Protein: GLSK
Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]

Gene: GLSK, GLS
Organism: Homo sapiens
Interactions: 199
UniProt ID: O94925

Gene Ontology (top 5):
GO:0001967 - suckling behavior
GO:0002087 - regulation of respiratory gaseous exchange by nervous system process
GO:0004359 - glutaminase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

322340

GLSL
Glutaminase liver isoform, mitochondrial

2

18

High-throughput

0.789

High

322222

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

322201

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.691

High

322277

CUL5
Cullin-5

1

17

High-throughput

0.691

High

322185

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.665

High

322333

KLH13
Kelch-like protein 13

1

4

High-throughput

0.665

High

322206

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

1

High-throughput

0.656

High

322176

GLSK
Glutaminase kidney isoform, mitochondrial

1

18

Small-scale

0.647

High

322327

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

3

2

Small-scale

0.640

High

322269

RM43
Large ribosomal subunit protein mL43

3

0

High-throughput

0.638

High

322301

TR61B
tRNA

3

0

High-throughput

0.638

High

322252

MRM1
rRNA methyltransferase 1, mitochondrial

3

0

High-throughput

0.628

High

322332

COKA1

1

6

High-throughput

0.618

High

322219

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.618

High

322223

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

322224

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.618

High

322225

RHOG
Rho-related GTP-binding protein RhoG

1

18

High-throughput

0.618

High

322260

TBA1A
Tubulin alpha-1A chain

1

10

High-throughput

0.618

High

322262

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

322263

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.618

High

322274

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

4

High-throughput

0.618

High

322283

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

2

High-throughput

0.618

High

322322

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.618

High

322181

OTC
Ornithine transcarbamylase, mitochondrial

2

2

High-throughput

0.611

High

322183

TNFA
Tumor necrosis factor

3

2

High-throughput

0.609

High

275216

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

322221

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

322317

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

0

High-throughput

0.585

High

240346

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

279598

CISY
Citrate synthase, mitochondrial

2

5

High-throughput

0.584

High

322179

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

5

High-throughput

0.584

High

322186

GCR
Glucocorticoid receptor

2

19

Small-scale

0.584

High

322233

GRSF1
G-rich sequence factor 1

2

6

High-throughput

0.584

High

322271

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.578

High

322220

TERA
Transitional endoplasmic reticulum ATPase

1

10

High-throughput

0.575

High

322275

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.574

High

322344

CFA45
Cilia- and flagella-associated protein 45

2

4

High-throughput

0.567

High

322193

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

322248

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

322267

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.559

High

322338

NUFP1
FMR1-interacting protein NUFIP1

2

1

High-throughput

0.558

High

322259

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

322313

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

322254

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.546

High

322276

RSPH1
Radial spoke head 1 homolog

1

3

High-throughput

0.541

High

322184

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.536

High

322191

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.536

High

322199

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

322203

KAD4
Adenylate kinase 4, mitochondrial

1

2

High-throughput

0.536

High

322211

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

High-throughput

0.536

High

322226

SHC2
SHC-transforming protein 2

1

18

High-throughput

0.536

High

322247

TAZ
Tafazzin

1

1

High-throughput

0.536

High

322296

NPS3B
Protein NipSnap homolog 3B

1

1

High-throughput

0.536

High

322335

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

322341

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

104999

APRIO
Alternative prion protein

2

4

High-throughput

0.533

High

322182

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.533

High

322345

MTUS1
Microtubule-associated tumor suppressor 1

1

7

High-throughput

0.515

High

322202

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.513

High

322216

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

322253

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

322258

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

322286

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

322287

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

322307

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

322339

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

322350

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

322351

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

0

High-throughput

0.513

High

322354

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

185309

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.501

High

224455

PI15
Peptidase inhibitor 15

1

1

High-throughput

0.489

High

322196

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

High-throughput

0.489

High

322245

NAB2
NGFI-A-binding protein 2

1

2

High-throughput

0.489

High

322266

CDR2L
Cerebellar degeneration-related protein 2-like

1

1

High-throughput

0.489

High

322331

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

2

High-throughput

0.489

High

322348

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.489

High

322235

SNTA1
Alpha-1-syntrophin

1

11

Small-scale

0.481

High

61383

VWA8
von Willebrand factor A domain-containing protein 8

1

6

High-throughput

0.479

High

136757

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

12

High-throughput

0.479

High

216595

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

281844

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

287215

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

296175

SCO1
Protein SCO1 homolog, mitochondrial

1

5

High-throughput

0.479

High

322177

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

322178

BAG3
BAG family molecular chaperone regulator 3

1

3

Small-scale

0.479

High

322180

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

322187

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

322192

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

322200

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

Small-scale

0.479

High

322207

LONM
Lon protease homolog, mitochondrial

1

8

High-throughput

0.479

High

322208

HSPA9
Stress-70 protein, mitochondrial

1

16

High-throughput

0.479

High

322209

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

322215

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

322217

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

322218

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

322227

TFAM
Transcription factor A, mitochondrial

1

6

High-throughput

0.479

High

322231

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

322232

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

322234

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

322236

BIRC3
Baculoviral IAP repeat-containing protein 3

1

8

High-throughput

0.479

High

322237

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

322243

ELOB
Elongin-B

1

1

High-throughput

0.479

High

322246

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

322250

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

322255

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

2

High-throughput

0.479

High

322264

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

322265

ATCAY
Caytaxin

1

1

Small-scale

0.479

High

322270

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

322272

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

322278

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

322279

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

322280

MCUR1
Mitochondrial calcium uniporter regulator 1

1

2

High-throughput

0.479

High

322282

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.479

High

322285

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

322288

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

9

High-throughput

0.479

High

322290

IMP1L
Mitochondrial inner membrane protease subunit 1

1

2

High-throughput

0.479

High

322292

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

322294

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.479

High

322295

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

High-throughput

0.479

High

322305

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

8

High-throughput

0.479

High

322306

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

2

High-throughput

0.479

High

322311

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

322312

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

322314

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

322318

SFXN1
Sideroflexin-1

1

4

High-throughput

0.479

High

322319

NGRN
Neugrin

1

1

High-throughput

0.479

High

322320

ANLN
Anillin

1

2

High-throughput

0.479

High

322323

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

322324

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

322328

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

322329

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

322336

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

322337

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

322346

FZR1
Fizzy-related protein homolog

1

3

Small-scale

0.479

High

322347

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.479

High

322257

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.470

High

322334

ATX10
Ataxin-10

1

0

Small-scale

0.460

High

66105

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

134508

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

183563

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

274954

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

322189

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

322190

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

322195

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

322210

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

322214

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

322229

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

322230

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

322238

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

322239

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

322242

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

322244

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

322249

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

322251

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

322256

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

322261

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

322268

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.458

High

322273

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.458

High

322281

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

322284

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

322289

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

322291

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

322297

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

322298

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

322299

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

322300

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

322302

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

322303

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.458

High

322304

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

322309

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

322310

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

322316

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

322325

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

322326

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

322330

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

322352

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

322353

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

72919

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.445

High

248817

GSDME
Gasdermin-E

1

1

High-throughput

0.445

High

322194

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

322241

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

Small-scale

0.445

High

322293

CK5P2
CDK5 regulatory subunit-associated protein 2

1

14

High-throughput

0.445

High

322188

NFIC
Nuclear factor 1 C-type

1

10

High-throughput

0.437

High

322198

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.437

High

322204

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

322213

MAGA6
Melanoma-associated antigen 6

1

7

High-throughput

0.437

High

322315

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.437

High

322342

XPO7
Exportin-7

1

10

High-throughput

0.437

High

322343

HDAC9
Histone deacetylase 9

1

6

Small-scale

0.437

High

322228

TAGL
Transgelin

1

7

High-throughput

0.407

High

322349

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.407

High

142194

CCL22
C-C motif chemokine 22

2

0

High-throughput

0.328

High

322212

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

322308

TSN10
Tetraspanin-10

1

0

High-throughput

0.279

Low

322321

KISHB
Protein kish-B

1

0

High-throughput

0.279

Low

322197

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

322205

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

322240

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025