Protein: NKG2A
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)

Gene: NKG2A, KLRC1
Organism: Homo sapiens
Interactions: 167
UniProt ID: P26715

Gene Ontology (top 5):
GO:0001915 - negative regulation of T cell mediated cytotoxicity
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002250 - adaptive immune response
GO:0002305 - CD8-positive, gamma-delta intraepithelial T cell differentiation
GO:0002769 - natural killer cell inhibitory signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

644565

KLRD1
Natural killer cells antigen CD94

7

18

Small-scale

0.960

High

644622

KLRG1
Killer cell lectin-like receptor subfamily G member 1

2

16

High-throughput

0.783

High

644632

CLC7A
C-type lectin domain family 7 member A

2

17

High-throughput

0.783

High

644653

CLC2D
C-type lectin domain family 2 member D

2

17

High-throughput

0.783

High

644557

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

20

Small-scale

0.754

High

253937

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

20

High-throughput

0.691

High

644535

NKG2C
NKG2-C type II integral membrane protein

1

17

High-throughput

0.691

High

644550

EPHB4
Ephrin type-B receptor 4

1

10

High-throughput

0.691

High

644553

FCGRN
IgG receptor FcRn large subunit p51

1

20

High-throughput

0.691

High

644559

IDD
Integral membrane protein DGCR2/IDD

1

8

High-throughput

0.691

High

644566

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

20

High-throughput

0.691

High

644614

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

7

High-throughput

0.691

High

644616

HMR1
Major histocompatibility complex class I-related gene protein

1

20

High-throughput

0.691

High

644626

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

16

High-throughput

0.691

High

644631

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

8

High-throughput

0.691

High

644633

CNTP3
Contactin-associated protein-like 3

1

14

High-throughput

0.691

High

644647

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

20

High-throughput

0.691

High

644649

MRC2
C-type mannose receptor 2

1

18

High-throughput

0.691

High

644659

JAG2
Protein jagged-2

1

9

High-throughput

0.691

High

644560

PMP22
Peripheral myelin protein 22

3

7

High-throughput

0.675

High

644590

POTEE
POTE ankyrin domain family member E

1

4

High-throughput

0.618

High

644597

AMGO1
Amphoterin-induced protein 1

1

20

High-throughput

0.618

High

533124

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

20

Small-scale

0.618

High

596868

MAL
Myelin and lymphocyte protein

3

8

High-throughput

0.616

High

267324

CLD11
Claudin-11

2

6

High-throughput

0.606

High

306759

VAMP5
Vesicle-associated membrane protein 5

2

4

High-throughput

0.606

High

644536

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

6

High-throughput

0.606

High

644537

CD82
CD82 antigen

2

13

High-throughput

0.606

High

644540

CXB2
Gap junction beta-2 protein

2

4

High-throughput

0.606

High

644545

CD151
CD151 antigen

2

15

High-throughput

0.606

High

644551

EMP1
Epithelial membrane protein 1

2

6

High-throughput

0.606

High

644552

EMP3
Epithelial membrane protein 3

2

6

High-throughput

0.606

High

644555

MYPR
Myelin proteolipid protein

2

1

High-throughput

0.606

High

644564

MALL
MAL-like protein

2

8

High-throughput

0.606

High

644576

NKG7
Protein NKG7

2

2

High-throughput

0.606

High

644579

TTMP
TPA-induced transmembrane protein

2

1

High-throughput

0.606

High

644581

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

1

High-throughput

0.606

High

644583

TSPO2
Translocator protein 2

2

3

High-throughput

0.606

High

644627

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

2

6

High-throughput

0.606

High

644634

GPR61
G-protein coupled receptor 61

2

4

High-throughput

0.606

High

644644

CXB4
Gap junction beta-4 protein

2

4

High-throughput

0.606

High

644591

TM182
Transmembrane protein 182

2

0

High-throughput

0.580

High

644636

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.580

High

354302

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

20

High-throughput

0.575

High

570305

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

20

Small-scale

0.575

High

49446

CLRN2
Clarin-2

2

2

High-throughput

0.553

High

276304

UPK1B
Uroplakin-1b

2

14

High-throughput

0.553

High

305360

ZFPL1
Zinc finger protein-like 1

2

2

High-throughput

0.553

High

312995

BMP10
Bone morphogenetic protein 10

2

1

High-throughput

0.553

High

314580

CXB6
Gap junction beta-6 protein

2

4

High-throughput

0.553

High

644578

CTXN3
Cortexin-3

2

2

High-throughput

0.553

High

644589

BRID5
BRICHOS domain-containing protein 5

2

2

High-throughput

0.553

High

644592

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

1

High-throughput

0.553

High

644593

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

5

High-throughput

0.553

High

644601

LSME2
Leucine-rich single-pass membrane protein 2

2

1

High-throughput

0.553

High

644617

TMM54
Transmembrane protein 54

2

1

High-throughput

0.553

High

644628

CGRF1
Cell growth regulator with RING finger domain protein 1

2

1

High-throughput

0.553

High

644651

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

4

High-throughput

0.553

High

165162

PLXB2
Plexin-B2

1

20

High-throughput

0.536

High

233053

FZD6
Frizzled-6

1

4

High-throughput

0.536

High

234781

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

5

High-throughput

0.536

High

253452

PLXA2
Plexin-A2

1

20

High-throughput

0.536

High

314812

LARG1
Xylosyl- and glucuronyltransferase LARGE1

1

8

High-throughput

0.536

High

320760

SEM4F
Semaphorin-4F

1

11

High-throughput

0.536

High

530837

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

11

High-throughput

0.536

High

546648

B4GT1
Beta-1,4-galactosyltransferase 1

1

4

High-throughput

0.536

High

574499

ITB5
Integrin beta-5

1

10

High-throughput

0.536

High

644539

CALX
Calnexin

1

20

High-throughput

0.536

High

644544

GLRB
Glycine receptor subunit beta

1

3

High-throughput

0.536

High

644546

MA2A2
Alpha-mannosidase 2x

1

4

High-throughput

0.536

High

644547

DYN2
Dynamin-2

1

4

High-throughput

0.536

High

644548

PLXA3
Plexin-A3

1

17

High-throughput

0.536

High

644554

BACE1
Beta-secretase 1

1

5

High-throughput

0.536

High

644556

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

644562

TGBR3
Transforming growth factor beta receptor type 3

1

1

High-throughput

0.536

High

644563

HYAL2
Hyaluronidase-2

1

2

High-throughput

0.536

High

644568

MTR1L
Melatonin-related receptor

1

6

High-throughput

0.536

High

644569

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

6

High-throughput

0.536

High

644570

GAS6
Growth arrest-specific protein 6

1

15

High-throughput

0.536

High

644572

RB39A
Ras-related protein Rab-39A

1

9

High-throughput

0.536

High

644575

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.536

High

644594

LRP10
Low-density lipoprotein receptor-related protein 10

1

11

High-throughput

0.536

High

644595

GALT7
N-acetylgalactosaminyltransferase 7

1

14

High-throughput

0.536

High

644598

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

14

High-throughput

0.536

High

644602

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

1

High-throughput

0.536

High

644606

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

1

14

High-throughput

0.536

High

644608

SPP2B
Signal peptide peptidase-like 2B

1

2

High-throughput

0.536

High

644613

BT2A2
Butyrophilin subfamily 2 member A2

1

1

High-throughput

0.536

High

644615

SEM4D
Semaphorin-4D

1

11

High-throughput

0.536

High

644618

SO4A1
Solute carrier organic anion transporter family member 4A1

1

4

High-throughput

0.536

High

644619

OTUL
Ubiquitin thioesterase otulin

1

1

High-throughput

0.536

High

644620

RB39B
Ras-related protein Rab-39B

1

9

High-throughput

0.536

High

644624

S47A1
Multidrug and toxin extrusion protein 1

1

4

High-throughput

0.536

High

644625

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.536

High

644637

SEM6A
Semaphorin-6A

1

14

High-throughput

0.536

High

644640

RN167
E3 ubiquitin-protein ligase RNF167

1

8

High-throughput

0.536

High

644641

VEZA
Vezatin

1

2

High-throughput

0.536

High

644642

PGAP6
Post-GPI attachment to proteins factor 6

1

1

High-throughput

0.536

High

644643

ABCB6
ATP-binding cassette sub-family B member 6

1

8

High-throughput

0.536

High

644655

PLXA1
Plexin-A1

1

17

High-throughput

0.536

High

644656

GRID1
Glutamate receptor ionotropic, delta-1

1

1

High-throughput

0.536

High

644658

DYN3
Dynamin-3

1

6

High-throughput

0.536

High

644664

LRP12
Low-density lipoprotein receptor-related protein 12

1

12

High-throughput

0.536

High

644665

BACE2
Beta-secretase 2

1

5

High-throughput

0.536

High

644538

CALR
Calreticulin

1

20

High-throughput

0.515

High

644662

ITM2B
Integral membrane protein 2B

1

10

High-throughput

0.515

High

644596

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

0

High-throughput

0.513

High

644600

WDFY3
WD repeat and FYVE domain-containing protein 3

1

0

High-throughput

0.513

High

644607

NLGN2
Neuroligin-2

1

0

High-throughput

0.513

High

644648

ATX10
Ataxin-10

1

0

High-throughput

0.513

High

644574

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

161019

CLGN
Calmegin

1

20

High-throughput

0.489

High

206896

CHSTA
Carbohydrate sulfotransferase 10

1

5

High-throughput

0.489

High

213257

SNG3
Synaptogyrin-3

1

1

High-throughput

0.489

High

238842

TPST2
Protein-tyrosine sulfotransferase 2

1

2

High-throughput

0.489

High

253773

XYLK
Glycosaminoglycan xylosylkinase

1

2

High-throughput

0.489

High

280144

C1QRF
C1q-related factor

1

7

High-throughput

0.489

High

301179

RHBT3
Rho-related BTB domain-containing protein 3

1

11

High-throughput

0.489

High

314541

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

9

High-throughput

0.489

High

321331

STR3N
STARD3 N-terminal-like protein

1

4

High-throughput

0.489

High

331217

CHK2
Serine/threonine-protein kinase Chk2

1

3

High-throughput

0.489

High

580168

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

1

High-throughput

0.489

High

644542

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

6

High-throughput

0.489

High

644549

AP3M2
AP-3 complex subunit mu-2

1

3

High-throughput

0.489

High

644558

TBA1B
Tubulin alpha-1B chain

1

6

High-throughput

0.489

High

644561

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

1

2

High-throughput

0.489

High

644567

TBB3
Tubulin beta-3 chain

1

7

High-throughput

0.489

High

644571

STAR3
StAR-related lipid transfer protein 3

1

4

High-throughput

0.489

High

644573

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

8

High-throughput

0.489

High

644577

TBB8
Tubulin beta-8 chain

1

7

High-throughput

0.489

High

644580

PIGG
GPI ethanolamine phosphate transferase 2

1

6

High-throughput

0.489

High

644582

DIK1A
Divergent protein kinase domain 1A

1

5

High-throughput

0.489

High

644584

TBC9B
TBC1 domain family member 9B

1

2

High-throughput

0.489

High

644585

HEAT6
HEAT repeat-containing protein 6

1

3

High-throughput

0.489

High

644587

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

High-throughput

0.489

High

644599

CDK20
Cyclin-dependent kinase 20

1

1

High-throughput

0.489

High

644603

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

7

High-throughput

0.489

High

644605

NETO2
Neuropilin and tolloid-like protein 2

1

8

High-throughput

0.489

High

644609

SFXN5
Sideroflexin-5

1

5

High-throughput

0.489

High

644611

PXYP1
2-phosphoxylose phosphatase 1

1

4

High-throughput

0.489

High

644612

CHPT1
Cholinephosphotransferase 1

1

2

High-throughput

0.489

High

644623

C1GLC
C1GALT1-specific chaperone 1

1

7

High-throughput

0.489

High

644629

CDC6
Cell division control protein 6 homolog

1

1

High-throughput

0.489

High

644630

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

14

High-throughput

0.489

High

644635

TM39B
Transmembrane protein 39B

1

2

High-throughput

0.489

High

644639

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

4

High-throughput

0.489

High

644645

MDN1
Midasin

1

5

High-throughput

0.489

High

644646

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

12

High-throughput

0.489

High

644650

B4GT7
Beta-1,4-galactosyltransferase 7

1

4

High-throughput

0.489

High

644652

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

1

High-throughput

0.489

High

644654

EI2BD
Translation initiation factor eIF2B subunit delta

1

4

High-throughput

0.489

High

644657

DD19B
ATP-dependent RNA helicase DDX19B

1

4

High-throughput

0.489

High

644660

CDYL
Chromodomain Y-like protein

1

2

High-throughput

0.489

High

644661

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

1

9

High-throughput

0.489

High

644663

AP3M1
AP-3 complex subunit mu-1

1

3

High-throughput

0.489

High

644541

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

644543

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.470

High

644610

NEK7
Serine/threonine-protein kinase Nek7

1

5

High-throughput

0.470

High

92714

TM262
Cation channel sperm-associated auxiliary subunit TMEM262

2

0

High-throughput

0.316

High

514344

PSPC
Surfactant protein C

2

0

High-throughput

0.316

High

644604

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

2

0

High-throughput

0.316

High

63290

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.279

Low

644586

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

0

High-throughput

0.279

Low

644588

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.279

Low

644621

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.279

Low

644638

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

High-throughput

0.279

Low

320089

CXL14
C-X-C motif chemokine 14

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024