HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: RCOR3 (Q9P2K3)
REST corepressor 3
Gene: RCOR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0003714 - transcription corepressor activity GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 495
+	Hs
		1038768 HDAC1_HUMAN (3-385): 0: 588: 62.92		RCOR3_HUMAN (1-495): 1.17e-141: 418: 100.00
+	Hs
		177402 HDAC3_HUMAN (1-428): 0: 600: 100.00		RCOR1_HUMAN (1-384): 4.93e-99: 308: 62.69
+	Mm
		140301 HDAC1_MOUSE (3-385): 0: 588: 62.92		RCOR1_MOUSE (1-385): 5.12e-99: 308: 63.57
+	Mm
		140317 HDAC1_MOUSE (3-385): 0: 588: 62.92		MTA2_MOUSE (1-478): 1.74e-92: 297: 15.53
+	Hs
		296017 HDAC1_HUMAN (3-385): 0: 588: 62.92		MTA2_HUMAN (1-478): 7.19e-92: 295: 15.71
+	Hs
		1038521 HDAC1_HUMAN (3-385): 0: 588: 62.92		RCOR2_HUMAN (1-494): 4.22e-92: 291: 55.44
+	Hs
		1038676 HDAC1_HUMAN (3-385): 0: 588: 62.92		MTA3_HUMAN (1-418): 1.98e-89: 287: 15.86
+	Hs
		1031849 HDAC1_HUMAN (3-385): 0: 588: 62.92		MTA1_HUMAN (1-433): 2.17e-85: 279: 15.62
+	Mm
		140302 HDAC1_MOUSE (3-385): 0: 588: 62.92		MTA1_MOUSE (1-433): 5.29e-85: 278: 15.82
+	Hs
		91458 HDAC1_HUMAN (3-385): 0: 588: 62.92		E7EQY4_HUMAN (1-316): 2.28e-81: 263: 17.90
+	Mm
		292414 HDAC3_MOUSE (1-428): 0: 601: 99.77		NCOR1_MOUSE (35-479): 1.8e-54: 199: 18.65
+	Hs
		177153 HDAC3_HUMAN (1-428): 0: 600: 100.00		NCOR1_HUMAN (35-484): 1.63e-51: 191: 17.04
+	Hs
		177416 HDAC3_HUMAN (1-428): 0: 600: 100.00		NCOR2_HUMAN (35-478): 1.59e-48: 182: 18.57
+	Hs
		261500 HDAC1_HUMAN (3-385): 0: 588: 62.92		NCOR1_HUMAN (35-484): 1.63e-51: 191: 17.04
+	Mm
		140291 HDAC1_MOUSE (3-385): 0: 588: 62.92		RERE_MOUSE (1-495): 3.41e-51: 189: 17.00
+	Hs
		1038770 HDAC1_HUMAN (3-385): 0: 588: 62.92		RERE_HUMAN (1-495): 8.77e-50: 185: 16.40
+	Hs
		1038488 HDAC1_HUMAN (3-385): 0: 588: 62.92		MIER3_HUMAN (1-238): 1.22e-49: 180: 20.54
+	Hs
		1038636 HDAC1_HUMAN (3-385): 0: 588: 62.92		TREF1_HUMAN (1-314): 6.01e-45: 171: 20.48
+	Hs
		1038533 HDAC1_HUMAN (3-385): 0: 588: 62.92		MIER2_HUMAN (1-306): 1.16e-43: 163: 18.98
+	Hs
		1038525 HDAC1_HUMAN (3-385): 0: 588: 62.92		MIER1_HUMAN (1-307): 1.08e-41: 157: 18.68