Protein: MEC3
DNA damage checkpoint control protein MEC3

Gene: MEC3
Organism: Saccharomyces cerevisiae S288C
Interactions: 47
UniProt ID: Q02574

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000722 - telomere maintenance via recombination
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

874367

RAD17
DNA damage checkpoint control protein RAD17

16

0

Small-scale

0.935

High

1037854

DDC1
DNA damage checkpoint protein 1

8

0

Small-scale

0.722

High

805569

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

2

0

Small-scale

0.617

High

1037849

ATG16
Autophagy protein 16

2

0

High-throughput

0.594

High

735404

MCM10
Minichromosome maintenance protein 10

2

0

Small-scale

0.588

High

744620

TFB1
General transcription and DNA repair factor IIH subunit TFB1

2

0

High-throughput

0.582

High

744213

RAD24
Checkpoint protein RAD24

2

0

Small-scale

0.569

High

807714

REV7
DNA polymerase zeta processivity subunit

1

0

Small-scale

0.561

High

545966

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

1037852

RIX7
Ribosome biogenesis ATPase RIX7

1

0

High-throughput

0.518

High

917750

XRCC4
Non-homologous end-joining factor LIF1

1

0

High-throughput

0.513

High

602140

SPO12
Sporulation-specific protein 12

1

0

Small-scale

0.486

High

408341

GAL1
Galactokinase

1

0

High-throughput

0.479

High

597250

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.479

High

676279

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.479

High

814740

EXO1
Exodeoxyribonuclease 1

1

0

Small-scale

0.460

High

603098

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

726051

FUN30
ATP-dependent helicase FUN30

1

0

Small-scale

0.458

High

1037851

CST9
Chromosome stability protein 9

1

0

Small-scale

0.458

High

1037853

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.457

High

1037855

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

1

High-throughput

0.457

High

524897

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527474

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

742217

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

742928

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.445

High

819565

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

1037848

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

High-throughput

0.438

High

727261

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

1037850

LIPB
Octanoyltransferase, mitochondrial

2

0

High-throughput

0.295

High

758496

YKK7
Uncharacterized oxidoreductase YKL107W

1

0

High-throughput

0.282

High

763163

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.282

High

1037856

YL125
Putative uncharacterized protein YLR125W

1

0

High-throughput

0.282

High

449170

CALM
Calmodulin

1

0

High-throughput

0.269

Low

623931

MYO2
Myosin-2

1

0

High-throughput

0.269

Low

917626

MLC1
Myosin light chain 1

1

0

High-throughput

0.269

Low

571321

RED1
Protein RED1

1

0

Small-scale

0.265

Low

368734

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

425143

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

450634

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

531388

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.261

Low

555136

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

592448

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.261

Low

1037857

HSP42
Heat shock protein 42

1

0

High-throughput

0.261

Low

864271

ALY2
Arrestin-related trafficking adapter 3

1

0

High-throughput

0.238

Low

577202

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

811142

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

863700

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025