCA4

1

2

High-throughput

0.479

High

619166

SPT6
Transcription elongation factor SPT6

1

1

High-throughput

0.479

High

624224

DBP1
ATP-dependent RNA helicase DBP1

1

1

High-throughput

0.479

High

635630

PWP2
Periodic tryptophan protein 2

1

1

High-throughput

0.479

High

643692

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

676316

XPO1
Exportin-1

1

1

High-throughput

0.479

High

692603

ZUO1
Zuotin

1

3

High-throughput

0.479

High

693351

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.479

High

703951

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.479

High

704063

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

2

High-throughput

0.479

High

707915

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.479

High

737206

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

750758

YPT31
GTP-binding protein YPT31/YPT8

1

1

High-throughput

0.479

High

753244

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.479

High

753927

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

758927

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

1

High-throughput

0.479

High

767077

ARB1
ABC transporter ATP-binding protein ARB1

1

2

High-throughput

0.479

High

810905

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.479

High

974317

SUB2
ATP-dependent RNA helicase SUB2

1

1

High-throughput

0.479

High

974319

NEW1
[NU+] prion formation protein 1

1

3

High-throughput

0.479

High

974320

MDN1
Midasin

1

1

High-throughput

0.479

High

974324

LEU9
2-isopropylmalate synthase 2, mitochondrial

1

1

High-throughput

0.479

High

974328

GLT1
Glutamate synthase [NADH]

1

1

High-throughput

0.479

High

579813

SNF6
Transcription regulatory protein SNF6

1

0

High-throughput

0.460

High

343202

TRP
Tryptophan synthase

1

0

High-throughput

0.458

High

404366

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

410507

CYSD
Homocysteine/cysteine synthase

1

0

High-throughput

0.458

High

423481

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.458

High

427289

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.458

High

440088

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.458

High

440911

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.458

High

450502

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

500659

AK
Aspartokinase

1

0

High-throughput

0.458

High

509201

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.458

High

519622

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

521042

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

526353

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.458

High

531691

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.458

High

558670

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

561901

TUP1
General transcriptional corepressor TUP1

1

0

High-throughput

0.458

High

570719

HXKG
Glucokinase-1

1

0

High-throughput

0.458

High

593779

DBP5
ATP-dependent RNA helicase DBP5

1

0

High-throughput

0.458

High

597889

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.458

High

599191

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

High-throughput

0.458

High

599503

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.458

High

602743

MCK1
Protein kinase MCK1

1

0

High-throughput

0.458

High

605135

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

608721

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.458

High

641046

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

657177

PYRD
Dihydroorotate dehydrogenase

1

0

High-throughput

0.458

High

657273

URA7
CTP synthase 1

1

0

High-throughput

0.458

High

668093

TRXB1
Thioredoxin reductase 1

1

0

High-throughput

0.458

High

669875

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.458

High

675552

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.458

High

675775

RENT1
ATP-dependent helicase NAM7

1

0

High-throughput

0.458

High

687655

OAC1
Mitochondrial oxaloacetate transport protein

1

0

High-throughput

0.458

High

690699

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

691760

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.458

High

692245

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

0

High-throughput

0.458

High

693420

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.458

High

696469

FIMB
Fimbrin

1

0

High-throughput

0.458

High

703104

MRT4
Ribosome assembly factor MRT4

1

0

High-throughput

0.458

High

710207

NCBP1
Nuclear cap-binding protein complex subunit 1

1

0

High-throughput

0.458

High

731010

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.458

High

734861

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

741205

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.458

High

742056

NOP4
Nucleolar protein 4

1

0

High-throughput

0.458

High

742671

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.458

High

743831

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

744273

ADH5
Alcohol dehydrogenase 5

1

0

High-throughput

0.458

High

747029

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

High-throughput

0.458

High

751230

NCB5R
NADH-cytochrome b5 reductase 1

1

0

High-throughput

0.458

High

751414

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.458

High

752966

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.458

High

756094

ARO9
Aromatic amino acid aminotransferase 2

1

0

High-throughput

0.458

High

758598

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.458

High

765045

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

765369

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

766013

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

768398

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

0

High-throughput

0.458

High

770302

CCS1
Superoxide dismutase 1 copper chaperone

1

0

High-throughput

0.458

High

775158

GVP36
Protein GVP36

1

0

High-throughput

0.458

High

777100

SYA
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

826561

LYS4
Homoaconitase, mitochondrial

1

0

High-throughput

0.458

High

857274

ACS2
Acetyl-coenzyme A synthetase 2

1

0

High-throughput

0.458

High

859265

INO80
Chromatin-remodeling ATPase INO80

1

0

High-throughput

0.458

High

859416

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.458

High

865449

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.458

High

865825

RIA1
Ribosome assembly protein 1

1

0

High-throughput

0.458

High

945793

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.458

High

962622

ACAC
Acetyl-CoA carboxylase

1

0

High-throughput

0.458

High

974309

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

974310

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.458

High

974311

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.458

High

974312

YHM2
Citrate/oxoglutarate carrier protein

1

0

High-throughput

0.458

High

974315

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

974316

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

974323

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.458

High

974325

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.458

High

974326

IQG1
Ras GTPase-activating-like protein IQG1

1

0

High-throughput

0.458

High

974329

SEY1
Protein SEY1

1

0

High-throughput

0.458

High

492219

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

512463

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

633510

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

754653

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

760676

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.445

High

450334

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

546782

SEC23
Protein transport protein SEC23

1

1

High-throughput

0.437

High

578561

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.437

High

629654

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.437

High

750145

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.437

High

755406

SFB3
SED5-binding protein 3

1

2

High-throughput

0.437

High

760940

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.437

High

772920

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.437

High

774438

SEC24
Protein transport protein SEC24

1

2

High-throughput

0.437

High

784415

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.437

High

796932

GCN20
Protein GCN20

1

2

High-throughput

0.437

High

797714

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

3

High-throughput

0.437

High

852229

YPT32
GTP-binding protein YPT32/YPT11

1

1

High-throughput

0.437

High

861461

6PGD2
6-phosphogluconate dehydrogenase, decarboxylating 2

1

1

High-throughput

0.437

High

863627

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

970949

MLP1
Protein MLP1

1

1

High-throughput

0.437

High

972477

PDR12
ATP-dependent permease PDR12

1

2

High-throughput

0.437

High

974313

PDR15
ATP-dependent permease PDR15

1

2

High-throughput

0.437

High

366777

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

854662

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

692892

SPT16
FACT complex subunit SPT16

2

0

High-throughput

0.305

High

474404

YL016
Putative truncated guanine nucleotide exchange factor SDC25

1

0

High-throughput

0.261

Low

357557

RLA4
Large ribosomal subunit protein P2B

1

0

High-throughput

0.249

Low

378389

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.249

Low

410170

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.249

Low

481408

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

503019

SEC7
Protein transport protein SEC7

1

0

High-throughput

0.249

Low

540145

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.249

Low

604460

CLH
Clathrin heavy chain

1

0

High-throughput

0.249

Low

628726

PHO84
Inorganic phosphate transporter PHO84

1

0

High-throughput

0.249

Low

630971

USO1
Intracellular protein transport protein USO1

1

0

High-throughput

0.249

Low

685563

COPG
Coatomer subunit gamma

1

0

High-throughput

0.249

Low

689010

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.249

Low

690796

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low

690967

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

0

High-throughput

0.249

Low

709346

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.249

Low

741399

GLY1
Low specificity L-threonine aldolase

1

0

High-throughput

0.249

Low

784349

COPB
Coatomer subunit beta

1

0

High-throughput

0.249

Low

797350

VTC2
Vacuolar transporter chaperone complex subunit 2

1

0

High-throughput

0.249

Low

866037

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.249

Low

974314

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.249

Low

974321

GET3
ATPase GET3

1

0

High-throughput

0.249

Low

974327

ERG27
3-keto-steroid reductase ERG27

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024