HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	31527615, 34591612, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 142
+	Hs
		369303 ESR1_HUMAN (1-595): 0: 599: 100.00		COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30
+	Hs
		370172 ESR1_HUMAN (1-595): 0: 599: 100.00		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Hs
		1270063 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44
+	Hs
		1269526 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		864095 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00
+	Hs
		902348 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30
+	Mm
		509310 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		AP2M1_MOUSE (1-138): 1.82e-41: 144: 15.22
+	Hs
		487881 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		AP1M2_HUMAN (2-142): 3.16e-44: 151: 19.44