Protein: EST1
Telomere elongation protein EST1 (Ever shorter telomeres protein 1)

Gene: EST1
Organism: Saccharomyces cerevisiae S288C
Interactions: 148
UniProt ID: P17214

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0003697 - single-stranded DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

603028

CDC13
Cell division control protein 13

7

0

Small-scale

0.716

High

603112

TERT
Telomerase reverse transcriptase

7

0

Small-scale

0.712

High

603106

KU80
ATP-dependent DNA helicase II subunit 2

3

1

Small-scale

0.640

High

603099

EST3
Telomere replication protein EST3

3

0

Small-scale

0.619

High

603076

MPS3
Spindle pole body assembly component MPS3

2

0

Small-scale

0.587

High

602999

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.586

High

603045

RPF2
Ribosome biogenesis protein RPF2

2

0

High-throughput

0.585

High

392182

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.571

High

603017

MAS5
Mitochondrial protein import protein MAS5

2

0

High-throughput

0.569

High

603085

POP6
Ribonucleases P/MRP protein subunit POP6

2

0

Small-scale

0.559

High

603124

RUXE
Small nuclear ribonucleoprotein E

2

0

Small-scale

0.559

High

603128

HSH49
Protein HSH49

1

1

High-throughput

0.536

High

584175

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

0

High-throughput

0.513

High

603005

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.513

High

603015

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

603038

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.513

High

603040

RRP1
Ribosomal RNA-processing protein 1

1

0

High-throughput

0.513

High

603043

DBP7
ATP-dependent RNA helicase DBP7

1

0

High-throughput

0.513

High

603068

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.513

High

603093

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.513

High

603105

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.513

High

603127

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.513

High

603072

ECO1
N-acetyltransferase ECO1

1

0

Small-scale

0.505

High

517882

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

603034

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.489

High

603041

SPT23
Protein SPT23

1

0

High-throughput

0.486

High

603082

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.486

High

603008

RFA1
Replication factor A protein 1

1

0

Small-scale

0.480

High

403340

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

603007

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

603020

BMH1
Protein BMH1

1

0

High-throughput

0.479

High

603050

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.479

High

590520

HSP26
Heat shock protein 26

1

1

High-throughput

0.479

High

603003

PSA7
Probable proteasome subunit alpha type-7

1

1

High-throughput

0.479

High

603004

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.479

High

603013

PSB6
Proteasome subunit beta type-6

1

1

High-throughput

0.479

High

603021

PSB5
Proteasome subunit beta type-5

1

1

High-throughput

0.479

High

603025

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.479

High

603026

HSP79
Heat shock protein homolog SSE2

1

1

High-throughput

0.479

High

603029

KU70
ATP-dependent DNA helicase II subunit 1

1

1

High-throughput

0.479

High

603030

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.479

High

603032

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.479

High

603033

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

High-throughput

0.479

High

603049

PSB1
Proteasome subunit beta type-1

1

1

High-throughput

0.479

High

603052

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

603057

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

1

High-throughput

0.479

High

603063

PRS4
26S proteasome regulatory subunit 4 homolog

1

1

High-throughput

0.479

High

603073

RRP41
Exosome complex component SKI6

1

1

High-throughput

0.479

High

603087

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

603089

PRS10
26S proteasome subunit RPT4

1

2

High-throughput

0.479

High

603109

RPN7
26S proteasome regulatory subunit RPN7

1

1

High-throughput

0.479

High

603129

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

1

High-throughput

0.479

High

150254

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

486014

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.458

High

518192

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.458

High

522974

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.458

High

550621

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.458

High

555224

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.458

High

584334

GCN2
eIF-2-alpha kinase GCN2

1

0

High-throughput

0.458

High

603012

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

603016

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.458

High

603018

SPB1
27S pre-rRNA

1

0

High-throughput

0.458

High

603019

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

603027

BRR2
Pre-mRNA-splicing helicase BRR2

1

0

High-throughput

0.458

High

603031

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

603035

NPL4
Nuclear protein localization protein 4

1

0

High-throughput

0.458

High

603036

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.458

High

603037

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.458

High

603039

HSL1
Probable serine/threonine-protein kinase HSL1

1

0

High-throughput

0.458

High

603044

SPO14
Phospholipase D1

1

0

High-throughput

0.458

High

603048

POP7
Ribonucleases P/MRP protein subunit POP7

1

0

High-throughput

0.458

High

603051

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

603053

CSK2C
Casein kinase II subunit beta'

1

0

High-throughput

0.458

High

603059

IMB4
Importin subunit beta-4

1

0

High-throughput

0.458

High

603060

RUXG
Small nuclear ribonucleoprotein G

1

0

High-throughput

0.458

High

603061

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.458

High

603062

PSA4
Proteasome subunit alpha type-4

1

0

High-throughput

0.458

High

603067

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

603069

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.458

High

603070

GAT1
Transcriptional regulatory protein GAT1

1

0

High-throughput

0.458

High

603071

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

603074

NMD5
Nonsense-mediated mRNA decay protein 5

1

0

High-throughput

0.458

High

603075

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.458

High

603077

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

603078

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

603079

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.458

High

603080

UFD1
Ubiquitin fusion degradation protein 1

1

0

High-throughput

0.458

High

603083

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

603084

SWC4
SWR1-complex protein 4

1

0

High-throughput

0.458

High

603086

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.458

High

603090

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.458

High

603092

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.458

High

603095

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

603096

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.458

High

603098

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.458

High

603100

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

603101

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.458

High

603103

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.458

High

603107

EUC1
Transcription factor-like protein EUC1

1

0

High-throughput

0.458

High

603108

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

603110

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.458

High

603111

LCB5
Sphingoid long chain base kinase 5

1

0

High-throughput

0.458

High

603113

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

603114

VPS74
Vacuolar protein sorting-associated protein 74

1

0

High-throughput

0.458

High

603120

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.458

High

603121

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

603023

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

2

High-throughput

0.437

High

603065

VTH1
VPS10 homolog 1

1

2

High-throughput

0.437

High

603066

EPS1
ER-retained PMA1-suppressing protein 1

1

1

High-throughput

0.437

High

603081

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.437

High

603091

YN94
Uncharacterized membrane glycoprotein YNR065C

1

2

High-throughput

0.437

High

603122

RPN5
26S proteasome regulatory subunit RPN5

1

1

High-throughput

0.437

High

603123

HSP42
Heat shock protein 42

1

1

High-throughput

0.437

High

603000

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.279

Low

603058

MRX1
MIOREX complex component 1

1

0

High-throughput

0.279

Low

603116

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.279

Low

603010

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.265

Low

603055

HPH2
Protein HPH2

1

0

High-throughput

0.265

Low

603102

YMD8
Putative nucleotide-sugar transporter YMD8

1

0

High-throughput

0.265

Low

394203

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

603001

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.261

Low

603006

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

444372

HIS7
Imidazoleglycerol-phosphate dehydratase

1

0

High-throughput

0.249

Low

569458

RM31
Large ribosomal subunit protein mL60

1

0

High-throughput

0.249

Low

585583

STI1
Heat shock protein STI1

1

0

High-throughput

0.249

Low

603002

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.249

Low

603009

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.249

Low

603011

RM25
Large ribosomal subunit protein mL59

1

0

High-throughput

0.249

Low

603022

RM09
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.249

Low

603024

RM41
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

603042

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.249

Low

603046

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.249

Low

603047

RM27
Large ribosomal subunit protein mL41

1

0

High-throughput

0.249

Low

603054

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.249

Low

603056

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.249

Low

603064

PDAT
Phospholipid:diacylglycerol acyltransferase

1

0

High-throughput

0.249

Low

603094

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.249

Low

603097

MLP1
Protein MLP1

1

0

High-throughput

0.249

Low

603104

UBX2
UBX domain-containing protein 2

1

0

High-throughput

0.249

Low

603115

TUS1
Rho1 guanine nucleotide exchange factor TUS1

1

0

High-throughput

0.249

Low

603117

GUAD
Probable guanine deaminase

1

0

High-throughput

0.249

Low

603118

ISA1
Iron-sulfur assembly protein 1

1

0

High-throughput

0.249

Low

603119

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.249

Low

603125

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.249

Low

603126

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.249

Low

603014

TSR4
20S rRNA accumulation protein 4

1

0

High-throughput

0.238

Low

603088

YG3R
Putative uncharacterized protein YGR160W

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025