Protein: FAS1
Fatty acid synthase subunit beta (EC 2.3.1.86) [Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9); [Acyl-carrier-protein] acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] malonyltransferase (EC 2.3.1.39); S-acyl fatty acid synthase thioesterase (EC 3.1.2.14)]

Gene: FAS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 204
UniProt ID: P07149

Gene Ontology (top 5):
GO:0004312 - fatty acid synthase activity
GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity
GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity
GO:0004318 - enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0004321 - fatty-acyl-CoA synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

450518

FAS2
Fatty acid synthase subunit alpha

8

7

Small-scale

0.973

High

450573

ATG8
Autophagy-related protein 8

3

7

Small-scale

0.640

High

450486

FAS1
Fatty acid synthase subunit beta

1

10

High-throughput

0.618

High

450608

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

0

High-throughput

0.613

High

450502

SSBP1
Single-stranded nucleic acid-binding protein

2

0

High-throughput

0.592

High

450652

TRM3
tRNA

2

0

High-throughput

0.585

High

450548

HOG1
Mitogen-activated protein kinase HOG1

2

3

High-throughput

0.584

High

450527

SIS1
Protein SIS1

2

0

High-throughput

0.576

High

399325

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

2

High-throughput

0.536

High

450494

TBA3
Tubulin alpha-3 chain

1

3

High-throughput

0.536

High

450525

MPCP
Mitochondrial phosphate carrier protein

1

2

High-throughput

0.536

High

450568

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.536

High

450624

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

450631

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

450639

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.536

High

450601

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

450487

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

450505

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.513

High

450577

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

0

High-throughput

0.513

High

450665

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.513

High

450508

YPK1
Serine/threonine-protein kinase YPK1

1

2

High-throughput

0.501

High

448598

SNF1
Carbon catabolite-derepressing protein kinase

1

1

High-throughput

0.500

High

450512

YAK1
Dual specificity protein kinase YAK1

1

2

High-throughput

0.500

High

450514

ABP1
Actin-binding protein

1

2

High-throughput

0.500

High

450666

DUF1
DUB-associated factor 1

1

4

High-throughput

0.500

High

450560

SLA2
Protein SLA2

1

1

High-throughput

0.489

High

450522

RFA1
Replication factor A protein 1

1

3

Small-scale

0.481

High

416775

DNLI1
DNA ligase 1

1

0

High-throughput

0.479

High

449042

CALM
Calmodulin

1

0

High-throughput

0.479

High

450509

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.479

High

450547

CDC11
Cell division control protein 11

1

0

High-throughput

0.479

High

450621

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.479

High

450654

RBX1
RING-box protein HRT1

1

0

High-throughput

0.479

High

392002

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

438558

SC160
Protein SCP160

1

3

High-throughput

0.479

High

441601

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

450489

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

450492

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.479

High

450504

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.479

High

450507

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.479

High

450513

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

450519

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

450520

HSP74
Heat shock protein SSA4

1

6

High-throughput

0.479

High

450523

KCC2
Calcium/calmodulin-dependent protein kinase II

1

2

High-throughput

0.479

High

450530

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

450533

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

450542

BMH1
Protein BMH1

1

4

Small-scale

0.479

High

450554

HFA1
Acetyl-CoA carboxylase, mitochondrial

1

2

High-throughput

0.479

High

450556

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

450563

BMH2
Protein BMH2

1

4

Small-scale

0.479

High

450564

SQT1
Ribosome assembly protein SQT1

1

2

High-throughput

0.479

High

450571

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

450578

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

450581

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

450589

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

450590

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

450598

TM108
Protein TMA108

1

2

High-throughput

0.479

High

450617

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

450629

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

450632

MDM1
Structural protein MDM1

1

1

Small-scale

0.479

High

450638

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

450643

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

450658

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

149486

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383414

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

401815

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

409838

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

427070

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.458

High

430736

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

Small-scale

0.458

High

433344

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

434691

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435667

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

450488

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

450496

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

450497

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

450499

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

450500

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

450501

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

450510

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

450511

DPOZ
DNA polymerase zeta catalytic subunit

1

0

Small-scale

0.458

High

450536

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

450537

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

450549

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

450557

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

450558

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

450561

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

450565

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

450566

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

450574

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

450575

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

450576

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

450582

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

450586

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

450593

ARB1
ABC transporter ATP-binding protein ARB1

1

0

Small-scale

0.458

High

450603

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

450606

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

450607

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

450611

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

450625

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.458

High

450627

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

450630

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.458

High

450633

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

450655

SGO1
Shugoshin

1

0

High-throughput

0.458

High

450656

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

450660

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

450664

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

450521

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.457

High

450562

DCA13
Protein SOF1

1

2

High-throughput

0.457

High

450604

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.457

High

368299

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

1

High-throughput

0.445

High

416985

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.445

High

450495

CDC16
Anaphase-promoting complex subunit CDC16

1

1

High-throughput

0.445

High

450498

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

5

High-throughput

0.445

High

450503

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

450506

CDC24
Cell division control protein 24

1

2

High-throughput

0.445

High

450538

KCC1
Calcium/calmodulin-dependent protein kinase I

1

2

High-throughput

0.445

High

450546

APE2
Aminopeptidase 2, mitochondrial

1

2

High-throughput

0.445

High

450551

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.445

High

450552

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

450555

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.445

High

450579

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

450594

PIC2
Mitochondrial phosphate carrier protein 2

1

2

High-throughput

0.445

High

450600

SCC3
Cohesin subunit SCC3

1

1

High-throughput

0.445

High

450620

RBG2
Ribosome-interacting GTPase 2

1

1

High-throughput

0.445

High

450650

RHC31
DNA damage tolerance protein RHC31

1

1

High-throughput

0.445

High

450641

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

450662

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

450663

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

438234

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.426

High

450490

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.426

High

450493

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.426

High

450515

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

450516

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

450524

MRS4
Mitochondrial RNA-splicing protein MRS4

1

0

High-throughput

0.426

High

450526

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.426

High

450528

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.426

High

450529

LSB5
LAS seventeen-binding protein 5

1

0

High-throughput

0.426

High

450535

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

450539

BUD14
Bud site selection protein 14

1

0

High-throughput

0.426

High

450544

RENT1
ATP-dependent helicase NAM7

1

0

High-throughput

0.426

High

450545

BTAF1
TATA-binding protein-associated factor MOT1

1

0

High-throughput

0.426

High

450559

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.426

High

450570

PXL1
Paxillin-like protein 1

1

0

High-throughput

0.426

High

450572

SEA4
SEH-associated protein 4

1

0

High-throughput

0.426

High

450584

GGA2
ADP-ribosylation factor-binding protein GGA2

1

0

High-throughput

0.426

High

450591

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.426

High

450599

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

450614

SOL1
6-phosphogluconolactonase-like protein 1

1

0

High-throughput

0.426

High

450615

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.426

High

450635

RPM2
Ribonuclease P protein component, mitochondrial

1

0

High-throughput

0.426

High

450637

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.426

High

450651

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.426

High

450657

GPN2
GPN-loop GTPase 2

1

0

High-throughput

0.426

High

450580

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.407

High

450595

UTP7
U3 small nucleolar RNA-associated protein 7

1

3

High-throughput

0.407

High

450613

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.407

High

450636

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.407

High

450642

PDR15
ATP-dependent permease PDR15

1

1

High-throughput

0.407

High

450531

RAD51
DNA repair protein RAD51

1

0

High-throughput

0.279

Low

450543

SEC1
Protein transport protein SEC1

1

0

High-throughput

0.279

Low

450587

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.279

Low

450491

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

450534

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

450553

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.261

Low

450585

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.261

Low

450616

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.261

Low

450634

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.261

Low

450644

PEX12
Peroxisome assembly protein 12

1

0

High-throughput

0.261

Low

450645

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.261

Low

450653

NOP6
Nucleolar protein 6

1

0

High-throughput

0.261

Low

450569

MID2
Cell wall integrity sensor MID2

1

0

Small-scale

0.251

Low

450628

SLG1
Protein SLG1

1

0

Small-scale

0.251

Low

450532

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

450541

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

450567

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

450588

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

450602

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

450605

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

450610

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

450612

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

450619

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

450646

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

450649

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

450659

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

450667

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

150246

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.232

Low

450517

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low

450540

FUN19
SWIRM domain-containing protein FUN19

1

0

High-throughput

0.232

Low

450550

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.232

Low

450583

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.232

Low

450592

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.232

Low

450596

GET2
Golgi to ER traffic protein 2

1

0

High-throughput

0.232

Low

450597

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low

450609

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.232

Low

450618

NNF2
Protein NNF2

1

0

High-throughput

0.232

Low

450622

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low

450623

DBP6
ATP-dependent RNA helicase DBP6

1

0

High-throughput

0.232

Low

450626

SFB2
SED5-binding protein 2

1

0

High-throughput

0.232

Low

450640

HAS1
ATP-dependent RNA helicase HAS1

1

0

High-throughput

0.232

Low

450647

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

450648

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.232

Low

450661

MAM3
Protein MAM3

1

0

High-throughput

0.232

Low

450668

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025