HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.711

Property	Details
Experiments	12135708, 11782427, 14982882, unassigned3799, 10704825
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 676
+	Mm
		1022233 SHC1_MOUSE (1-583): 1.06e-180: 524: 94.51		GAB2_MOUSE (3-676): 1.72e-174: 515: 90.95
+	Mm
		1022216 SHC1_MOUSE (1-583): 1.06e-180: 524: 94.51		Q3ZB59_MOUSE (3-676): 2.79e-174: 514: 91.10
+	Hs
		711340 SHC1_HUMAN (1-583): 0: 529: 100.00		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Mm
		1022230 SHC1_MOUSE (1-583): 1.06e-180: 524: 94.51		GAB1_MOUSE (3-675): 1.11e-141: 431: 37.73
+	Hs
		1106495 SHC3_HUMAN (6-582): 8.25e-126: 384: 45.81		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		594144 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Hs
		699899 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Mm
		686964 P85A_MOUSE (300-581): 1.94e-37: 149: 15.99		Q3ZB59_MOUSE (3-676): 2.79e-174: 514: 91.10
+	Hs
		584536 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		1106514 VAV3_HUMAN (163-579): 1.3e-43: 168: 13.50		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		222077 NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		473414 HCK_HUMAN (348-575): 6.63e-42: 160: 17.16		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		593987 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		294858 BCAR3_HUMAN (379-583): 6.26e-38: 151: 23.83		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		699736 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		456105 FES_HUMAN (326-581): 1.81e-37: 150: 21.79		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Dm
		1463284 Q9V3C8_DROME (128-581): 5.67e-82: 264: 36.56		DOS_DROME (8-494): 2.46e-54: 202: 18.90
+	Hs
		1235000 GULP1_HUMAN (137-420): 5.87e-48: 171: 20.00		PKHA7_HUMAN (6-454): 6.89e-45: 174: 13.48
+	Hs
		222143 NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83		SESQ1_HUMAN (6-115): 6.96e-26: 108: 27.27
+	Hs
		215903 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		SYNJ1_HUMAN (219-635): 5.66e-13: 74.8: 11.91