HitPredict

Interactor 1: NLRX1 (Q86UT6)
NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9)
Gene: NLRX1

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21703539
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 975 Hs			1 522
+	Mm
		999832 NLRX1_MOUSE (1-974): 0: 710: 90.25		TRAF6_MOUSE (1-522): 1.79e-139: 414: 87.93
+	Mm
		1189493 NLRX1_MOUSE (1-974): 0: 710: 90.25		TRAF3_MOUSE (20-501): 9.91e-83: 269: 22.40
+	Hs
		1094922 NLRX1_HUMAN (1-975): 0: 702: 100.00		TRAF3_HUMAN (19-501): 1.51e-83: 271: 22.18
+	Hs
		1438573 NOD2_HUMAN (115-925): 5.45e-118: 388: 20.65		TRAF6_HUMAN (1-522): 3.21e-150: 441: 100.00
+	Hs
		1414782 NOD2_HUMAN (115-925): 5.45e-118: 388: 20.65		TRAF4_HUMAN (54-500): 7.12e-89: 282: 26.11
+	Hs
		1414806 NOD1_HUMAN (63-908): 1.27e-114: 377: 17.91		TRAF4_HUMAN (54-500): 7.12e-89: 282: 26.11
+	Hs
		142673 NLRP6_HUMAN (73-867): 2.1e-131: 420: 20.05		TRI38_HUMAN (62-410): 1.15e-43: 162: 12.47
+	Hs
		749485 C2TA_HUMAN (15-840): 7.6e-124: 406: 16.61		TRI22_HUMAN (56-379): 7.38e-41: 155: 14.11
+	Hs
		572225 NOD2_HUMAN (115-925): 5.45e-118: 388: 20.65		TRI27_HUMAN (57-410): 6.48e-45: 167: 13.21
+	Hs
		749472 C2TA_HUMAN (15-840): 7.6e-124: 406: 16.61		TRI26_HUMAN (61-410): 8.88e-38: 147: 14.43
+	Hs
		1294331 NOD2_HUMAN (115-925): 5.45e-118: 388: 20.65		TRI50_HUMAN (60-410): 1.75e-43: 162: 13.57
+	Hs
		1315295 NOD2_HUMAN (115-925): 5.45e-118: 388: 20.65		TRI22_HUMAN (56-379): 7.38e-41: 155: 14.11
+	Hs
		1292006 NAL10_HUMAN (68-597): 6.22e-109: 353: 17.00		TRI31_HUMAN (58-334): 2.83e-35: 138: 15.00
+	Hs
		247409 PHLP1_HUMAN (480-975): 4.24e-34: 144: 11.52		TRI11_HUMAN (59-410): 7.87e-51: 182: 14.21
+	Hs
		947347 NAL12_HUMAN (502-855): 9.45e-28: 123: 17.62		TRI25_HUMAN (63-370): 4.82e-45: 169: 18.61
+	Hs
		1231193 NLRP1_HUMAN (818-974): 1.45e-13: 77.5: 16.88		TRI68_HUMAN (60-410): 1.98e-46: 170: 12.40
+	Hs
		1125219 NLRP1_HUMAN (818-974): 1.45e-13: 77.5: 16.88		TRI25_HUMAN (63-370): 4.82e-45: 169: 18.61
+	Mm
		1189993 NLRP3_MOUSE (761-974): 4.04e-11: 69.4: 14.10		Q3UCL2_MOUSE (60-409): 1.05e-47: 173: 15.15
+	Mm
		1283501 NLRP3_MOUSE (761-974): 4.04e-11: 69.4: 14.10		TRI50_MOUSE (60-410): 6.21e-44: 164: 14.13
+	Hs
		1294327 NLRP3_HUMAN (457-745): 1.02e-09: 64.8: 10.51		TRI50_HUMAN (60-410): 1.75e-43: 162: 13.57