Protein: OTC
Ornithine carbamoyltransferase (EC 2.1.3.3) (Ornithine transcarbamylase) (OTCase)

Gene: OTC, ARG3
Organism: Saccharomyces cerevisiae S288C
Interactions: 72
UniProt ID: P05150

Gene Ontology (top 5):
GO:0004585 - ornithine carbamoyltransferase activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006526 - L-arginine biosynthetic process
GO:0016597 - amino acid binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

425133

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

366627

ARGI
Arginase

1

1

Small-scale

0.582

High

425093

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.500

High

425107

RFA1
Replication factor A protein 1

1

2

High-throughput

0.500

High

425110

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

6

High-throughput

0.500

High

425127

MLH1
DNA mismatch repair protein MLH1

1

1

High-throughput

0.500

High

425145

POLH
DNA polymerase eta

1

1

High-throughput

0.500

High

425154

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

3

High-throughput

0.500

High

425159

SMC6
Structural maintenance of chromosomes protein 6

1

3

High-throughput

0.500

High

425103

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.493

High

425099

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.479

High

425115

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.479

High

425124

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.479

High

425137

UBC13
Ubiquitin-conjugating enzyme E2 13

1

0

High-throughput

0.479

High

425138

MMS2
Ubiquitin-conjugating enzyme variant MMS2

1

0

High-throughput

0.479

High

425108

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

425126

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

425090

CDC7
Cell division control protein 7

1

7

High-throughput

0.464

High

425094

RAD2
DNA repair protein RAD2

1

2

High-throughput

0.457

High

425095

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.457

High

425096

PBS2
MAP kinase kinase PBS2

1

11

High-throughput

0.457

High

425100

SRS2
ATP-dependent DNA helicase SRS2

1

1

High-throughput

0.457

High

425104

PWP1
Periodic tryptophan protein 1

1

4

High-throughput

0.457

High

425106

DBF2
Cell cycle protein kinase DBF2

1

6

High-throughput

0.457

High

425109

RAD57
DNA repair protein RAD57

1

1

High-throughput

0.457

High

425112

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

1

High-throughput

0.457

High

425113

BUB3
Spindle assembly checkpoint protein BUB3

1

3

High-throughput

0.457

High

425114

PSO2
DNA cross-link repair protein PSO2/SNM1

1

1

High-throughput

0.457

High

425118

MKK1
MAP kinase kinase MKK1/SSP32

1

9

High-throughput

0.457

High

425120

PP2C3
Protein phosphatase 2C homolog 3

1

2

High-throughput

0.457

High

425130

RFC2
Replication factor C subunit 2

1

2

High-throughput

0.457

High

425131

PRK1
Actin-regulating kinase PRK1

1

2

High-throughput

0.457

High

425134

BBC1
Myosin tail region-interacting protein MTI1

1

3

High-throughput

0.457

High

425136

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

7

High-throughput

0.457

High

425142

FAP1
FKBP12-associated protein 1

1

1

High-throughput

0.457

High

425144

WDR59
Maintenance of telomere capping protein 5

1

6

High-throughput

0.457

High

425147

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.457

High

425148

SEC13
Protein transport protein SEC13

1

3

High-throughput

0.457

High

425149

ITT1
E3 ubiquitin-protein ligase ITT1

1

2

High-throughput

0.457

High

425151

FAR10
Factor arrest protein 10

1

1

High-throughput

0.457

High

425155

PIB1
E3 ubiquitin-protein ligase PIB1

1

1

High-throughput

0.457

High

425157

PSH1
RING finger protein PSH1

1

2

High-throughput

0.457

High

425158

RAD59
DNA repair protein RAD59

1

2

High-throughput

0.457

High

391962

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

425097

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

425116

HS104
Heat shock protein 104

1

2

High-throughput

0.445

High

425129

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

425153

NCS1
Calcium-binding protein NCS-1

1

0

High-throughput

0.438

High

425119

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.437

High

425125

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.437

High

425140

CWC24
Pre-mRNA-splicing factor CWC24

1

1

High-throughput

0.437

High

425139

YG5B
Uncharacterized RNA-binding protein YGR250C

1

0

High-throughput

0.269

Low

425091

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

425092

RAD7
DNA repair protein RAD7

1

0

High-throughput

0.261

Low

425098

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

425101

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.261

Low

425102

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.261

Low

425105

MAG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.261

Low

425111

PWP2
Periodic tryptophan protein 2

1

0

High-throughput

0.261

Low

425117

ARP2
Actin-related protein 2

1

0

High-throughput

0.261

Low

425121

SLD2
DNA replication regulator SLD2

1

0

High-throughput

0.261

Low

425122

MMS4
Crossover junction endonuclease MMS4

1

0

High-throughput

0.261

Low

425123

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.261

Low

425128

FKHL1
Pre-rRNA-processing protein FHL1

1

0

High-throughput

0.261

Low

425132

SKP2
F-box protein SKP2

1

0

High-throughput

0.261

Low

425141

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.261

Low

425143

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.261

Low

425146

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.261

Low

425150

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.261

Low

425156

DDC1
DNA damage checkpoint protein 1

1

0

High-throughput

0.261

Low

425152

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

425135

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025