Protein: SP382
Pre-mRNA-splicing factor SPP382 (CLF1 complex factor 8) (Nineteen complex-related protein 1) (NTC-related protein 1) (Suppressor of PRP38 protein 2)

Gene: SP382, SPP382
Organism: Saccharomyces cerevisiae S288C
Interactions: 159
UniProt ID: Q06411

Gene Ontology (top 5):
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000390 - spliceosomal complex disassembly
GO:0000781 - chromosome, telomeric region
GO:0003676 - nucleic acid binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

917486

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

15

0

Small-scale

0.936

High

744169

BRR2
Pre-mRNA-splicing helicase BRR2

3

0

High-throughput

0.816

High

914884

CWC23
Pre-mRNA-splicing factor CWC23

10

0

Small-scale

0.726

High

781589

NTR2
Pre-mRNA-splicing factor NTR2

9

0

Small-scale

0.726

High

1055008

CLF1
Pre-mRNA-splicing factor CLF1

4

3

Small-scale

0.699

High

751793

PRP8
Pre-mRNA-splicing factor 8

4

0

Small-scale

0.667

High

917753

XRCC4
Non-homologous end-joining factor LIF1

4

0

Small-scale

0.659

High

817167

RSMB
Small nuclear ribonucleoprotein-associated protein B

3

0

High-throughput

0.638

High

933145

RUXF
Small nuclear ribonucleoprotein F

3

0

High-throughput

0.629

High

1044947

SYF1
Pre-mRNA-splicing factor SYF1

2

3

Small-scale

0.628

High

702285

YJU2
Splicing factor YJU2

3

0

Small-scale

0.623

High

1054992

SWC7
SWR1-complex protein 7

3

0

High-throughput

0.612

High

1043508

CEF1
Pre-mRNA-splicing factor CEF1

2

0

Small-scale

0.606

High

780227

SN114
Pre-mRNA-splicing factor SNU114

2

0

High-throughput

0.602

High

1055011

PRP46
Pre-mRNA-splicing factor PRP46

2

0

High-throughput

0.602

High

700153

PRP45
Pre-mRNA-processing protein 45

2

0

Small-scale

0.596

High

1054990

YL419
Putative ATP-dependent RNA helicase YLR419W

1

1

High-throughput

0.590

High

684921

DAL80
Nitrogen regulatory protein DAL80

2

1

High-throughput

0.590

High

844489

GZF3
Protein GZF3

2

1

High-throughput

0.590

High

605419

RTPT
Small ribosomal subunit protein mS26

2

0

High-throughput

0.582

High

919107

DAM1
DASH complex subunit DAM1

2

0

High-throughput

0.582

High

638086

ISY1
Pre-mRNA-splicing factor ISY1

2

0

Small-scale

0.576

High

739207

PRP19
Pre-mRNA-processing factor 19

2

0

Small-scale

0.576

High

811239

PCF11
Protein PCF11

2

0

High-throughput

0.565

High

1054988

SP382
Pre-mRNA-splicing factor SPP382

2

0

Small-scale

0.565

High

820843

RUXG
Small nuclear ribonucleoprotein G

2

0

High-throughput

0.563

High

682392

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.560

High

1054999

ULS1
ATP-dependent helicase ULS1

1

0

High-throughput

0.560

High

918176

SWC4
SWR1-complex protein 4

2

0

High-throughput

0.551

High

924134

SQS1
Protein SQS1

2

0

Small-scale

0.551

High

1055009

IES3
Ino eighty subunit 3

2

0

High-throughput

0.541

High

525244

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.536

High

546386

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

1034910

SKO1
CRE-binding bZIP protein SKO1

1

0

High-throughput

0.518

High

1044567

CTK1
CTD kinase subunit alpha

1

0

High-throughput

0.518

High

1054993

BRE1
E3 ubiquitin-protein ligase BRE1

1

0

High-throughput

0.518

High

531899

RL4A
Large ribosomal subunit protein uL4A

1

0

Small-scale

0.513

High

781265

RL14A
Large ribosomal subunit protein eL14A

1

0

Small-scale

0.513

High

796467

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.513

High

847836

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.513

High

863754

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.513

High

919223

SYF2
Pre-mRNA-splicing factor SYF2

1

0

Small-scale

0.513

High

1050170

RRP5
rRNA biogenesis protein RRP5

1

0

Small-scale

0.513

High

1055000

SNX3
Sorting nexin-3

1

1

Small-scale

0.494

High

1055002

RKM1
Ribosomal lysine N-methyltransferase 1

1

0

High-throughput

0.493

High

699377

ERV1
Mitochondrial FAD-linked sulfhydryl oxidase ERV1

1

0

High-throughput

0.486

High

919335

BTN2
Protein BTN2

1

0

High-throughput

0.486

High

1036346

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.486

High

1054968

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.486

High

397500

REP2
Partitioning protein REP2

1

0

Small-scale

0.479

High

747760

SMC1
Structural maintenance of chromosomes protein 1

1

0

High-throughput

0.460

High

792486

CDC27
Anaphase-promoting complex subunit CDC27

1

0

High-throughput

0.460

High

999593

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.460

High

1038163

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

1053917

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.460

High

1054996

SDO1
Ribosome maturation protein SDO1

1

0

Small-scale

0.460

High

708261

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

1055001

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.458

High

1055003

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.458

High

1055006

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

625050

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.457

High

753146

NIP80
Protein NIP100

1

1

High-throughput

0.457

High

802137

STB5
Protein STB5

1

1

High-throughput

0.457

High

871511

ASK10
Activator of SKN7 protein 10

1

1

High-throughput

0.457

High

1049128

SNO4
Probable glutathione-independent glyoxalase SNO4

1

1

High-throughput

0.457

High

1053629

RGC1
Regulator of the glycerol channel 1

1

1

High-throughput

0.457

High

1055004

HSP32
Probable glutathione-independent glyoxalase HSP32

1

1

High-throughput

0.457

High

527755

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

742467

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

742955

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.445

High

819874

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

886209

NU145
Nucleoporin NUP145

1

1

High-throughput

0.445

High

554767

REV1
DNA repair protein REV1

1

0

High-throughput

0.438

High

624469

RDS2
Regulator of drug sensitivity 2

1

0

High-throughput

0.438

High

646620

TRX1
Thioredoxin-1

1

0

High-throughput

0.438

High

673753

SSK22
Serine/threonine-protein kinase SSK22

1

0

High-throughput

0.438

High

678745

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

High-throughput

0.438

High

678899

CSM1
Monopolin complex subunit CSM1

1

0

High-throughput

0.438

High

679004

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.438

High

694650

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.438

High

727687

TPS2
Trehalose-phosphatase

1

0

High-throughput

0.438

High

735410

MCM10
Minichromosome maintenance protein 10

1

0

High-throughput

0.438

High

738013

MEI5
Meiosis protein 5

1

0

High-throughput

0.438

High

745502

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.438

High

747170

RT04
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.438

High

750308

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.438

High

763198

TOM20
Mitochondrial import receptor subunit TOM20

1

0

High-throughput

0.438

High

792967

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.438

High

797279

YBY8
Uncharacterized protein YBR138C

1

0

High-throughput

0.438

High

798186

RMD9L
RNA-binding protein RMD9-like, mitochondrial

1

0

High-throughput

0.438

High

803779

PIH1
Protein interacting with Hsp90 1

1

0

High-throughput

0.438

High

804006

RSC30
Chromatin structure-remodeling complex protein RSC30

1

0

High-throughput

0.438

High

805439

BZZ1
Protein BZZ1

1

0

High-throughput

0.438

High

812870

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

High-throughput

0.438

High

813350

MBP1
Transcription factor MBP1

1

0

High-throughput

0.438

High

814093

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.438

High

816113

HPA3
D-amino-acid N-acetyltransferase HPA3

1

0

High-throughput

0.438

High

817029

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.438

High

818349

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.438

High

820281

WRIP1
DNA-dependent ATPase MGS1

1

0

High-throughput

0.438

High

823045

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.438

High

824796

MLP2
Protein MLP2

1

0

High-throughput

0.438

High

825633

AIR1
Protein AIR1

1

0

High-throughput

0.438

High

825725

CSN11
Cop9 signalosome complex subunit 11

1

0

High-throughput

0.438

High

826857

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.438

High

849812

EPL1
Enhancer of polycomb-like protein 1

1

0

High-throughput

0.438

High

858421

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.438

High

864332

NET1
Nucleolar protein NET1

1

0

High-throughput

0.438

High

865494

YJ26
Uncharacterized protein YJR056C

1

0

High-throughput

0.438

High

871525

HGH1
Protein HGH1

1

0

High-throughput

0.438

High

918071

PIB2
Glutamine sensor PIB2

1

0

High-throughput

0.438

High

919762

PXR1
Protein PXR1

1

0

High-throughput

0.438

High

920938

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.438

High

924943

NST1
Stress response protein NST1

1

0

High-throughput

0.438

High

1038821

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.438

High

1042456

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

1

0

High-throughput

0.438

High

1042838

EBS1
Nonsense-mediated mRNA decay factor EBS1

1

0

High-throughput

0.438

High

1043249

TMA23
Protein TMA23

1

0

High-throughput

0.438

High

1047521

RRN11
RNA polymerase I-specific transcription initiation factor RRN11

1

0

High-throughput

0.438

High

1054989

BFR2
Protein BFR2

1

0

High-throughput

0.438

High

1054991

ELP1
Elongator complex protein 1

1

0

High-throughput

0.438

High

1055007

GIN4
Serine/threonine-protein kinase GIN4

1

0

High-throughput

0.438

High

1055010

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.438

High

1055012

NOP56
Nucleolar protein 56

1

0

High-throughput

0.438

High

393375

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

752768

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

776654

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.426

High

804753

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.426

High

806823

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.426

High

816422

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.426

High

924496

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

548238

BIK1
Nuclear fusion protein BIK1

1

1

High-throughput

0.417

High

1035274

NUP49
Nucleoporin NUP49/NSP49

1

1

High-throughput

0.417

High

1054994

ATG20
Autophagy-related protein 20

1

1

High-throughput

0.417

High

1053560

SN309
Pre-mRNA-splicing factor SNT309

2

0

Small-scale

0.328

High

1055005

CWC2
Pre-mRNA-splicing factor CWC2

2

0

High-throughput

0.328

High

797998

ATG12
Ubiquitin-like protein ATG12

2

0

High-throughput

0.295

High

798545

BIT2
Probable target of rapamycin complex 2 subunit BIT2

2

0

High-throughput

0.295

High

829745

CHS6
Chitin biosynthesis protein CHS6

2

0

High-throughput

0.295

High

864679

SNX4
Sorting nexin-4

1

0

Small-scale

0.282

High

797693

NTC20
Pre-mRNA-splicing factor NTC20

1

0

Small-scale

0.279

Low

829961

PRP17
Pre-mRNA-processing factor 17

1

0

High-throughput

0.279

Low

744796

LAA2
Clathrin adapter accessory protein LAA2

1

0

High-throughput

0.238

Low

780472

YKP3
Putative uncharacterized protein YKL153W

1

0

High-throughput

0.238

Low

796766

YBU6
Probable thioesterase YBR096W

1

0

High-throughput

0.238

Low

796831

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.238

Low

816053

BOI2
BEM1-interacting protein 2

1

0

High-throughput

0.238

Low

823173

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.238

Low

849602

SNZ3
Probable pyridoxal 5'-phosphate synthase subunit SNZ3

1

0

High-throughput

0.238

Low

850384

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.238

Low

893114

KEL2
Kelch repeat-containing protein 2

1

0

High-throughput

0.238

Low

914916

SC6B2
Protein transport protein SBH2

1

0

High-throughput

0.238

Low

918588

YG2G
Putative uncharacterized protein YGR079W

1

0

High-throughput

0.238

Low

919465

CENPQ
Inner kinetochore subunit OKP1

1

0

High-throughput

0.238

Low

923290

YN91
Uncharacterized membrane protein YNR062C

1

0

High-throughput

0.238

Low

1054995

ADY3
Accumulates dyads protein 3

1

0

High-throughput

0.238

Low

1054997

YL031
Putative uncharacterized protein YLR031W

1

0

High-throughput

0.238

Low

1054998

YO036
Uncharacterized protein YOL036W

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025