HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32203420, 14679214
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0017124 - SH3 domain binding GO:0048011 - neurotrophin TRK receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Hs			1 639
+	Hs
		1060690 SOS1_HUMAN (1-1333): 0: 1000: 100.00		SH3K1_HUMAN (1-638): 4.71e-90: 295: 31.85
+	Hs
		1060728 SOS2_HUMAN (1-1131): 0: 858: 73.59		CD2AP_HUMAN (1-639): 1.27e-133: 407: 100.00
+	Hs
		222064 SOS1_HUMAN (1-1333): 0: 1000: 100.00		NCK2_HUMAN (2-361): 1.15e-52: 187: 15.86
+	Hs
		1060677 SOS1_HUMAN (1-1333): 0: 1000: 100.00		ITSN1_HUMAN (2-336): 1.35e-45: 176: 19.76
+	Hs
		1060697 SOS1_HUMAN (1-1333): 0: 1000: 100.00		ITSN2_HUMAN (2-336): 7.69e-44: 171: 18.29
+	Hs
		987577 SOS1_HUMAN (1-1333): 0: 1000: 100.00		GRB2_HUMAN (2-168): 2.29e-41: 151: 18.06
+	Mm
		1221225 SOS1_MOUSE (1-1333): 0: 965: 96.47		GRB2_MOUSE (2-168): 7.7e-42: 152: 18.06
+	Hs
		593974 SOS1_HUMAN (1-1333): 0: 1000: 100.00		NCK1_HUMAN (113-396): 2.7e-26: 113: 14.38
+	Hs
		1060679 SOS1_HUMAN (1-1333): 0: 1000: 100.00		SPD2A_HUMAN (61-291): 1.07e-09: 63.7: 13.50
+	Hs
		222065 SOS2_HUMAN (1-1131): 0: 858: 73.59		NCK2_HUMAN (2-361): 1.15e-52: 187: 15.86
+	Hs
		1060709 SOS2_HUMAN (1-1131): 0: 858: 73.59		ITSN1_HUMAN (2-336): 1.35e-45: 176: 19.76
+	Hs
		1060722 SOS2_HUMAN (1-1131): 0: 858: 73.59		ITSN2_HUMAN (2-336): 7.69e-44: 171: 18.29
+	Hs
		292826 SOS2_HUMAN (1-1131): 0: 858: 73.59		GRAP2_HUMAN (2-330): 4.32e-42: 157: 13.37
+	Hs
		987578 SOS2_HUMAN (1-1131): 0: 858: 73.59		GRB2_HUMAN (2-168): 2.29e-41: 151: 18.06
+	Mm
		1036602 SOS2_MOUSE (1-1098): 0: 848: 74.52		GRB2_MOUSE (2-168): 7.7e-42: 152: 18.06
+	Hs
		593975 SOS2_HUMAN (1-1131): 0: 858: 73.59		NCK1_HUMAN (113-396): 2.7e-26: 113: 14.38
+	Dm
		688355 SOS_DROME (8-1333): 0: 704: 41.74		GRAP_DROME (111-328): 4.03e-38: 142: 16.44
+	Ce
		711469 SOS_CAEEL (15-1289): 0: 579: 27.19		SEM5_CAEEL (2-176): 2.22e-36: 138: 18.92
+	Mm
		1221249 Q91ZZ2_MOUSE (599-1020): 2.19e-92: 325: 25.12		GRB2_MOUSE (2-168): 7.7e-42: 152: 18.06
+	Hs
		593989 RPGF1_HUMAN (571-1032): 2.17e-92: 324: 23.63		NCK1_HUMAN (113-396): 2.7e-26: 113: 14.38