Protein: SWC4
SWR1-complex protein 4 (ESA1-associated factor 2)

Gene: SWC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 71
UniProt ID: P53201

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000812 - Swr1 complex
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

918174

SWR1
Helicase SWR1

20

7

Small-scale

0.987

High

918166

ARP4
Actin-related protein 4

6

11

Small-scale

0.945

High

918175

EAF1
Chromatin modification-related protein EAF1

9

0

Small-scale

0.921

High

918164

ACT
Actin

3

6

Small-scale

0.839

High

849798

EPL1
Enhancer of polycomb-like protein 1

14

7

Small-scale

0.760

High

918182

ESA1
Histone acetyltransferase ESA1

13

7

Small-scale

0.757

High

805130

YNG2
Chromatin modification-related protein YNG2

7

5

Small-scale

0.749

High

918170

RUVB1
RuvB-like protein 1

8

9

Small-scale

0.747

High

918160

AF9
Protein AF-9 homolog

7

8

Small-scale

0.745

High

918188

H2AZ
Histone H2A.Z

7

3

Small-scale

0.742

High

918186

RUVB2
RuvB-like protein 2

5

9

Small-scale

0.716

High

918167

VPS72
Vacuolar protein sorting-associated protein 72

5

4

Small-scale

0.709

High

918185

EAF3
Chromatin modification-related protein EAF3

5

4

Small-scale

0.703

High

805200

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

4

4

Small-scale

0.699

High

816619

EAF5
Chromatin modification-related protein EAF5

5

0

Small-scale

0.690

High

798120

SWC5
SWR1-complex protein 5

5

0

Small-scale

0.684

High

865840

EAF6
Chromatin modification-related protein EAF6

5

0

Small-scale

0.684

High

918159

EAF7
Chromatin modification-related protein EAF7

5

0

Small-scale

0.684

High

777085

BDF1
Bromodomain-containing factor 1

4

3

Small-scale

0.676

High

725971

SWC3
SWR1-complex protein 3

4

0

Small-scale

0.661

High

918179

SWC7
SWR1-complex protein 7

4

0

Small-scale

0.658

High

918168

VPS71
Vacuolar protein sorting-associated protein 71

3

0

Small-scale

0.638

High

918187

ARP6
Actin-like protein ARP6

1

10

High-throughput

0.618

High

419467

H2A1
Histone H2A.1

2

1

Small-scale

0.584

High

918165

H3
Histone H3

2

3

High-throughput

0.571

High

918176

SP382
Pre-mRNA-splicing factor SPP382

2

0

High-throughput

0.551

High

754227

MSN4
Zinc finger protein MSN4

2

0

High-throughput

0.547

High

722116

XPO1
Exportin-1

1

2

High-throughput

0.536

High

918177

PIN3
[PSI+] inducibility protein 3

1

0

High-throughput

0.518

High

466796

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.513

High

918158

SWC4
SWR1-complex protein 4

1

1

Small-scale

0.479

High

918162

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

603084

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

647171

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

661546

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

707716

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

747958

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

763946

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

764125

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

808864

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

826683

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

918163

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

918171

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

918178

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

918181

SGO1
Shugoshin

1

0

High-throughput

0.458

High

918183

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

381182

H2B1
Histone H2B.1

1

4

High-throughput

0.445

High

382236

H4
Histone H4

1

1

High-throughput

0.445

High

524638

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527247

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

545662

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

676193

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

742038

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

819337

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

548917

SCH9
Serine/threonine-protein kinase SCH9

1

0

High-throughput

0.426

High

653879

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

804319

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

863059

GUF1
Translation factor GUF1, mitochondrial

1

0

High-throughput

0.426

High

844543

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

918172

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

740499

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.238

Low

753123

NIP80
Protein NIP100

1

0

High-throughput

0.238

Low

918161

CARME
Carnosine N-methyltransferase

1

0

High-throughput

0.238

Low

918184

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.238

Low

477598

MYO1
Myosin-1

1

0

High-throughput

0.232

Low

752538

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

912740

NU188
Nucleoporin NUP188

1

0

High-throughput

0.232

Low

918169

TR130
Trafficking protein particle complex II-specific subunit 130

1

0

High-throughput

0.232

Low

918173

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low

918180

YO075
Uncharacterized ABC transporter ATP-binding protein/permease YOL075C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025