HitPredict

Interactor 1: AT2B4 (P23634)
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene: ATP2B4

Interactor 2: PE2R3 (P43115)
Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
Gene: PTGER3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1241 Hs			1 390
+	Hs
		428921 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		ADRB2_HUMAN (15-367): 1.23e-67: 221: 13.37
+	Hs
		619204 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		APJ_HUMAN (37-390): 1.01e-63: 210: 14.41
+	Hs
		208448 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		OX2R_HUMAN (44-385): 6.11e-62: 207: 15.14
+	Hs
		619206 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		OPRX_HUMAN (16-378): 7.57e-61: 202: 16.80
+	Hs
		619283 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		NMUR2_HUMAN (53-388): 6.7e-54: 185: 16.81
+	Hs
		208456 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		OX2R_HUMAN (44-385): 6.11e-62: 207: 15.14
+	Hs
		793180 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		PI2R_HUMAN (48-380): 3.24e-66: 216: 29.50
+	Hs
		619282 AT2B4_HUMAN (1-1241): 0: 1300: 100.00		HCAR1_HUMAN (43-358): 1.42e-11: 67.1: 18.30
+	Hs
		781059 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		OPRX_HUMAN (16-378): 7.57e-61: 202: 16.80
+	Hs
		793076 AT2B3_HUMAN (1-1241): 0: 1164: 71.63		PF2R_HUMAN (46-365): 4.22e-61: 202: 34.06
+	Hs
		208453 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		OX2R_HUMAN (44-385): 6.11e-62: 207: 15.14
+	Hs
		781053 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		OPRX_HUMAN (16-378): 7.57e-61: 202: 16.80
+	Hs
		793074 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		PF2R_HUMAN (46-365): 4.22e-61: 202: 34.06
+	Hs
		622997 AT2B2_HUMAN (3-1241): 0: 1154: 68.59		EDNRB_HUMAN (5-388): 2.31e-59: 200: 13.85
+	Hs
		530844 AT1A3_HUMAN (27-1052): 0: 766: 24.34		OPRX_HUMAN (16-378): 7.57e-61: 202: 16.80
+	Hs
		530964 AT1A3_HUMAN (27-1052): 0: 766: 24.34		NPFF1_HUMAN (9-380): 7.06e-60: 201: 13.07
+	Hs
		530831 AT1A3_HUMAN (27-1052): 0: 766: 24.34		EDNRB_HUMAN (5-388): 2.31e-59: 200: 13.85
+	Hs
		392982 AT1A1_HUMAN (34-1053): 0: 737: 23.37		ADRB2_HUMAN (15-367): 1.23e-67: 221: 13.37
+	Hs
		428908 AT2A2_HUMAN (45-1066): 0: 733: 25.98		ADRB2_HUMAN (15-367): 1.23e-67: 221: 13.37
+	Hs
		530835 AT1A3_HUMAN (27-1052): 0: 766: 24.34		PTAFR_HUMAN (49-361): 6.16e-12: 68.3: 19.75