Protein: METK
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)

Gene: METK
Organism: Escherichia coli K-12
Interactions: 46
UniProt ID: P0A817

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006556 - S-adenosylmethionine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

494730

METK
S-adenosylmethionine synthase

2

15

Small-scale

0.768

High

489498

CH60
Chaperonin GroEL

2

0

Small-scale

0.758

High

490294

CLPX
ATP-dependent Clp protease ATP-binding subunit ClpX

2

1

High-throughput

0.588

High

490329

HSLU
ATP-dependent protease ATPase subunit HslU

2

1

High-throughput

0.588

High

494732

MREB
Cell shape-determining protein MreB

2

7

High-throughput

0.588

High

365864

DPO1
DNA polymerase I

2

0

High-throughput

0.563

High

490633

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

2

0

High-throughput

0.563

High

492281

RECA
Protein RecA

2

0

High-throughput

0.563

High

494733

PSTB
Phosphate import ATP-binding protein PstB

2

0

High-throughput

0.563

High

494736

GYRA
DNA gyrase subunit A

2

0

High-throughput

0.563

High

494737

GYRB
DNA gyrase subunit B

2

0

High-throughput

0.563

High

494738

SRP54
Signal recognition particle protein

2

0

High-throughput

0.563

High

494739

IBPA
Small heat shock protein IbpA

2

0

High-throughput

0.563

High

494742

SECA
Protein translocase subunit SecA

2

0

High-throughput

0.563

High

491588

KPRS
Ribose-phosphate pyrophosphokinase

1

1

High-throughput

0.536

High

494743

PHNN
Ribose 1,5-bisphosphate phosphokinase PhnN

1

0

High-throughput

0.513

High

494744

NADE
NH(3)-dependent NAD(+) synthetase

1

0

High-throughput

0.513

High

494752

SPEB
Agmatinase

1

0

High-throughput

0.513

High

473256

DNAJ
Chaperone protein DnaJ

1

4

High-throughput

0.484

High

491011

DNAK
Chaperone protein DnaK

1

2

High-throughput

0.484

High

494740

EFTU1
Elongation factor Tu 1

1

1

High-throughput

0.484

High

368951

SYGA
Glycine--tRNA ligase alpha subunit

1

0

High-throughput

0.464

High

421104

PNP
Polyribonucleotide nucleotidyltransferase

1

0

High-throughput

0.464

High

450004

MALT
HTH-type transcriptional regulator MalT

1

0

High-throughput

0.464

High

480533

GRPE
Protein GrpE

1

0

High-throughput

0.464

High

490245

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.464

High

491538

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

494749

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.464

High

437527

TSAD
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

490476

HSCB
Co-chaperone protein HscB

1

0

High-throughput

0.458

High

494755

LOLD
Lipoprotein-releasing system ATP-binding protein LolD

1

0

High-throughput

0.458

High

494756

DXS
1-deoxy-D-xylulose-5-phosphate synthase

1

0

High-throughput

0.458

High

494751

FLII
Flagellum-specific ATP synthase

1

1

High-throughput

0.457

High

494748

CBPA
Curved DNA-binding protein

1

1

High-throughput

0.442

High

456985

CHEA
Chemotaxis protein CheA

1

0

High-throughput

0.438

High

494731

TIG
Trigger factor

1

0

High-throughput

0.438

High

494735

FLIT
Flagellar protein FliT

1

0

High-throughput

0.438

High

494754

FLGF
Flagellar basal-body rod protein FlgF

1

1

High-throughput

0.417

High

494741

EFTU2
Elongation factor Tu 2

1

1

High-throughput

0.407

High

494734

FDNH
Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit

2

0

High-throughput

0.318

High

494745

YBFC
Uncharacterized protein YbfC

1

0

High-throughput

0.279

Low

494750

DEGQ
Periplasmic pH-dependent serine endoprotease DegQ

1

0

High-throughput

0.279

Low

494747

NUOCD
NADH-quinone oxidoreductase subunit C/D

1

0

High-throughput

0.249

Low

494753

YODC
Uncharacterized protein YodC

1

0

High-throughput

0.249

Low

494746

FLIR
Flagellar biosynthetic protein FliR

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025