HitPredict

Interactor 1: KLK1 (P06870)
Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)
Gene: KLK1

Interactor 2: KAIN (P29622)
Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)
Gene: SERPINA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10862973
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005615 - extracellular space GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 427
+	Hs
		369296 KLK1_HUMAN (1-262): 3.96e-125: 357: 100.00		A1AT_HUMAN (4-426): 8.89e-167: 476: 42.55
+	Hs
		369437 KLK2_HUMAN (1-261): 4.75e-115: 332: 65.90		AACT_HUMAN (19-426): 5.46e-171: 487: 44.25
+	Hs
		369520 KLK13_HUMAN (1-260): 1.51e-105: 308: 40.07		AACT_HUMAN (19-426): 5.46e-171: 487: 44.25
+	Hs
		369297 KLK3_HUMAN (1-261): 3.99e-108: 314: 60.54		A1AT_HUMAN (4-426): 8.89e-167: 476: 42.55
+	Mm
		459955 Q9Z1R9_MOUSE (5-261): 2.6e-114: 329: 40.86		A1AT1_MOUSE (30-425): 1.52e-157: 452: 43.07
+	Hs
		425167 KLK2_HUMAN (1-261): 4.75e-115: 332: 65.90		IPSP_HUMAN (31-424): 5.05e-156: 448: 44.92
+	Hs
		369234 KLK1_HUMAN (1-262): 3.96e-125: 357: 100.00		ANT3_HUMAN (25-424): 3.37e-144: 420: 31.39
+	Hs
		425160 KLK3_HUMAN (1-261): 3.99e-108: 314: 60.54		IPSP_HUMAN (31-424): 5.05e-156: 448: 44.92
+	Hs
		457955 TRY1_HUMAN (5-262): 3.07e-114: 329: 40.31		SPB8_HUMAN (51-424): 4.57e-146: 421: 30.79
+	Hs
		628392 KLK2_HUMAN (1-261): 4.75e-115: 332: 65.90		SPB6_HUMAN (51-424): 2.16e-144: 417: 30.79
+	Hs
		398000 KLKB1_HUMAN (22-261): 3.78e-90: 280: 32.55		IPSP_HUMAN (31-424): 5.05e-156: 448: 44.92
+	Hs
		767104 KLK13_HUMAN (1-260): 1.51e-105: 308: 40.07		SPB6_HUMAN (51-424): 2.16e-144: 417: 30.79
+	Mm
		1221626 KLK8_MOUSE (2-260): 1.88e-102: 300: 42.86		SPB6_MOUSE (51-424): 2.82e-146: 422: 31.84
+	Hs
		762249 TRY3_HUMAN (11-262): 1.63e-109: 319: 41.67		SPB12_HUMAN (50-424): 2.89e-135: 395: 30.71
+	Hs
		895465 TMPSD_HUMAN (8-258): 2.88e-89: 277: 30.08		SPB8_HUMAN (51-424): 4.57e-146: 421: 30.79
+	Hs
		369417 KLK4_HUMAN (23-258): 1.1e-50: 168: 40.08		A1AT_HUMAN (4-426): 8.89e-167: 476: 42.55
+	Hs
		210637 KLK10_HUMAN (28-261): 4.37e-46: 157: 37.29		A1AT_HUMAN (4-426): 8.89e-167: 476: 42.55
+	Hs
		210726 KLK10_HUMAN (28-261): 4.37e-46: 157: 37.29		SPB10_HUMAN (50-424): 2.4e-148: 428: 29.07
+	Hs
		210686 KLK10_HUMAN (28-261): 4.37e-46: 157: 37.29		CBG_HUMAN (51-424): 1.03e-147: 427: 45.19
+	Hs
		210682 KLK10_HUMAN (28-261): 4.37e-46: 157: 37.29		HEP2_HUMAN (32-426): 1.18e-42: 158: 29.14