Protein: ERRFI
ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)

Gene: ERRFI, ERRFI1
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9UJM3

Gene Ontology (top 5):
GO:0001889 - liver development
GO:0001894 - tissue homeostasis
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363997

EGFR
Epidermal growth factor receptor

16

13

Small-scale

0.764

High

988012

GRB2
Growth factor receptor-bound protein 2

12

20

Small-scale

0.761

High

955735

CDC42
Cell division control protein 42 homolog

1

13

Small-scale

0.724

High

972107

1433E
14-3-3 protein epsilon

5

3

High-throughput

0.716

High

990846

1433Z
14-3-3 protein zeta/delta

4

20

Small-scale

0.694

High

411106

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

9

High-throughput

0.672

High

440775

FYN
Tyrosine-protein kinase Fyn

3

13

High-throughput

0.665

High

1102291

ATM
Serine-protein kinase ATM

2

1

Small-scale

0.614

High

691522

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

966995

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

1049889

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

1445938

RAB18
Ras-related protein Rab-18

1

0

Small-scale

0.589

High

861831

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

Small-scale

0.578

High

730337

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.576

High

719044

WEE1
Wee1-like protein kinase

1

8

Small-scale

0.561

High

1460608

STX8
Syntaxin-8

1

2

Small-scale

0.552

High

170411

AURKA
Aurora kinase A

1

3

High-throughput

0.541

High

294898

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

20

High-throughput

0.541

High

336799

BAG4
BAG family molecular chaperone regulator 4

1

1

High-throughput

0.541

High

641277

FGFR2
Fibroblast growth factor receptor 2

1

10

High-throughput

0.541

High

648720

FGFR4
Fibroblast growth factor receptor 4

1

13

High-throughput

0.541

High

1352008

RBCC1
RB1-inducible coiled-coil protein 1

1

10

High-throughput

0.541

High

619130

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

High-throughput

0.536

High

711427

SHC1
SHC-transforming protein 1

1

15

High-throughput

0.536

High

877467

MASP1
Mannan-binding lectin serine protease 1

1

1

High-throughput

0.536

High

882211

TCPG
T-complex protein 1 subunit gamma

1

7

High-throughput

0.536

High

1022118

SHC2
SHC-transforming protein 2

1

20

High-throughput

0.536

High

1201090

ACTBL
Beta-actin-like protein 2

1

11

High-throughput

0.536

High

1259558

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.536

High

1353544

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

14

High-throughput

0.536

High

1435420

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

730946

1433S
14-3-3 protein sigma

1

20

High-throughput

0.534

High

186229

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.518

High

1132462

CASP8
Caspase-8

1

0

High-throughput

0.518

High

1294966

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.518

High

484239

PGFRB
Platelet-derived growth factor receptor beta

1

9

Small-scale

0.515

High

1460607

ALK
ALK tyrosine kinase receptor

1

15

Small-scale

0.515

High

456885

ANXA2
Annexin A2

1

0

High-throughput

0.513

High

1398957

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.513

High

1400403

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

728471

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.506

High

557513

SRC
Proto-oncogene tyrosine-protein kinase Src

1

13

Small-scale

0.501

High

64960

ARRD5
Arrestin domain-containing protein 5

1

1

Small-scale

0.481

High

165430

PSA7
Proteasome subunit alpha type-7

1

2

Small-scale

0.481

High

701090

PSB6
Proteasome subunit beta type-6

1

3

Small-scale

0.481

High

986801

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

Small-scale

0.481

High

1086458

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

4

Small-scale

0.481

High

1236371

MFSD5
Molybdate-anion transporter

1

1

Small-scale

0.481

High

1332268

TAC2N
Tandem C2 domains nuclear protein

1

1

Small-scale

0.481

High

1369911

OSTF1
Osteoclast-stimulating factor 1

1

18

Small-scale

0.481

High

1370445

CSN5
COP9 signalosome complex subunit 5

1

2

Small-scale

0.481

High

1405035

NEUR1
Sialidase-1

1

1

Small-scale

0.481

High

1417277

TMM59
Transmembrane protein 59

1

1

Small-scale

0.481

High

1428704

SKI8
Superkiller complex protein 8

1

3

Small-scale

0.481

High

1437916

PKHA3
Pleckstrin homology domain-containing family A member 3

1

1

Small-scale

0.481

High

63058

POTEF
POTE ankyrin domain family member F

1

11

High-throughput

0.479

High

173521

XPO1
Exportin-1

1

1

High-throughput

0.479

High

343287

ERR2
Steroid hormone receptor ERR2

1

14

High-throughput

0.479

High

362400

ABL1
Tyrosine-protein kinase ABL1

1

14

Small-scale

0.479

High

538079

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

570629

GFAP
Glial fibrillary acidic protein

1

7

High-throughput

0.479

High

591879

H2AX
Histone H2AX

1

6

Small-scale

0.479

High

711953

LTK
Leukocyte tyrosine kinase receptor

1

16

Small-scale

0.479

High

720356

UFO
Tyrosine-protein kinase receptor UFO

1

10

Small-scale

0.479

High

953169

ACTB
Actin, cytoplasmic 1

1

11

High-throughput

0.479

High

977856

ACTA
Actin, aortic smooth muscle

1

10

High-throughput

0.479

High

987261

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

6

High-throughput

0.479

High

993374

ACTG
Actin, cytoplasmic 2

1

11

High-throughput

0.479

High

993447

ACTH
Actin, gamma-enteric smooth muscle

1

10

High-throughput

0.479

High

995881

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.479

High

996557

ACTS
Actin, alpha skeletal muscle

1

8

High-throughput

0.479

High

996890

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.479

High

1220876

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.479

High

1247535

POTEE
POTE ankyrin domain family member E

1

11

High-throughput

0.479

High

1410631

TBA1C
Tubulin alpha-1C chain

1

4

High-throughput

0.479

High

1460606

ERRFI
ERBB receptor feedback inhibitor 1

1

8

High-throughput

0.479

High

133386

DCTN6
Dynactin subunit 6

1

0

Small-scale

0.460

High

211515

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

0

Small-scale

0.460

High

425861

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

Small-scale

0.460

High

551326

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.460

High

664941

CRHBP
Corticotropin-releasing factor-binding protein

1

0

Small-scale

0.460

High

728692

IL2RG
Cytokine receptor common subunit gamma

1

0

Small-scale

0.460

High

932561

GAS1
Growth arrest-specific protein 1

1

0

Small-scale

0.460

High

963979

NPC2
NPC intracellular cholesterol transporter 2

1

0

Small-scale

0.460

High

1054536

AOXA
Aldehyde oxidase

1

0

Small-scale

0.460

High

1118831

TF2H2
General transcription factor IIH subunit 2

1

0

Small-scale

0.460

High

1157163

PDCD2
Programmed cell death protein 2

1

0

Small-scale

0.460

High

1351562

GNPI2
Glucosamine-6-phosphate deaminase 2

1

0

Small-scale

0.460

High

1390467

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

1

0

Small-scale

0.460

High

1411487

TM2D3
TM2 domain-containing protein 3

1

0

Small-scale

0.460

High

1412205

ZPBP1
Zona pellucida-binding protein 1

1

0

Small-scale

0.460

High

1460609

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

Small-scale

0.460

High

457762

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

959087

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

163188

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.445

High

1419409

ACTBM
Putative beta-actin-like protein 3

1

11

High-throughput

0.445

High

1194538

HYDIN
Hydrocephalus-inducing protein homolog

1

10

Small-scale

0.439

High

1393301

SH3Y1
SH3 domain-containing YSC84-like protein 1

1

20

Small-scale

0.439

High

1258614

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High

1350159

S7A13
Solute carrier family 7 member 13

1

0

Small-scale

0.251

Low

1406761

TIMP4
Metalloproteinase inhibitor 4

1

0

Small-scale

0.251

Low

1432819

GCP60
Golgi resident protein GCP60

1

0

Small-scale

0.251

Low

1435537

PACER
Protein associated with UVRAG as autophagy enhancer

1

0

Small-scale

0.251

Low

1438521

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

Small-scale

0.251

Low

1448419

MMP26
Matrix metalloproteinase-26

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025