HitPredict

Interactor 1: SOCS7 (O14512)
Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Gene: SOCS7

Interactor 2: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15677474
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~STAT_linker, SH2~SOCS_box
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 581 Hs			1 794
+	Hs
		155154 SOCS7_HUMAN (1-581): 0: 569: 100.00		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		838391 CISH_HUMAN (322-554): 5.7e-47: 167: 24.23		STA5A_HUMAN (1-794): 0: 1050: 100.00
+	Mm
		838410 CISH_MOUSE (322-554): 5.44e-48: 169: 24.51		STA5A_MOUSE (1-794): 0: 1043: 96.35
+	Hs
		155092 SOCS2_HUMAN (366-554): 1.39e-58: 195: 30.73		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		838343 CRKL_HUMAN (392-566): 1.61e-37: 142: 18.75		STA5A_HUMAN (1-794): 0: 1050: 100.00
+	Hs
		907292 CISH_HUMAN (322-554): 5.7e-47: 167: 24.23		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		855838 CRKL_HUMAN (392-566): 1.61e-37: 142: 18.75		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		907284 P55G_HUMAN (389-523): 3.93e-14: 76.9: 21.32		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		273308 SOCS5_HUMAN (248-565): 5.32e-66: 226: 20.30		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Dm
		1172562 Q8INY1_DROME (262-577): 1.79e-61: 218: 23.55		STAT_DROME (1-726): 0: 703: 29.95
+	Dm
		1172557 Q7JVF1_DROME (352-549): 4.44e-62: 210: 29.29		STAT_DROME (1-726): 0: 703: 29.95
+	Hs
		855625 CRK_HUMAN (388-568): 5.08e-51: 179: 20.77		STAT4_HUMAN (1-738): 0: 715: 29.34
+	Mm
		205458 SOCS3_MOUSE (382-551): 2.96e-37: 139: 25.13		STAT3_MOUSE (1-723): 0: 737: 29.94
+	Hs
		155919 SOCS3_HUMAN (382-551): 2.93e-35: 134: 25.13		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Mm
		205462 SOCS3_MOUSE (382-551): 2.96e-37: 139: 25.13		STAT6_MOUSE (1-766): 0: 698: 38.69
+	Hs
		699623 P85A_HUMAN (371-499): 2.27e-14: 78.5: 17.42		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		827867 P55G_HUMAN (389-523): 3.93e-14: 76.9: 21.32		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		136320 P85B_HUMAN (389-493): 9.49e-14: 76.2: 23.59		STAT3_HUMAN (1-723): 0: 736: 29.94