HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UBE2S (Q16763)
Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)
Gene: UBE2S

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.969

Property	Details
Experiments	25527291, 27425610, 30279270, 30097011, 31230944, 33082289, 37558718, 22069333, 17597759
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 222
+	Hs
		647684 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (11-157): 1.8e-84: 249: 37.42
+	Hs
		647533 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (11-157): 1.42e-83: 246: 36.74
+	Hs
		647506 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (11-157): 3.81e-83: 245: 35.37
+	Hs
		647521 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (11-157): 3.05e-82: 243: 35.37
+	Hs
		647508 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (1-157): 4.15e-76: 229: 31.85
+	Hs
		647619 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (2-157): 1.06e-75: 229: 32.05
+	Hs
		647626 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (2-157): 1.13e-75: 228: 31.41
+	Hs
		647502 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (8-154): 4.95e-72: 217: 34.01
+	Hs
		647524 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2N_HUMAN (12-159): 4.95e-72: 217: 37.16
+	Hs
		647537 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (14-153): 1.49e-30: 112: 36.43
+	Dm
		762720 Q8T0L3_DROME (36-1057): 0: 1108: 59.75		UBE2N_DROME (11-156): 3.23e-72: 217: 37.67
+	Sp
		314596 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (11-156): 1.44e-81: 241: 36.30
+	Sc
		585681 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (11-156): 1.29e-80: 239: 37.67
+	Hs
		48358 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UBE2S_HUMAN (1-222): 3.29e-86: 256: 100.00
+	Hs
		48351 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (11-157): 1.42e-83: 246: 36.74
+	Hs
		48347 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (11-157): 3.81e-83: 245: 35.37
+	Hs
		48349 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (11-157): 3.05e-82: 243: 35.37
+	Hs
		833587 UBA7_HUMAN (41-1057): 0: 1006: 46.00		UB2E1_HUMAN (1-157): 4.15e-76: 229: 31.85
+	Sp
		150903 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC13_SCHPO (8-153): 7.24e-35: 122: 43.84
+	Sc
		649511 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC13_YEAST (7-156): 2.56e-33: 119: 42.67