Protein: MPS1
Serine/threonine-protein kinase MPS1 (EC 2.7.12.2) (Monopolar spindle protein 1) (Regulatory cell proliferation kinase 1)

Gene: MPS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P54199

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926705

MPS1
Serine/threonine-protein kinase MPS1

5

16

Small-scale

0.912

High

445360

CDC31
Cell division control protein 31

3

9

Small-scale

0.853

High

824862

NDC80
Kinetochore protein NDC80

7

20

Small-scale

0.750

High

393158

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.724

High

755278

NUF2
Kinetochore protein NUF2

5

5

Small-scale

0.713

High

709444

HRR25
Casein kinase I homolog HRR25

1

16

High-throughput

0.691

High

734617

NUD1
Protein NUD1

1

17

High-throughput

0.691

High

926711

SPC24
Kinetochore protein SPC24

4

1

Small-scale

0.689

High

826733

DSN1
Kinetochore-associated protein DSN1

4

1

Small-scale

0.686

High

850690

CENPT
Inner kinetochore subunit CNN1

5

0

Small-scale

0.681

High

917726

KNL1
Outer kinetochore KNL1 complex subunit SPC105

4

0

Small-scale

0.667

High

736036

SP110
Spindle pole body component 110

3

20

Small-scale

0.664

High

438217

CDC37
Hsp90 co-chaperone Cdc37

1

13

Small-scale

0.656

High

825292

MOB1
DBF2 kinase activator protein MOB1

2

3

Small-scale

0.649

High

671001

SIS1
Protein SIS1

1

11

High-throughput

0.647

High

694157

CDC15
Cell division control protein 15

1

17

High-throughput

0.647

High

800620

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

20

High-throughput

0.647

High

835515

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

1

19

Small-scale

0.647

High

926716

PML1
Pre-mRNA leakage protein 1

1

2

High-throughput

0.647

High

780977

SPC42
Spindle pole body component SPC42

2

1

Small-scale

0.639

High

926719

SGO1
Shugoshin

2

1

Small-scale

0.624

High

449162

CALM
Calmodulin

1

5

High-throughput

0.618

High

917621

MLC1
Myosin light chain 1

1

5

High-throughput

0.618

High

739996

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

18

Small-scale

0.618

High

926721

NBP2
NAP1-binding protein 2

2

1

High-throughput

0.614

High

753032

SPC29
Spindle pole component 29

2

0

Small-scale

0.592

High

817018

SPC25
Kinetochore protein SPC25

2

0

Small-scale

0.592

High

711515

BEM1
Bud emergence protein 1

2

8

High-throughput

0.586

High

813832

MBO1
Gamma tubulin complex adapter SPC72

2

1

Small-scale

0.585

High

924818

DMA2
E3 ubiquitin-protein ligase DMA2

1

2

High-throughput

0.579

High

524820

HSP71
Heat shock protein SSA1

2

20

High-throughput

0.571

High

744903

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

4

High-throughput

0.568

High

448466

RAD52
DNA repair and recombination protein RAD52

1

2

Small-scale

0.561

High

864270

ALY2
Arrestin-related trafficking adapter 3

2

5

High-throughput

0.550

High

763750

CENPC
Inner kinetochore subunit MIF2

1

1

High-throughput

0.536

High

782675

ESL2
EST/SMG-like protein 2

1

1

High-throughput

0.536

High

797900

CENPU
Inner kinetochore subunit AME1

1

1

High-throughput

0.536

High

865475

BFA1
Mitotic check point protein BFA1

1

1

High-throughput

0.536

High

926720

NSL1
Kinetochore-associated protein NSL1

1

1

High-throughput

0.536

High

926723

SFI1
Protein SFI1

1

1

High-throughput

0.536

High

739437

ZUO1
Zuotin

1

9

High-throughput

0.514

High

814084

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.513

High

866054

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.513

High

919459

CENPQ
Inner kinetochore subunit OKP1

1

0

High-throughput

0.513

High

926708

RPM2
Ribonuclease P protein component, mitochondrial

1

0

High-throughput

0.513

High

926725

NKP1
Inner kinetochore subunit NKP1

1

0

High-throughput

0.513

High

926726

CENPI
Inner kinetochore subunit CTF3

1

0

High-throughput

0.513

High

382268

H4
Histone H4

1

7

Small-scale

0.501

High

816970

BIM1
Protein BIM1

1

4

Small-scale

0.501

High

824765

MLP2
Protein MLP2

1

20

Small-scale

0.501

High

829786

MAD1
Spindle assembly checkpoint component MAD1

1

20

Small-scale

0.501

High

850615

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

3

High-throughput

0.501

High

863201

SIP4
Protein SIP4

1

2

High-throughput

0.501

High

924170

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.501

High

926718

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

1

High-throughput

0.501

High

738600

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

3

High-throughput

0.489

High

824719

ESL1
EST/SMG-like protein 1

1

1

High-throughput

0.489

High

627776

HOP1
Meiosis-specific protein HOP1

1

0

High-throughput

0.480

High

836611

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.480

High

926710

YM04
Abasic site processing protein YMR114C

1

0

High-throughput

0.480

High

918115

CDH1
APC/C activator protein CDH1

1

20

Small-scale

0.479

High

926724

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.460

High

757821

YBF5
Deoxyribonuclease Tat-D

1

1

High-throughput

0.457

High

795485

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.457

High

806914

CRG1
Probable S-adenosylmethionine-dependent methyltransferase CRG1

1

1

High-throughput

0.457

High

917907

DUO1
DASH complex subunit DUO1

1

1

Small-scale

0.457

High

926712

AIM33
Uncharacterized oxidoreductase AIM33

1

7

High-throughput

0.457

High

926713

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

8

High-throughput

0.457

High

926714

RGC1
Regulator of the glycerol channel 1

1

3

High-throughput

0.457

High

926715

ACK1
Activator of C kinase protein 1

1

3

High-throughput

0.457

High

926722

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

4

High-throughput

0.457

High

926707

UBC7
Ubiquitin-conjugating enzyme E2 7

1

5

High-throughput

0.457

High

926709

MYO5
Myosin-5

1

18

High-throughput

0.457

High

527408

HSP72
Heat shock protein SSA2

1

20

High-throughput

0.445

High

545878

SSB1
Ribosome-associated molecular chaperone SSB1

1

20

High-throughput

0.445

High

590697

HSP26
Heat shock protein 26

1

2

High-throughput

0.445

High

819482

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

926717

NBA1
Protein NBA1

1

2

High-throughput

0.437

High

919097

DAM1
DASH complex subunit DAM1

4

0

Small-scale

0.357

High

776703

ASK1
DASH complex subunit ASK1

1

0

Small-scale

0.261

Low

781116

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.261

Low

926706

SPR6
Sporulation-specific protein

1

0

High-throughput

0.251

Low

926727

AIM44
Altered inheritance of mitochondria protein 44

1

0

High-throughput

0.249

Low

924474

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025