HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 776
+	Hs
		1140198 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		ARHG6_HUMAN (1-776): 0: 611: 100.00
+	Hs
		988376 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		ARHG6_HUMAN (1-776): 0: 611: 100.00
+	Gg
		1221097 Q6LC82_CHICK (10-195): 2.03e-80: 239: 63.98		ARHG6_CHICK (1-775): 0: 588: 73.55
+	Hs
		1121983 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		ARHG7_HUMAN (1-719): 2.46e-170: 512: 53.96
+	Hs
		601284 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		ARHG7_HUMAN (1-719): 2.46e-170: 512: 53.96
+	Hs
		988358 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		ARHG7_HUMAN (1-719): 2.46e-170: 512: 53.96
+	Hs
		1433596 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		FARP1_HUMAN (3-599): 1.68e-88: 303: 14.61
+	Hs
		584511 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		VAV_HUMAN (1-746): 3.75e-117: 375: 16.33
+	Hs
		51111 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		PKHG3_HUMAN (224-727): 9.3e-84: 291: 19.53
+	Hs
		913637 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		VAV2_HUMAN (1-746): 1.98e-107: 350: 15.26
+	Hs
		988618 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		SPT13_HUMAN (102-638): 8.18e-104: 335: 17.61
+	Hs
		601516 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		FARP1_HUMAN (3-599): 1.68e-88: 303: 14.61
+	Hs
		601497 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		PKHG1_HUMAN (190-720): 1.56e-84: 295: 19.74
+	Hs
		51039 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		PKHG3_HUMAN (224-727): 9.3e-84: 291: 19.53
+	Hs
		51067 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		PKHG3_HUMAN (224-727): 9.3e-84: 291: 19.53
+	Hs
		988495 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		ARHGP_HUMAN (210-656): 3.44e-88: 291: 18.55
+	Hs
		988545 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		PREX1_HUMAN (218-552): 6.02e-83: 291: 23.40
+	Hs
		988472 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		PREX2_HUMAN (220-543): 1.25e-82: 290: 21.11
+	Hs
		299534 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		TRIO_HUMAN (230-567): 5.13e-73: 262: 20.46
+	Hs
		238812 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		KALRN_HUMAN (203-773): 4.72e-62: 229: 16.07