HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	9573010
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 508
+	Mm
		575627 LYN_MOUSE (1-512): 0: 621: 96.09		EPOR_MOUSE (1-508): 7.19e-140: 414: 81.69
+	Hs
		557076 SRC_HUMAN (1-510): 0: 591: 51.97		EPOR_HUMAN (1-508): 8.74e-145: 427: 100.00
+	Hs
		463721 LYN_HUMAN (1-512): 0: 621: 100.00		CSF3R_HUMAN (14-425): 2.43e-50: 186: 13.92
+	Hs
		439931 LCK_HUMAN (1-512): 0: 585: 63.62		IL2RB_HUMAN (17-488): 2.5e-64: 220: 17.52
+	Hs
		440345 FYN_HUMAN (1-510): 0: 583: 54.31		IL7RA_HUMAN (109-477): 4.78e-65: 219: 15.65
+	Hs
		473464 HCK_HUMAN (1-512): 0: 601: 70.70		CSF3R_HUMAN (14-425): 2.43e-50: 186: 13.92
+	Mm
		465769 HCK_MOUSE (1-512): 0: 595: 69.92		CSF3R_MOUSE (14-399): 4.46e-42: 162: 15.08
+	Mm
		440273 LCK_MOUSE (1-512): 0: 592: 63.81		CSF3R_MOUSE (14-399): 4.46e-42: 162: 15.08
+	Hs
		596942 TEC_HUMAN (35-505): 1.07e-162: 477: 35.27		PRLR_HUMAN (40-499): 4.22e-85: 276: 18.03
+	Hs
		440383 FYN_HUMAN (1-510): 0: 583: 54.31		IL3RA_HUMAN (37-316): 5.01e-41: 153: 20.00
+	Hs
		440392 FYN_HUMAN (1-510): 0: 583: 54.31		EPHA8_HUMAN (2-369): 1.82e-38: 152: 13.80
+	Hs
		473376 HCK_HUMAN (1-512): 0: 601: 70.70		IL6RB_HUMAN (64-483): 1.75e-23: 106: 12.72
+	Hs
		463369 LYN_HUMAN (1-512): 0: 621: 100.00		IL3RB_HUMAN (17-244): 4.63e-09: 61.2: 14.34
+	Hs
		439918 LCK_HUMAN (1-512): 0: 585: 63.62		PTPRF_HUMAN (8-269): 5.22e-13: 73.9: 16.31
+	Hs
		440313 FYN_HUMAN (1-510): 0: 583: 54.31		PTPRF_HUMAN (8-269): 5.22e-13: 73.9: 16.31
+	Mm
		59107 FYN_MOUSE (1-510): 0: 583: 54.12		PTPRF_MOUSE (6-234): 1.46e-11: 69.2: 17.24
+	Hs
		440407 FYN_HUMAN (1-510): 0: 583: 54.31		IL3RB_HUMAN (17-244): 4.63e-09: 61.2: 14.34
+	Hs
		710700 BTK_HUMAN (26-505): 7.72e-159: 468: 35.15		EPHA8_HUMAN (2-369): 1.82e-38: 152: 13.80