HitPredict

Interactor 1: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Interactor 2: UBC13 (P52490)
Ubiquitin-conjugating enzyme E2 13 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 13) (Ubiquitin carrier protein 13) (Ubiquitin-protein ligase 13)
Gene: UBC13

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	11805837
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1024 Sc			1 153
+	Hs
		647684 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D4_HUMAN (4-149): 5.43e-81: 236: 48.63
+	Hs
		647506 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D1_HUMAN (4-149): 6.62e-80: 234: 47.95
+	Hs
		647533 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D2_HUMAN (4-149): 7.47e-80: 234: 47.95
+	Hs
		647521 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D3_HUMAN (4-149): 7.55e-79: 231: 47.26
+	Hs
		647619 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E3_HUMAN (1-149): 1.46e-74: 223: 46.98
+	Hs
		647626 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E2_HUMAN (1-149): 8.02e-75: 223: 46.98
+	Hs
		647508 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E1_HUMAN (1-149): 5.55e-73: 218: 46.31
+	Hs
		647524 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBE2N_HUMAN (1-151): 1.15e-70: 211: 68.87
+	Hs
		647502 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBE2A_HUMAN (1-146): 1.76e-69: 208: 34.01
+	Sc
		585681 UBA1_YEAST (1-1024): 0: 1092: 100.00		UBC4_YEAST (1-148): 5.44e-80: 234: 49.32
+	Hs
		647570 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UE2NL_HUMAN (1-148): 1.44e-61: 188: 65.77
+	Sp
		314596 UBA1_SCHPO (1-1024): 0: 1045: 58.19		UBC4_SCHPO (4-148): 9.19e-79: 231: 48.28
+	Sp
		150903 UBA1_SCHPO (1-1024): 0: 1045: 58.19		UBC13_SCHPO (3-148): 2.41e-72: 215: 70.55
+	Dm
		762720 Q8T0L3_DROME (2-1024): 0: 1020: 49.08		UBE2N_DROME (1-151): 3.89e-71: 212: 69.54
+	Hs
		48347 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D1_HUMAN (4-149): 6.62e-80: 234: 47.95
+	Hs
		48351 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D2_HUMAN (4-149): 7.47e-80: 234: 47.95
+	Hs
		48349 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D3_HUMAN (4-149): 7.55e-79: 231: 47.26
+	Hs
		833587 UBA7_HUMAN (5-1024): 0: 913: 37.09		UB2E1_HUMAN (1-149): 5.55e-73: 218: 46.31
+	Hs
		1381215 SAE2_HUMAN (24-440): 1.02e-74: 261: 16.14		UB2E3_HUMAN (1-149): 1.46e-74: 223: 46.98
+	Hs
		982256 UBA3_HUMAN (790-994): 6.5e-41: 159: 14.55		UB2D2_HUMAN (4-149): 7.47e-80: 234: 47.95