Protein: TMLH
Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (Epsilon-trimethyllysine hydroxylase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD)

Gene: TMLH, TMLHE
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q9NVH6

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0045329 - carnitine biosynthetic process
GO:0050353 - trimethyllysine dioxygenase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1450535

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

2

Small-scale

0.647

High

533006

CH60
60 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.571

High

1162587

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

Small-scale

0.559

High

276181

NIPS2
Protein NipSnap homolog 2

1

2

High-throughput

0.536

High

690564

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

1397668

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

1412220

NPS3B
Protein NipSnap homolog 3B

1

2

High-throughput

0.536

High

1450540

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

275401

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

289821

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

772420

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

High-throughput

0.513

High

834266

PLPL4
Patatin-like phospholipase domain-containing protein 4

1

0

High-throughput

0.513

High

842247

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

869254

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

1100648

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.513

High

1238415

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1240348

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.513

High

1242641

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1312900

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

1389217

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

1414063

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

1414166

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1418022

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

0

High-throughput

0.513

High

1419414

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.513

High

1450539

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1450541

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1450542

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

1450544

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

1450545

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1450547

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

471279

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

1403449

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1218332

SDHF4
Succinate dehydrogenase assembly factor 4, mitochondrial

1

0

High-throughput

0.458

High

1450440

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

191404

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.426

High

273109

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.426

High

725665

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

0

High-throughput

0.426

High

1108201

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

1123450

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.426

High

1450538

STIM2
Stromal interaction molecule 2

2

0

High-throughput

0.328

High

156354

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.279

Low

259136

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.279

Low

1022117

SHC2
SHC-transforming protein 2

1

0

High-throughput

0.279

Low

1349131

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1356094

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.279

Low

1384949

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

1387794

ARHGQ
Rho guanine nucleotide exchange factor 26

1

0

High-throughput

0.279

Low

1402413

RSLAB
Ras-like protein family member 10B

1

0

High-throughput

0.279

Low

1411064

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.279

Low

1450543

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.279

Low

1450546

KLK5
Kallikrein-5

1

0

High-throughput

0.279

Low

1450548

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1123541

BTG3
Protein BTG3

1

0

High-throughput

0.269

Low

125636

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

132333

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

Small-scale

0.249

Low

279516

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

885904

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.249

Low

992541

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.249

Low

1114429

CUL3
Cullin-3

1

0

High-throughput

0.249

Low

1178417

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1255772

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

430418

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

1065682

RBL2
Retinoblastoma-like protein 2

1

0

Small-scale

0.232

Low

1413634

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.232

Low

1450536

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.232

Low

1450537

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025