Protein: PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)

Gene: PLCD1
Organism: Homo sapiens
Interactions: 59
UniProt ID: P51178

Gene Ontology (top 5):
GO:0001786 - phosphatidylserine binding
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0005509 - calcium ion binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

902379

RB11B
Ras-related protein Rab-11B

2

6

High-throughput

0.789

High

902395

RB39B
Ras-related protein Rab-39B

1

5

High-throughput

0.691

High

902401

SRMS
Tyrosine-protein kinase Srms

1

17

High-throughput

0.691

High

902409

JAM1
Junctional adhesion molecule A

1

12

High-throughput

0.691

High

539785

RALA
Ras-related protein Ral-A

1

20

Small-scale

0.680

High

902388

GPBP1
Vasculin

2

1

High-throughput

0.628

High

902392

IL31R
Interleukin-31 receptor subunit alpha

2

2

High-throughput

0.628

High

373844

RASN
GTPase NRas

1

20

High-throughput

0.618

High

374480

RASH
GTPase HRas

1

19

High-throughput

0.618

High

375304

RASK
GTPase KRas

1

20

High-throughput

0.618

High

902400

RBM24
RNA-binding protein 24

3

1

High-throughput

0.609

High

845228

GDF5
Growth/differentiation factor 5

2

0

High-throughput

0.602

High

642533

TGM2
Protein-glutamine gamma-glutamyltransferase 2

2

2

Small-scale

0.595

High

169479

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.580

High

902403

SCN3B
Sodium channel regulatory subunit beta-3

1

2

High-throughput

0.575

High

902406

FBXL4
F-box/LRR-repeat protein 4

2

2

High-throughput

0.574

High

902376

IMB1
Importin subunit beta-1

1

1

Small-scale

0.561

High

902402

ANLN
Anillin

1

1

High-throughput

0.553

High

902394

US6NL
USP6 N-terminal-like protein

1

1

High-throughput

0.536

High

902399

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

1

High-throughput

0.536

High

902410

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

902378

PLEC
Plectin

1

2

High-throughput

0.515

High

301799

ANXA9
Annexin A9

1

0

High-throughput

0.513

High

866617

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

902375

ITAD
Integrin alpha-D

1

0

High-throughput

0.513

High

902387

DYM
Dymeclin

1

0

High-throughput

0.513

High

902405

FBX3
F-box only protein 3

1

0

High-throughput

0.513

High

902408

KIF3A
Kinesin-like protein KIF3A

1

0

High-throughput

0.513

High

421746

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

326683

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.489

High

370602

FOS
Protein c-Fos

1

2

High-throughput

0.489

High

902407

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.489

High

330770

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

872087

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

902377

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

902385

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

607292

NEUM
Neuromodulin

1

0

Small-scale

0.458

High

529373

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

902386

PAXI1
PAX-interacting protein 1

1

3

High-throughput

0.439

High

105597

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

261135

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

902384

OLFM4
Olfactomedin-4

1

0

High-throughput

0.426

High

902398

ZBT18
Zinc finger and BTB domain-containing protein 18

1

2

High-throughput

0.407

High

902381

TEX35
Testis-expressed protein 35

3

0

High-throughput

0.347

High

902383

IFIX
Pyrin and HIN domain-containing protein 1

3

0

High-throughput

0.347

High

902396

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

3

0

High-throughput

0.347

High

902397

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

49394

DHR12
Dehydrogenase/reductase SDR family member 12

1

0

High-throughput

0.279

Low

429127

7B2
Neuroendocrine protein 7B2

1

0

High-throughput

0.279

Low

755469

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

876297

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

902382

TMTC4
Protein O-mannosyl-transferase TMTC4

1

0

High-throughput

0.279

Low

902389

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

902390

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.279

Low

902391

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.279

Low

902393

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

902404

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

528431

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.232

Low

902380

TMM31
Transmembrane protein 31

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025