HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: SMYD3 (Q9H7B4)
Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.354) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1)
Gene: SMYD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 428
+	Hs
		432269 HS90A_HUMAN (1-724): 0: 1072: 85.25		SMYD3_HUMAN (1-428): 4.56e-159: 457: 100.00
+	Hs
		432292 HS90A_HUMAN (1-724): 0: 1072: 85.25		SMYD2_HUMAN (6-420): 1.58e-131: 387: 31.54
+	Hs
		1123460 H90B3_HUMAN (1-724): 0: 815: 75.83		SMYD3_HUMAN (1-428): 4.56e-159: 457: 100.00
+	Hs
		1123439 H90B4_HUMAN (25-596): 0: 639: 71.85		SMYD3_HUMAN (1-428): 4.56e-159: 457: 100.00
+	Sc
		367142 HSP82_YEAST (12-724): 0: 927: 61.26		SET6_YEAST (102-271): 5.72e-35: 135: 23.30
+	Sc
		544656 HSC82_YEAST (13-724): 0: 922: 60.22		SET6_YEAST (102-271): 5.72e-35: 135: 23.30