Interactor 1: ARHG5 (Q12774)
Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
Gene: ARHGEF5
Interactor 2: PKHG4 (Q58EX7)
Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)
Gene: PLEKHG4
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.61 | 1.00 | 0.783 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32296183, unassigned1304 |
| Identification Methods | two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PH~RhoGEF, RhoGEF~RhoGEF, RhoGEF~SOS1_NGEF_PH, RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH |
| Common GO terms | GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0051056 - regulation of small GTPase mediated signal transduction |
| Homologous interactions | 12 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
