Protein: DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)

Gene: DPH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 44
UniProt ID: P40487

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0017183 - protein histidyl modification to diphthamide
GO:0032991 - protein-containing complex
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690369

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

8

6

Small-scale

0.973

High

687397

EF2
Elongation factor 2

3

1

High-throughput

0.765

High

774561

DPH3
Diphthamide biosynthesis protein 3

8

2

Small-scale

0.745

High

543873

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.588

High

491451

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

511584

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.552

High

768611

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

606207

TRX1
Thioredoxin-1

1

2

High-throughput

0.515

High

456704

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

341811

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.493

High

389929

VDAC1
Mitochondrial outer membrane protein porin 1

1

0

High-throughput

0.493

High

423616

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.493

High

485749

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.493

High

698351

ELM1
Serine/threonine-protein kinase ELM1

1

0

High-throughput

0.493

High

759366

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

774553

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.493

High

439662

SPS1
Sporulation-specific protein 1

1

0

High-throughput

0.480

High

662429

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

761451

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

1

High-throughput

0.470

High

774552

DPH4
Diphthamide biosynthesis protein 4

1

1

High-throughput

0.457

High

478256

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

494150

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

560686

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.445

High

628987

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.445

High

694840

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

766046

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.445

High

774554

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.445

High

774557

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

11

High-throughput

0.445

High

759301

MET30
F-box protein MET30

1

0

High-throughput

0.438

High

774556

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

0

High-throughput

0.438

High

368129

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

554665

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

680768

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

688274

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.426

High

774559

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.426

High

772554

JEM1
DnaJ-like chaperone JEM1

1

3

High-throughput

0.407

High

774551

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

760749

TCPG
T-complex protein 1 subunit gamma

2

0

High-throughput

0.298

High

774558

CORO
Coronin-like protein

1

0

High-throughput

0.269

Low

774560

ZEO1
Protein ZEO1

1

0

High-throughput

0.269

Low

774555

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

429714

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.232

Low

560993

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low

588106

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024