HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2V1 (Q13404)
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)
Gene: UBE2V1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37558718
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 147
+	Hs
		647561 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2V2_HUMAN (4-147): 9.57e-72: 213: 88.89
+	Hs
		647506 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (12-147): 6.79e-59: 181: 24.27
+	Hs
		647684 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (12-146): 2.62e-59: 181: 24.44
+	Hs
		647533 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (12-146): 7.46e-58: 178: 22.96
+	Hs
		647502 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (9-146): 1.76e-57: 177: 22.46
+	Hs
		647521 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (12-146): 2.66e-57: 176: 22.96
+	Hs
		647537 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (9-146): 9.3e-57: 175: 21.74
+	Hs
		144164 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2C_HUMAN (2-147): 3.93e-56: 174: 25.17
+	Hs
		647619 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (1-145): 1.29e-55: 174: 22.76
+	Hs
		647626 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (2-145): 1.73e-55: 174: 23.61
+	Hs
		647538 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBC9_HUMAN (9-145): 4.64e-55: 171: 21.01
+	Hs
		647508 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (7-124): 1.46e-12: 63.8: 29.37
+	Dm
		1345305 Q8T0L3_DROME (36-1057): 0: 1108: 59.75		Q9VRL1_DROME (1-145): 5.85e-73: 216: 66.90
+	Sp
		314596 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (12-146): 8.79e-58: 178: 23.70
+	Sc
		585681 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (11-146): 2.79e-56: 174: 21.32
+	Sc
		438521 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC2_YEAST (9-147): 1.11e-55: 173: 20.14
+	Hs
		48347 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (12-147): 6.79e-59: 181: 24.27
+	Hs
		48351 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (12-146): 7.46e-58: 178: 22.96
+	Hs
		48349 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (12-146): 2.66e-57: 176: 22.96
+	Sp
		268150 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC1_SCHPO (13-132): 7.74e-14: 67.6: 30.58