Protein: SPTCS
Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein)

Gene: SPTCS, SPG11
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q96JI7

Gene Ontology (top 5):
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1395024

AP5M1
AP-5 complex subunit mu-1

3

0

High-throughput

0.638

High

835362

VIPR2
Vasoactive intestinal polypeptide receptor 2

3

0

High-throughput

0.634

High

1395047

CRYL1
Lambda-crystallin homolog

2

0

High-throughput

0.602

High

638500

FPR1
fMet-Leu-Phe receptor

2

3

High-throughput

0.601

High

1101632

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

2

High-throughput

0.601

High

1049665

1433F
14-3-3 protein eta

2

5

Small-scale

0.586

High

1394965

VCIP1
Deubiquitinating protein VCPIP1

2

0

Small-scale

0.580

High

1050708

DYN1
Dynamin-1

2

0

Small-scale

0.566

High

1395018

DNJC7
DnaJ homolog subfamily C member 7

2

0

Small-scale

0.551

High

182729

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

956979

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

1316698

ABI1
Abl interactor 1

1

1

High-throughput

0.536

High

1395034

ABI2
Abl interactor 2

1

2

High-throughput

0.536

High

212883

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.513

High

347252

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

359858

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

884470

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

High-throughput

0.513

High

1180656

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.513

High

1205769

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

1357196

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

1383810

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1390204

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.513

High

1395021

BBS2
BBSome complex member BBS2

1

0

High-throughput

0.513

High

1395023

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1395033

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

1395036

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

1395041

SNX6
Sorting nexin-6

1

0

High-throughput

0.513

High

1395046

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

1395048

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.513

High

1395049

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

1395050

NPTN
Neuroplastin

1

0

High-throughput

0.513

High

1395051

WASF2
Actin-binding protein WASF2

1

0

High-throughput

0.513

High

691337

1433T
14-3-3 protein theta

1

5

Small-scale

0.501

High

730147

1433B
14-3-3 protein beta/alpha

1

5

Small-scale

0.501

High

966748

1433G
14-3-3 protein gamma

1

5

Small-scale

0.501

High

990607

1433Z
14-3-3 protein zeta/delta

1

5

Small-scale

0.501

High

1177065

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

971882

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.480

High

461817

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468692

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

901491

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

902007

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

223255

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

315890

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

372855

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

562317

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.458

High

1233419

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1338322

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

238825

KALRN
Kalirin

1

2

Small-scale

0.457

High

269596

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

Small-scale

0.457

High

335166

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

Small-scale

0.457

High

391652

FRIH
Ferritin heavy chain

1

1

Small-scale

0.457

High

930017

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

Small-scale

0.457

High

1028845

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

Small-scale

0.457

High

1092476

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

Small-scale

0.457

High

1117443

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

Small-scale

0.457

High

1140190

ARHG6
Rho guanine nucleotide exchange factor 6

1

1

Small-scale

0.457

High

1295386

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

1

2

Small-scale

0.457

High

1389345

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

Small-scale

0.457

High

669354

ACKR3
Atypical chemokine receptor 3

1

3

High-throughput

0.445

High

67496

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

Small-scale

0.438

High

161303

ENC1
Ectoderm-neural cortex protein 1

1

0

Small-scale

0.438

High

273701

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

0

Small-scale

0.438

High

287993

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

Small-scale

0.438

High

358778

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.438

High

397999

FA11
Coagulation factor XI

1

0

Small-scale

0.438

High

402659

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.438

High

408135

TBB4A
Tubulin beta-4A chain

1

0

Small-scale

0.438

High

446457

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.438

High

451238

NFL
Neurofilament light polypeptide

1

0

Small-scale

0.438

High

533736

CLUS
Clusterin

1

0

Small-scale

0.438

High

561142

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

Small-scale

0.438

High

586986

CHIN
N-chimaerin

1

0

Small-scale

0.438

High

628007

ANXA7
Annexin A7

1

0

Small-scale

0.438

High

714943

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.438

High

828241

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

Small-scale

0.438

High

839170

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

0

Small-scale

0.438

High

840121

CASP2
Caspase-2

1

0

Small-scale

0.438

High

1088971

TP53B
TP53-binding protein 1

1

0

Small-scale

0.438

High

1098095

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.438

High

1101470

KCAB2
Voltage-gated potassium channel subunit beta-2

1

0

Small-scale

0.438

High

1123761

DCTN1
Dynactin subunit 1

1

0

Small-scale

0.438

High

1129363

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

Small-scale

0.438

High

1136838

MO4L2
Mortality factor 4-like protein 2

1

0

Small-scale

0.438

High

1142731

PDK2
[Pyruvate dehydrogenase

1

0

Small-scale

0.438

High

1159139

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

0

Small-scale

0.438

High

1208192

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

1

0

Small-scale

0.438

High

1212833

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

Small-scale

0.438

High

1233134

RGPA1
Ral GTPase-activating protein subunit alpha-1

1

0

Small-scale

0.438

High

1315944

CHSS2
Chondroitin sulfate synthase 2

1

0

Small-scale

0.438

High

1347318

TTC8
Tetratricopeptide repeat protein 8

1

0

Small-scale

0.438

High

1383436

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

Small-scale

0.438

High

1385132

MOAP1
Modulator of apoptosis 1

1

0

Small-scale

0.438

High

1395020

CSN4
COP9 signalosome complex subunit 4

1

0

Small-scale

0.438

High

1395025

GO45
Golgin-45

1

0

Small-scale

0.438

High

1395026

HIPK2
Homeodomain-interacting protein kinase 2

1

0

Small-scale

0.438

High

1395027

GOLP3
Golgi phosphoprotein 3

1

0

Small-scale

0.438

High

1395028

E41L1
Band 4.1-like protein 1

1

0

Small-scale

0.438

High

1395029

SYCM
Probable cysteine--tRNA ligase, mitochondrial

1

0

Small-scale

0.438

High

1395030

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

Small-scale

0.438

High

1395032

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

0

Small-scale

0.438

High

1395035

ATX10
Ataxin-10

1

0

Small-scale

0.438

High

1395039

FBX9
F-box only protein 9

1

0

Small-scale

0.438

High

1395042

EXOC7
Exocyst complex component 7

1

0

Small-scale

0.438

High

1395044

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

Small-scale

0.438

High

1395045

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.438

High

1310629

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

2

High-throughput

0.437

High

139292

UPK2
Uroplakin-2

1

0

High-throughput

0.426

High

231616

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

635907

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

704059

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.426

High

1010966

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.426

High

1395017

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.426

High

1395040

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

318045

TOM70
Mitochondrial import receptor subunit TOM70

1

1

Small-scale

0.417

High

1286980

DAAM2
Disheveled-associated activator of morphogenesis 2

1

1

Small-scale

0.417

High

1253645

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

1395016

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.318

High

1395038

SRTD3
SERTA domain-containing protein 3

1

0

High-throughput

0.299

High

280948

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

296733

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

1208947

DCA10
DDB1- and CUL4-associated factor 10

1

0

High-throughput

0.279

Low

1325823

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1359072

SPRY4
SPRY domain-containing protein 4

1

0

High-throughput

0.279

Low

1388936

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

1395019

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

275085

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

Small-scale

0.238

Low

286331

ZN821
Zinc finger protein 821

1

0

Small-scale

0.238

Low

1093690

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

0

Small-scale

0.238

Low

1127554

SPRL1
SPARC-like protein 1

1

0

Small-scale

0.238

Low

1131888

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

Small-scale

0.238

Low

1215546

FRY
Protein furry homolog

1

0

Small-scale

0.238

Low

1271391

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

Small-scale

0.238

Low

1325272

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

Small-scale

0.238

Low

1329372

EID2
EP300-interacting inhibitor of differentiation 2

1

0

Small-scale

0.238

Low

1379991

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

Small-scale

0.238

Low

1395015

EP400
E1A-binding protein p400

1

0

Small-scale

0.238

Low

1395022

KDM5D
Lysine-specific demethylase 5D

1

0

Small-scale

0.238

Low

1395031

ZHANG
CREB/ATF bZIP transcription factor

1

0

Small-scale

0.238

Low

1395037

IF172
Intraflagellar transport protein 172 homolog

1

0

Small-scale

0.238

Low

1395043

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

Small-scale

0.238

Low

50663

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

1219532

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1395014

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025