Protein: KNL1
Outer kinetochore KNL1 complex subunit SPC105 (105 kDa spindle pole component protein) (Spindle pole body component SPC105)

Gene: KNL1, SPC105
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: P53148

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0007094 - mitotic spindle assembly checkpoint signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

826678

DSN1
Kinetochore-associated protein DSN1

20

0

Small-scale

0.731

High

917730

ZWINT
Outer kinetochore KNL1 complex subunit KRE28

6

0

Small-scale

0.704

High

814080

MTW1
Kinetochore-associated protein MTW1

3

1

Small-scale

0.681

High

917731

SPC24
Kinetochore protein SPC24

5

0

Small-scale

0.676

High

917726

MPS1
Serine/threonine-protein kinase MPS1

4

0

Small-scale

0.667

High

755271

NUF2
Kinetochore protein NUF2

3

1

Small-scale

0.658

High

850686

CENPT
Inner kinetochore subunit CNN1

3

0

Small-scale

0.639

High

824854

NDC80
Kinetochore protein NDC80

2

1

Small-scale

0.635

High

817010

SPC25
Kinetochore protein SPC25

3

0

Small-scale

0.633

High

917722

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

High-throughput

0.631

High

866047

NNF1
Kinetochore-associated protein NNF1

3

0

High-throughput

0.627

High

797895

CENPU
Inner kinetochore subunit AME1

3

0

Small-scale

0.614

High

917743

NSL1
Kinetochore-associated protein NSL1

2

0

Small-scale

0.598

High

917742

SLK19
Kinetochore protein SLK19

2

0

High-throughput

0.576

High

782585

DAD2
DASH complex subunit DAD2

1

0

High-throughput

0.493

High

917733

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.493

High

524619

HSP71
Heat shock protein SSA1

1

0

Small-scale

0.480

High

438321

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.460

High

555266

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.460

High

639504

RE107
Recombination protein 107

1

0

High-throughput

0.460

High

646064

KIN3
Serine/threonine-protein kinase KIN3

1

0

High-throughput

0.460

High

665839

KPC1
Protein kinase C-like 1

1

0

High-throughput

0.460

High

735395

MCM10
Minichromosome maintenance protein 10

1

0

High-throughput

0.460

High

760555

SCD5
Protein SCD5

1

0

High-throughput

0.460

High

781575

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.460

High

837282

REF2
RNA end formation protein 2

1

0

High-throughput

0.460

High

849697

FMP32
Protein FMP32, mitochondrial

1

0

High-throughput

0.460

High

917725

IPI3
Pre-rRNA-processing protein IPI3

1

0

High-throughput

0.460

High

917727

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.460

High

917734

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.460

High

917735

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

917736

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.460

High

917740

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.460

High

917745

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.460

High

686920

BUB3
Spindle assembly checkpoint protein BUB3

1

0

Small-scale

0.458

High

707701

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

763748

CENPC
Inner kinetochore subunit MIF2

1

0

Small-scale

0.458

High

795751

STU1
Protein STU1

1

0

Small-scale

0.458

High

829782

MAD1
Spindle assembly checkpoint component MAD1

1

0

Small-scale

0.458

High

835512

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

1

0

Small-scale

0.458

High

917724

YBP2
YAP1-binding protein 2

1

0

Small-scale

0.458

High

917728

FIN1
Filament protein FIN1

1

0

Small-scale

0.458

High

917737

CENPO
Inner kinetochore subunit MCM21

1

0

Small-scale

0.458

High

917741

SGO1
Shugoshin

1

0

High-throughput

0.458

High

917744

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

545636

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

742023

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

819318

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

806045

KEL1
Kelch repeat-containing protein 1

1

1

High-throughput

0.439

High

893104

KEL2
Kelch repeat-containing protein 2

1

1

High-throughput

0.439

High

574907

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.438

High

917739

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

Small-scale

0.437

High

736023

SP110
Spindle pole body component 110

1

0

Small-scale

0.426

High

917746

CENPI
Inner kinetochore subunit CTF3

1

0

High-throughput

0.426

High

779560

LHS1
Heat shock protein 70 homolog LHS1

1

1

High-throughput

0.407

High

779779

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.269

Low

809204

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.269

Low

154363

YO304
Uncharacterized protein YOR304C-A

1

0

High-throughput

0.251

Low

758122

CASP
Protein CASP

1

0

High-throughput

0.251

Low

776448

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

High-throughput

0.251

Low

776760

YKF0
Uncharacterized protein YKL050C

1

0

High-throughput

0.251

Low

782942

JNM1
Nuclear migration protein JNM1

1

0

High-throughput

0.251

Low

796339

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

806439

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.251

Low

815037

SNF7
Vacuolar-sorting protein SNF7

1

0

High-throughput

0.251

Low

816694

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.251

Low

817743

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.251

Low

836303

BNI1
Protein BNI1

1

0

High-throughput

0.251

Low

864784

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.251

Low

917256

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.251

Low

917723

KXD1
Biogenesis of lysosome-related organelles complex 1 subunit KXD1

1

0

High-throughput

0.251

Low

917729

SNX41
Sorting nexin-41

1

0

High-throughput

0.251

Low

917732

IVY1
Protein IVY1

1

0

High-throughput

0.251

Low

917747

HPH1
Protein HPH1

1

0

High-throughput

0.251

Low

917738

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025