Protein: TGM2
Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)

Gene: TGM2
Organism: Homo sapiens
Interactions: 159
UniProt ID: P21980

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0003810 - protein-glutamine gamma-glutamyltransferase activity
GO:0005509 - calcium ion binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

389026

FINC
Fibronectin

7

2

Small-scale

0.749

High

642507

TGM2
Protein-glutamine gamma-glutamyltransferase 2

2

3

Small-scale

0.744

High

642511

IKBA
NF-kappa-B inhibitor alpha

2

2

Small-scale

0.737

High

563192

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.650

High

421503

A4
Amyloid-beta precursor protein

3

0

Small-scale

0.636

High

177171

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

1

High-throughput

0.621

High

431708

ITB1
Integrin beta-1

2

3

Small-scale

0.595

High

642533

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

2

2

Small-scale

0.595

High

536493

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.586

High

384112

CO1A1
Collagen alpha-1(I) chain

2

4

Small-scale

0.585

High

642548

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

1

High-throughput

0.584

High

642581

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

Small-scale

0.578

High

642508

CBL
E3 ubiquitin-protein ligase CBL

1

1

Small-scale

0.561

High

642542

TF65
Transcription factor p65

2

0

Small-scale

0.559

High

642547

SQSTM
Sequestosome-1

2

0

Small-scale

0.559

High

642582

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

642521

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.541

High

642513

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

Small-scale

0.537

High

642526

PAXI
Paxillin

1

0

Small-scale

0.537

High

464418

TSP1
Thrombospondin-1

1

1

Small-scale

0.536

High

212753

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

1

High-throughput

0.536

High

213808

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

251857

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

1

High-throughput

0.536

High

294774

CAN15
Calpain-15

1

3

High-throughput

0.536

High

438026

CO5A2

1

4

High-throughput

0.536

High

473662

ITA5
Integrin alpha-5

1

2

High-throughput

0.536

High

507077

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.536

High

635443

CO5A1

1

4

High-throughput

0.536

High

642530

RBM25
RNA-binding protein 25

1

1

High-throughput

0.536

High

642534

BLK
Tyrosine-protein kinase Blk

1

2

High-throughput

0.536

High

642586

WNK1
Serine/threonine-protein kinase WNK1

1

1

High-throughput

0.536

High

642599

MCM8
DNA helicase MCM8

1

4

High-throughput

0.536

High

642593

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.518

High

555869

CADH1
Cadherin-1

1

1

Small-scale

0.515

High

135490

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.515

High

245866

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.515

High

336278

SOX14
Transcription factor SOX-14

1

1

High-throughput

0.515

High

415348

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.515

High

642532

DYN2
Dynamin-2

1

3

High-throughput

0.515

High

642543

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.515

High

642570

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

642550

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.513

High

642551

MVP
Major vault protein

1

0

High-throughput

0.513

High

642552

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.513

High

642554

SF3B4
Splicing factor 3B subunit 4

1

0

High-throughput

0.513

High

642556

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

642557

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

642560

TIGD5
Tigger transposable element-derived protein 5

1

0

High-throughput

0.513

High

642562

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

0

High-throughput

0.513

High

642563

DEN4C
DENN domain-containing protein 4C

1

0

High-throughput

0.513

High

642566

BORA
Protein aurora borealis

1

0

High-throughput

0.513

High

642577

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.513

High

642585

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

642590

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

642591

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.513

High

642595

E2AK4
eIF-2-alpha kinase GCN2

1

0

High-throughput

0.513

High

642598

ENOPH
Enolase-phosphatase E1

1

0

High-throughput

0.513

High

481090

HMGB1
High mobility group protein B1

1

3

Small-scale

0.508

High

642540

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.508

High

642546

PAK1
Serine/threonine-protein kinase PAK 1

1

1

High-throughput

0.508

High

642555

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.508

High

384303

CO4A1

1

4

Small-scale

0.501

High

447979

ITAV
Integrin alpha-V

1

2

Small-scale

0.501

High

551730

COBA1

1

4

Small-scale

0.501

High

551760

CO6A1

1

3

Small-scale

0.501

High

642514

LYOX
Protein-lysine 6-oxidase

1

3

Small-scale

0.501

High

642520

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

4

Small-scale

0.501

High

642536

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.493

High

160682

TOR1A
Torsin-1A

1

0

High-throughput

0.493

High

301340

WFS1
Wolframin

1

0

High-throughput

0.493

High

389792

TTHY
Transthyretin

1

0

High-throughput

0.493

High

642516

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.493

High

642522

HD
Huntingtin

1

0

High-throughput

0.493

High

642538

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

642549

SEPT6
Septin-6

1

0

High-throughput

0.493

High

642561

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.493

High

642574

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

642559

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.489

High

642568

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

2

High-throughput

0.489

High

642576

GT251
Procollagen galactosyltransferase 1

1

1

High-throughput

0.489

High

642544

AKP13
A-kinase anchor protein 13

1

0

Small-scale

0.484

High

369617

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.481

High

369833

CO3
Complement C3

1

1

High-throughput

0.481

High

625194

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.481

High

642517

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

642535

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

3

High-throughput

0.481

High

642580

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

2

High-throughput

0.481

High

642509

LAMA1
Laminin subunit alpha-1

1

0

Small-scale

0.480

High

642531

MMP14
Matrix metalloproteinase-14

1

0

Small-scale

0.480

High

642553

PCOC1
Procollagen C-endopeptidase enhancer 1

1

0

Small-scale

0.480

High

240747

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

317986

TOM70
Mitochondrial import receptor subunit TOM70

1

2

Small-scale

0.479

High

371161

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

400280

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

413184

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

424773

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.479

High

479766

GSTP1
Glutathione S-transferase P

1

1

Small-scale

0.479

High

507524

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.479

High

534628

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

552128

ADT3
ADP/ATP translocase 3

1

2

Small-scale

0.479

High

557092

SRC
Proto-oncogene tyrosine-protein kinase Src

1

2

Small-scale

0.479

High

590800

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

592617

ITB4
Integrin beta-4

1

3

Small-scale

0.479

High

642512

ITA3
Integrin alpha-3

1

2

Small-scale

0.479

High

642518

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

642519

HSPA9
Stress-70 protein, mitochondrial

1

6

Small-scale

0.479

High

642523

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.479

High

642524

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

642529

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

642567

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

642583

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

642588

ANLN
Anillin

1

1

High-throughput

0.479

High

642596

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

642600

LOXL2
Lysyl oxidase homolog 2

1

4

High-throughput

0.479

High

109366

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

642592

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

2

High-throughput

0.470

High

642579

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.464

High

337994

ABCA1
Phospholipid-transporting ATPase ABCA1

1

0

High-throughput

0.460

High

366152

HPT
Haptoglobin

1

0

High-throughput

0.460

High

617199

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.460

High

642515

GRN
Progranulin

1

0

High-throughput

0.460

High

642525

GLR
Glucagon receptor

1

0

High-throughput

0.460

High

642528

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.460

High

642537

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

0

High-throughput

0.460

High

642539

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.460

High

642545

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

0

High-throughput

0.460

High

642587

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

0

Small-scale

0.460

High

642597

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

642601

CERT
Ceramide transfer protein

1

0

High-throughput

0.460

High

142486

IMA3
Importin subunit alpha-3

1

0

Small-scale

0.458

High

217828

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

247675

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

352962

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

442589

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

471620

CY1
Cytochrome c1, heme protein, mitochondrial

1

0

Small-scale

0.458

High

475520

K1C19
Keratin, type I cytoskeletal 19

1

0

Small-scale

0.458

High

572741

PA2GA
Phospholipase A2, membrane associated

1

0

Small-scale

0.458

High

603832

CXA1
Gap junction alpha-1 protein

1

0

Small-scale

0.458

High

629561

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

636040

CD11B
Cyclin-dependent kinase 11B

1

0

High-throughput

0.458

High

642510

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

Small-scale

0.458

High

642527

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

642541

VIGLN
Vigilin

1

0

High-throughput

0.458

High

642558

H31T
Histone H3.1t

1

0

Small-scale

0.458

High

642573

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

Small-scale

0.458

High

642575

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

642589

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

642565

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

2

High-throughput

0.445

High

642569

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

584703

NDKA
Nucleoside diphosphate kinase A

1

0

Small-scale

0.426

High

642564

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.279

Low

47305

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

642571

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

642584

LACRT
Extracellular glycoprotein lacritin

1

0

Small-scale

0.261

Low

642578

T176A
Transmembrane protein 176A

1

0

High-throughput

0.251

Low

642594

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.251

Low

105336

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

642572

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025