Protein: RN183
E3 ubiquitin-protein ligase RNF183 (EC 2.3.2.27)

Gene: RN183, RNF183
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q96D59

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005765 - lysosomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1387099

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

0

High-throughput

0.646

High

1379863

FATE1
Fetal and adult testis-expressed transcript protein

3

0

High-throughput

0.639

High

957643

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

0

High-throughput

0.580

High

1060201

B2CL1
Bcl-2-like protein 1

1

1

Small-scale

0.578

High

1387095

RN183
E3 ubiquitin-protein ligase RNF183

2

0

Small-scale

0.577

High

1033131

EWS
RNA-binding protein EWS

1

0

High-throughput

0.518

High

833500

PTGDS
Prostaglandin-H2 D-isomerase

1

0

High-throughput

0.513

High

522122

BCL2
Apoptosis regulator Bcl-2

1

1

Small-scale

0.501

High

216776

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

242541

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.493

High

246084

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

301619

WFS1
Wolframin

1

0

High-throughput

0.493

High

479611

DOPO
Dopamine beta-hydroxylase

1

0

High-throughput

0.493

High

791622

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

843847

HD
Huntingtin

1

0

High-throughput

0.493

High

1025134

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.493

High

1096153

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

1098365

ERCC8
DNA excision repair protein ERCC-8

1

0

High-throughput

0.493

High

1369606

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1387097

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

High-throughput

0.493

High

1387101

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

1383916

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

1

High-throughput

0.481

High

422841

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1199348

GLE1
mRNA export factor GLE1

1

1

High-throughput

0.470

High

1387096

Q96FI0
Ubiquitin-conjugating enzyme E2 W

1

1

High-throughput

0.470

High

163344

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

0

Small-scale

0.458

High

175153

SC16A
Protein transport protein Sec16A

1

0

Small-scale

0.458

High

167522

TX1B3
Tax1-binding protein 3

1

0

High-throughput

0.299

High

482524

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.282

High

1068850

IFFO1
Non-homologous end joining factor IFFO1

1

0

High-throughput

0.282

High

1387098

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.282

High

977790

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.279

Low

1209985

TM201
Transmembrane protein 201

1

0

High-throughput

0.279

Low

47390

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

163581

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.268

Low

369726

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.268

Low

389868

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

415775

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.268

Low

458928

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

622237

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

703249

HXD10
Homeobox protein Hox-D10

1

0

High-throughput

0.268

Low

713124

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.268

Low

767297

MERL
Merlin

1

0

High-throughput

0.268

Low

833336

PERI
Peripherin

1

0

High-throughput

0.268

Low

896852

DYN2
Dynamin-2

1

0

High-throughput

0.268

Low

905014

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.268

Low

927475

ATX1
Ataxin-1

1

0

High-throughput

0.268

Low

954572

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.268

Low

1031938

NC2B
Protein Dr1

1

0

High-throughput

0.268

Low

1123751

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.268

Low

1159355

FRDA
Frataxin, mitochondrial

1

0

High-throughput

0.268

Low

1279684

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.268

Low

1292920

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1387100

Q9P1N4
PRO1359

1

0

High-throughput

0.268

Low

1387102

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.268

Low

683498

IKBA
NF-kappa-B inhibitor alpha

1

0

Small-scale

0.249

Low

1053718

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025