HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: PK1IP (Q9NWT1)
p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)
Gene: PAK1IP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0042273 - ribosomal large subunit biogenesis
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 294 Hs			1 392
+	Hs
		418805 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		FBW1A_HUMAN (2-286): 6.86e-64: 216: 16.72
+	Hs
		418717 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		NLE1_HUMAN (154-389): 4e-38: 144: 10.04
+	Hs
		418109 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		WDR5_HUMAN (202-377): 2.11e-30: 120: 13.66
+	Hs
		418519 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		FBXW7_HUMAN (1-146): 6.23e-26: 111: 19.48
+	Mm
		1143203 NPM_MOUSE (1-294): 7.04e-141: 400: 93.54		FBXW7_MOUSE (1-146): 3.61e-26: 112: 19.48
+	Hs
		418535 NPM_HUMAN (1-294): 1.47e-143: 407: 100.00		SNR40_HUMAN (237-391): 4.8e-13: 71.8: 9.62
+	Hs
		271435 NPM3_HUMAN (10-119): 6.13e-58: 185: 43.75		PK1IP_HUMAN (1-392): 6.72e-91: 280: 100.00
+	Hs
		271432 NPM3_HUMAN (10-119): 6.13e-58: 185: 43.75		NLE1_HUMAN (154-389): 4e-38: 144: 10.04