HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: PTPRJ (Q12913)
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
Gene: PTPRJ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	19167335, 19494114
Identification Methods	phosphatase assay, peptide array, pull down, anti tag coimmunoprecipitation
Interaction Type	dephosphorylation reaction, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0010759 - positive regulation of macrophage chemotaxis
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 379 Hs			1 1337
+	Hs
		658916 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		PTPRJ_HUMAN (1-1337): 0: 925: 100.00
+	Hs
		617037 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		PTPRE_HUMAN (760-1299): 4.03e-95: 323: 22.26
+	Hs
		617041 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		PTPRE_HUMAN (760-1299): 4.03e-95: 323: 22.26
+	Hs
		647498 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		DCC_HUMAN (270-1127): 5.82e-71: 264: 10.61
+	Hs
		658833 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		DCC_HUMAN (270-1127): 5.82e-71: 264: 10.61
+	Rn
		926490 MK01_RAT (28-374): 6.16e-154: 439: 87.61		DCC_RAT (270-1127): 2.7e-71: 264: 10.72
+	Hs
		617077 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		PTPRG_HUMAN (757-1329): 3.11e-55: 213: 17.43
+	Hs
		647584 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		PTPRK_HUMAN (25-498): 4.41e-30: 132: 12.10
+	Hs
		616900 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		PTPRB_HUMAN (463-930): 1.38e-23: 111: 16.63
+	Hs
		647596 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		PTPRO_HUMAN (46-453): 1.96e-21: 103: 14.92
+	Hs
		616902 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		PTPRB_HUMAN (463-930): 1.38e-23: 111: 16.63
+	Hs
		441180 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		PTPRC_HUMAN (47-298): 3.49e-10: 67: 9.89
+	Hs
		441182 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		PTPRC_HUMAN (47-298): 3.49e-10: 67: 9.89
+	Hs
		441200 MK14_HUMAN (36-377): 1.51e-111: 332: 49.13		PTPRC_HUMAN (47-298): 3.49e-10: 67: 9.89