HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11071869
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0017124 - SH3 domain binding and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Hs			1 665
+	Hs
		1060706 SOS1_HUMAN (1-1333): 0: 1000: 100.00		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		1060728 SOS2_HUMAN (1-1131): 0: 858: 73.59		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		1060679 SOS1_HUMAN (1-1333): 0: 1000: 100.00		SPD2A_HUMAN (3-650): 8.88e-37: 150: 16.74
+	Hs
		987577 SOS1_HUMAN (1-1333): 0: 1000: 100.00		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		593974 SOS1_HUMAN (1-1333): 0: 1000: 100.00		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Mm
		1221225 SOS1_MOUSE (1-1333): 0: 965: 96.47		GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37
+	Hs
		222064 SOS1_HUMAN (1-1333): 0: 1000: 100.00		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24
+	Hs
		1060677 SOS1_HUMAN (1-1333): 0: 1000: 100.00		ITSN1_HUMAN (77-423): 3.02e-14: 78.9: 14.56
+	Hs
		1060697 SOS1_HUMAN (1-1333): 0: 1000: 100.00		ITSN2_HUMAN (214-418): 8.13e-14: 77.4: 15.61
+	Hs
		987578 SOS2_HUMAN (1-1131): 0: 858: 73.59		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Mm
		1036602 SOS2_MOUSE (1-1098): 0: 848: 74.52		GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37
+	Hs
		593975 SOS2_HUMAN (1-1131): 0: 858: 73.59		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Hs
		222065 SOS2_HUMAN (1-1131): 0: 858: 73.59		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24
+	Hs
		292826 SOS2_HUMAN (1-1131): 0: 858: 73.59		GRAP2_HUMAN (1-58): 2.52e-17: 85.5: 31.03
+	Hs
		1060709 SOS2_HUMAN (1-1131): 0: 858: 73.59		ITSN1_HUMAN (77-423): 3.02e-14: 78.9: 14.56
+	Hs
		1060722 SOS2_HUMAN (1-1131): 0: 858: 73.59		ITSN2_HUMAN (214-418): 8.13e-14: 77.4: 15.61
+	Dm
		688355 SOS_DROME (8-1333): 0: 704: 41.74		GRAP_DROME (2-157): 3.83e-32: 125: 18.01
+	Ce
		711469 SOS_CAEEL (15-1289): 0: 579: 27.19		SEM5_CAEEL (4-70): 2.01e-20: 92.7: 35.82
+	Mm
		1221249 Q91ZZ2_MOUSE (599-1020): 2.19e-92: 325: 25.12		GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37
+	Hs
		593989 RPGF1_HUMAN (571-1032): 2.17e-92: 324: 23.63		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62