Protein: ZBTB5
Zinc finger and BTB domain-containing protein 5

Gene: ZBTB5
Organism: Homo sapiens
Interactions: 54
UniProt ID: O15062

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176377

ZBT7B
Zinc finger and BTB domain-containing protein 7B

3

20

High-throughput

0.871

High

176406

BCOR
BCL-6 corepressor

1

14

Small-scale

0.740

High

176404

KLH40
Kelch-like protein 40

2

18

High-throughput

0.726

High

51754

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

19

High-throughput

0.691

High

176379

DCX
Neuronal migration protein doublecortin

4

2

High-throughput

0.643

High

176407

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.618

High

176382

BAG4
BAG family molecular chaperone regulator 4

2

2

High-throughput

0.606

High

176381

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

20

Small-scale

0.590

High

176422

METL5
rRNA N(6)-adenosine-methyltransferase METTL5

2

0

High-throughput

0.580

High

176424

FXL17
F-box/LRR-repeat protein 17

1

15

High-throughput

0.575

High

176399

CDC16
Cell division cycle protein 16 homolog

2

3

High-throughput

0.574

High

176420

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

11

High-throughput

0.574

High

176380

NCOR1
Nuclear receptor corepressor 1

1

20

Small-scale

0.573

High

176427

NCOR2
Nuclear receptor corepressor 2

1

16

Small-scale

0.573

High

176425

SWP70
Switch-associated protein 70

1

7

High-throughput

0.573

High

176383

HERC2
E3 ubiquitin-protein ligase HERC2

2

5

High-throughput

0.571

High

176385

P53
Cellular tumor antigen p53

1

14

Small-scale

0.561

High

176386

SP1
Transcription factor Sp1

1

19

Small-scale

0.561

High

176395

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.561

High

176405

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

12

High-throughput

0.558

High

176389

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.541

High

176403

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

176411

RSPH1
Radial spoke head 1 homolog

1

8

High-throughput

0.541

High

176421

JADE2
E3 ubiquitin-protein ligase Jade-2

1

9

High-throughput

0.541

High

176384

S100B
Protein S100-B

1

8

High-throughput

0.536

High

176390

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

176409

ZN784
Zinc finger protein 784

1

20

High-throughput

0.536

High

176415

TRI52
E3 ubiquitin-protein ligase TRIM52

1

20

High-throughput

0.536

High

176426

RCOR1
REST corepressor 1

1

18

High-throughput

0.536

High

176392

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

2

High-throughput

0.494

High

176393

SEC13
Protein SEC13 homolog

1

2

High-throughput

0.489

High

176408

DCLK2
Serine/threonine-protein kinase DCLK2

1

10

High-throughput

0.489

High

176418

KIFC3
Kinesin-like protein KIFC3

1

8

High-throughput

0.489

High

142715

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

176378

HDAC3
Histone deacetylase 3

1

17

Small-scale

0.479

High

176387

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

176388

PML
Protein PML

1

20

High-throughput

0.479

High

176391

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

176394

TF65
Transcription factor p65

1

13

High-throughput

0.479

High

176397

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

176398

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

18

High-throughput

0.479

High

176400

HDAC1
Histone deacetylase 1

1

19

Small-scale

0.479

High

176401

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

18

High-throughput

0.479

High

176402

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

176412

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

176413

KAT2B
Histone acetyltransferase KAT2B

1

14

Small-scale

0.479

High

176414

KAT5
Histone acetyltransferase KAT5

1

7

Small-scale

0.479

High

176417

SIN3A
Paired amphipathic helix protein Sin3a

1

4

Small-scale

0.479

High

176419

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

176423

ZMYM2
Zinc finger MYM-type protein 2

1

16

High-throughput

0.479

High

176416

SNX27
Sorting nexin-27

1

9

High-throughput

0.437

High

71044

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

12

High-throughput

0.407

High

176410

NPRL2
GATOR1 complex protein NPRL2

2

0

High-throughput

0.328

High

176396

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025