HitPredict

Interactor 1: SOCS7 (O14512)
Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Gene: SOCS7

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	15677474
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~STAT_linker, SH2~SOCS_box
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035591 - signaling adaptor activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 581 Hs			1 770
+	Hs
		155155 SOCS7_HUMAN (1-581): 0: 569: 100.00		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		205458 SOCS3_MOUSE (382-551): 2.96e-37: 139: 25.13		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		155919 SOCS3_HUMAN (382-551): 2.93e-35: 134: 25.13		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		273308 SOCS5_HUMAN (248-565): 5.32e-66: 226: 20.30		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		699623 P85A_HUMAN (371-499): 2.27e-14: 78.5: 17.42		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		827867 P55G_HUMAN (389-523): 3.93e-14: 76.9: 21.32		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		136320 P85B_HUMAN (389-493): 9.49e-14: 76.2: 23.59		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		855625 CRK_HUMAN (388-568): 5.08e-51: 179: 20.77		STAT4_HUMAN (1-729): 0: 893: 48.44
+	Hs
		155092 SOCS2_HUMAN (366-554): 1.39e-58: 195: 30.73		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Mm
		838410 CISH_MOUSE (322-554): 5.44e-48: 169: 24.51		STA5A_MOUSE (1-734): 0: 757: 30.46
+	Hs
		907292 CISH_HUMAN (322-554): 5.7e-47: 167: 24.23		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		838391 CISH_HUMAN (322-554): 5.7e-47: 167: 24.23		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		855838 CRKL_HUMAN (392-566): 1.61e-37: 142: 18.75		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		838343 CRKL_HUMAN (392-566): 1.61e-37: 142: 18.75		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Dm
		1172562 Q8INY1_DROME (262-577): 1.79e-61: 218: 23.55		STAT_DROME (1-755): 0: 648: 22.58
+	Dm
		1172557 Q7JVF1_DROME (352-549): 4.44e-62: 210: 29.29		STAT_DROME (1-755): 0: 648: 22.58
+	Hs
		907284 P55G_HUMAN (389-523): 3.93e-14: 76.9: 21.32		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Mm
		205462 SOCS3_MOUSE (382-551): 2.96e-37: 139: 25.13		STAT6_MOUSE (1-761): 0: 668: 25.69